Visual field results and optic disc morphology in patients treated with allogeneic stem-cell transplantation in childhood

Abstract

ABSTRACT.Purpose: This study aimed to describe the Rarebit (RB) visual field and optic nerve size ⁄ morphology in patients treated with allogeneic stem-cell transplantation (SCT) in childhood, and to determine the impact of ocular status and conditioning regimens such as total body irradiation (TBI), chemotherapy and ⁄ or immunosuppressive drugs on the RB visual field. Methods: Ocular fundi were evaluated in 79 patients. Digital analyses regarding optic disc area (DA), rim area (RA) and cup area (CA) were performed in 45 of 49 patients. RB visual field testing was performed in 53 of 79 patients. The mean hit rate (MHR) was compared to corneal status, cataract, diagnosis and pre and post-SCT treatment. Two groups of healthy children and young adults (RB = 51, disc analysis = 49) were used as controls. Results: The SCT patients, examined at a median age of 15.4 years, had a significantly lower MHR [median 91% (range 45-99) right eye and 91% (range 41-91) left eye] compared to controls [median 96% (range 78-100) right eye]. SCT patients treated surgically for cataract and with intraocular lenses (IOLs) had a significantly lower MHR compared to other SCT patients. The MHR was also significantly influenced by type of conditioning. Patients conditioned with chemotherapy other than busulfan had significantly better MHR compared to those who had received single-dose TBI. SCT patients had a significantly larger CA and smaller RA than the controls. Conclusion: Patients treated with SCT in childhood have a significantly lower MHR than controls when examined with RB. Also, patients surgically treated for cataract and with IOL implantation had a significantly lower MHR.

Cup‐to‐disc and arteriole‐to‐venule ratios in children aged 6–7 and 12–13 years

“…It is becoming increasingly common to capture digital images of the fundus during routine eye examinations providing practitioners with a permanent record of the patient’s optic nerve and retina at a particular point in time. There is a large amount of information in the literature regarding optic disc characteristics in children with ocular pathology 1–3 . In addition, clinical norms for retinal features, [e.g.…”

Visual evoked potentials after hematopoietic allogeneic stem cell transplantation in childhood

“…Forty-seven of these 79 patients underwent VEPs. Data on demographics, cataract development, dry eye complications, visual fields results, and optic nerve morphology among the patients in the cohort has previously been reported (Fahnehjelm et al, 2007, Fahnehjelm et al, 2008, Tornquist et al, 2011). Patients were at a greater risk of developing cataract if conditioned with single fractio TBI (s-TBI) or fractionated TBI (f-TBI) when compared to busulfan or other chemotherapeutic drugs (Fahnehjelm et al, 2007).…”

“…Patients were at a greater risk of developing cataract if conditioned with single fractio TBI (s-TBI) or fractionated TBI (f-TBI) when compared to busulfan or other chemotherapeutic drugs (Fahnehjelm et al, 2007). Poorer visual fields outcomes were found in patients who had undergone HSCT compared with normal controls (Tornquist et al, 2011) and long term results have been published (Tear Fahnehjelm et al, 2016). …”

Regression Modeling to Inform Cell Incorporation Into Therapies for Craniosynostosis

“…1, 2 Progenitor cell transplantation is already the standard practice in the treatment of certain hematopoietic diseases. 3 Clinical trials are underway to investigate other applications for progenitor/stem cell therapy in several fields spanning cardiology, 4–6 hepatology, 7–10 wound healing, 11–13 immunology, 14–16 transplantation, 17 neurology, 18–20 ophthalmology, 21, 22 autoimmune disorders, 23, 24 urology, 25, 26 orthopaedics, 27, 28 and craniofacial biology. 29, 30 The tissue sources of the multipotent stem cells and tissue specific progenitor cells used for these therapies include adipose, muscle, and bone marrow tissues.…”