Visual Fields in Young Children Treated with Vigabatrin

Agrawal, Shivi; Mayer, D. Luisa; Hansen, Ronald M.; Fulton, Anne B.

doi:10.1097/opx.0b013e3181a7b3fc

Cited by 21 publications

(9 citation statements)

References 16 publications

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“…Nonetheless, the ERG variability is similar to that reported across laboratories, and the pediatric visual field test was validated against Goldmann perimetry [30]. Among the 27 patients tested longitudinally, only four showed systematic worsening of any parameter; that parameter was scotopic b-wave sensitivity, log r (Fig.…”

Section: Discussionmentioning

confidence: 89%

“…Visual fields were normal in 28 and abnormal in 11 (28 %). During the course of the study, one of these patients became capable of performing conventional Goldmann manual kinetic perimetry and Humphrey automated static perimetry; the results confirmed the presence of visual field abnormality as detected with the pediatric test procedure [30].…”

Section: Subjectsmentioning

confidence: 79%

“…Pediatric visual field testing was done in 39 of the 114 patients [30,31]; results from 27 have been reported previously [30]. Visual fields were normal in 28 and abnormal in 11 (28 %).…”

Section: Subjectsmentioning

confidence: 99%

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Electroretinographic (ERG) responses in pediatric patients using vigabatrin

et al. 2012

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The antiepileptic drug vigabatrin is known to cause retinal and visual dysfunction, particularly visual field defects, in some patients. Electroretinography (ERG) is used in an attempt to identify adverse effects of vigabatrin (VGB) in patients who are not candidates for conventional perimetry. We report data from 114 pediatric patients taking VGB referred for clinical evaluation; median age at test was 22.9 (2.4 to 266.1) months, and median duration of VGB use was 9.7 (0.3 to 140.7) months. Twenty-seven of them were tested longitudinally (3 to 12 ERG tests). ERG responses to full-field stimuli were recorded in scotopic and photopic conditions, and results were compared to responses from healthy control subjects. We found that abnormalities of photoreceptor and post-receptor ERG responses are frequent in these young patients. The most frequently abnormal scotopic parameter was post-receptor sensitivity, log σ, derived from the b-wave stimulus-response function; the most frequently abnormal photopic parameter was the implicit time of the OFF response (d-wave) to a long (150 ms) flash. Abnormal 30-Hz flicker response amplitude, previously reported to be a predictor of visual field loss, occurred infrequently. For the group as a whole, none of the ERG parameters changed significantly with increasing duration of VGB use. Four of the 27 patients tested longitudinally showed systematic worsening of log σ with duration of VGB use. In a subset of patients who underwent perimetry (N = 39), there was no significant association of any ERG parameter with visual field defects. We cannot determine whether the ERG abnormalities we found were due solely to the effects of VGB. We caution against over-reliance on the ERG to monitor pediatric patients for VGB toxicity and recommend further development of a reliable test of peripheral vision to supplant ERG testing.

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Section: Discussionmentioning

confidence: 89%

Section: Subjectsmentioning

confidence: 79%

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Electroretinographic (ERG) responses in pediatric patients using vigabatrin

et al. 2012

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“…White Sphere Kinetic Perimetry has been done successfully in developmentally delayed children using a larger object (6 0 vs 1.7 0 for Goldman Kinetic Perimetry); 8/28 children or 29% were found to have visual field defects in this study (7 OBJECTIVES: To determine time to vigabatrin (VGB, Sabril; Lundbeck, Deerfield, IL) induced retinal damage in children with infantile spasms (IS) and to identify risk factors for VGB-induced retinal damage (VGB-RD). METHODS: Observational cohort study including 146 participants (68 female, 81 male) with IS, an age-specific epilepsy syndrome of early infancy, treated with VGB.…”

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confidence: 89%

Limiting Retinal Toxicity of Vigabatrin in Children with Infantile Spasms

Kotagal¹

2015

Epilepsy Curr

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“…Chez l'enfant à partir de 6 ans, il est possible de suivre l'évolution du champ visuel périphérique avec un appareillage adapté (Agrawal et al, 2009), (Moskowitz et al, 2012).…”

Section: En Pratique…unclassified

VII-2 : ELECTROPHYSIOLOGIE PEDIATRIQUE : EXEMPLES Deuxième partie

Rigaudière¹,

Delouvrier²,

Gargasson³

2014

Oeil Et Physiologie De La Vision

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Evaluation de l'acuité visuelle en période préverbale Méthode objective : recueil des PEV damier Principe de la méthode Avantages, inconvénients Autres méthodes Regard préférentiel Nystagmus optocinétique Comparaison des résultats des trois méthodes Suivi d'une amblyopie Définition Amblyopie fonctionnelle : intérêt des PEV Mettre en évidence et suivre une amblyopie chez un enfant d'âge préverbal Evaluer la nécessité de poursuivre l'occlusion en cas d'échec apparent Retentissement visuel d'un traitement médicamenteux Rétinopathie Neuropathies Atteintes visuelles et pathologie générale Conclusion

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Visual Fields in Young Children Treated with Vigabatrin

Abstract: WSKP is feasible in VGB patients, even in those with developmental delays. WSKP has the potential to detect visual field constriction associated with VGB use.

Cited by 21 publications

References 16 publications

Electroretinographic (ERG) responses in pediatric patients using vigabatrin

Electroretinographic (ERG) responses in pediatric patients using vigabatrin

Limiting Retinal Toxicity of Vigabatrin in Children with Infantile Spasms

VII-2 : ELECTROPHYSIOLOGIE PEDIATRIQUE : EXEMPLES Deuxième partie

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