Visual field improvement after endoscopic transsphenoidal surgery in patients with pituitary adenoma

Abstract

PurposeTo analyze and predict the possibility of visual field (VF) recovery after endoscopic transsphenoidal surgery (ETSS) in patients with pituitary adenoma, we investigated the factors affecting the improvement of the visual field defect (VFD) and built a nomogram predictive model based on these risk factors. We further investigated specific recovery regions of VF associated with the improvement of VFD.MethodsThe clinical data of patients who underwent ETSS for pituitary adenomas at a single center between the January 2021 and April 2022 were retrospectively analyzed. Univariate and multivariate analyses were used to determine the predictive factors affecting the improvement in the VF defect and specific recovery regions in patients with pituitary adenomas after ETSS.ResultsWe enrolled 28 patients (56 eyes) who were hospitalized at our institution. Four clinical features, including compression of the optic chiasm, preoperative mean defect (MD), diffuse defect, and duration of the visual symptom, were chosen from the least absolute shrinkage and selection operator regression analysis to establish the predictive nomogram. The nomogram’s area under the curve (AUC) was 0.912, indicating a good degree of differentiation. A calibration plot was used to evaluate the predictive model’s calibration, and a decision curve was used to evaluate its clinical application value. The VF defects were improved in the 270–300° range (270–300: RR = 361.00, 95% CI: 21.01–6,202.41).ConclusionWe developed a predictive nomogram model based on significant visual field improvement-associated factors after ETSS in patients with pituitary adenoma. Postoperative visual field improvement is likely to begin at 270–300° in the inferior temporal quadrant. This improvement would enable personalized counselling for individual patients by precisely predicting the visual field recovery after surgery.

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“…It is the endoscopic skull-base surgery that has been reported to be the best option for visual recovery [44]. Predicting visual acuity and visual field outcomes after removal of chiasmal-sellar tumors is still an important task [107,108,109,110].…”

Asuhan Keperawatan Perioperatif pada Adenoma Hipofisis dengan Pendekatan Teori Adaptasi Roy

“…Hemianopia bitemporal terjadi akibat adanya penekanan langsung pada kiasma optikum, dimana pada kiasma optikum terdapat serabut syaraf nasal yang menyilang pada masing-masing syaraf optik. Penekanan pada kiasma optikum tidak hanya dapat menekan serabut saraf optikus, namun juga dapat menekan serabut saraf yang tidak bersilangan (Danesh-Meyer et al, 2019;Ji et al, 2023).…”

“…Jurnal Keperawatan Silampari 6 (2) 1975-1982 nasal yang menyilang pada masing-masing syaraf optik (Danesh-Meyer. et al, 2019;Ji et al, 2023).…”