Visual function alterations in Alzheimer Disease: A case report

Piñero, David P.; Monllor, Begoña; Moncho, Vicenta; Sáiz, Dolores de Fez

doi:10.1016/j.jcjo.2015.09.009

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…It allows the clinician to detect incipient alterations in magno-, parvo-, and koniocellular pathways that cannot be detected in a conventional perimetric exam. To this date, this technology has been reported to detect impairment in the achromatic and RG and BY chromatic mechanisms in a case of essential tremor and in Alzheimer 11, 12…”

Section: Discussionmentioning

confidence: 99%

Multichannel perimetric alterations in systemic lupus erythematosus treated with hydroxychloroquine

Piñero

Monllor

Camps

et al. 2017

Journal of Optometry

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Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations.We report the first case of SLE in which visual alterations were evaluated with multichannel perimetry.Some achromatic and color vision alterations may be present in SLE, especially when treated with hydroxychloroquine. The sensitivity losses detected in the chromatic channels in the central zone of the visual field were consistent with the results of the FM 100 Hue color test. Likewise, the multichannel perimetry detected sensitivity losses in the parafoveal area for both chromatic channels, especially for the blue-yellow.

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Section: Discussionmentioning

confidence: 99%

Multichannel perimetric alterations in systemic lupus erythematosus treated with hydroxychloroquine

Piñero

Monllor

Camps

et al. 2017

Journal of Optometry

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“…Visual perception and abnormalities of the retina have been investigated to provide diagnostic clues in AD. AD pathology may manifest in visual field defects, changes in contrast sensitivity and visual acuity, and impaired color recognition [170–177]. RGC degeneration, Aβ deposition with local myeloid and astrocyte infiltration, hyperphosphorylated tau, and optic nerve axon loss have all been described in AD eyes [178–183].…”

Section: Alzheimer’s Diseasementioning

confidence: 99%

Myeloid cells in retinal and brain degeneration

et al. 2021

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Retinal inflammation underlies multiple prevalent ocular and neurological diseases. Similar inflammatory processes are observed in glaucomatous optic neuropathy, age-related macular degeneration, retinitis pigmentosa, posterior uveitis, Alzheimer's disease, and Parkinson's disease. In particular, human and animal studies have demonstrated the important role microglia/macrophages play in initiating and maintaining a pro-inflammatory environment in degenerative processes impacting vision. On the other hand, microglia have also been shown to have a protective role in multiple central nervous system diseases. Identifying the mechanisms underlying cell dysfunction and death is the first step towards developing novel therapeutics for these diseases impacting the central nervous system. In addition to reviewing recent key studies defining important mediators of retinal inflammation, with an emphasis on translational studies that bridge this research from bench to bedside, we also highlight a promising therapeutic class of medications, the glucagon-like peptide-1 receptor agonists. Finally, we propose areas where additional research is necessary to identify mechanisms that can be modulated to shift the balance from a neurotoxic to a neuroprotective retinal environment.

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The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer’s Disease: Critical Aspects to Unravel

et al. 2019

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Visual function alterations in Alzheimer Disease: A case report

Abstract: Fig. 1 -Retinographies (top) and macular scans obtained by optical coherence tomography (bottom) for both eyes.

Cited by 4 publications

References 12 publications

Multichannel perimetric alterations in systemic lupus erythematosus treated with hydroxychloroquine

Multichannel perimetric alterations in systemic lupus erythematosus treated with hydroxychloroquine

Myeloid cells in retinal and brain degeneration

The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer’s Disease: Critical Aspects to Unravel

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