Visual field changes as an early indicator of glioblastoma multiforme progression: two cases of&amp;nbsp;functional vision changes before MRI detection

Xie, Kate; Liu, Catherine Y.; Hasso, Anton N.; Crow, Robert W.

doi:10.2147/opth.s79723

Cited by 4 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Loss of RD3 expression correlates with the progression of the pathogenesis in neuroblastoma and a poor survival prognosis [12,14]. Interestingly, rare cases of vision impairment were reported as an early indicator of tumor progression in GBM patients [23,24,25]. Applying a data mining approach, we extended these previous studies by screening and analyzing multi-cohort data sets with respect to RD3 expression.…”

Section: Discussionmentioning

confidence: 92%

Retinal degeneration protein 3 mutants are associated with cell-cycle arrest and apoptosis

Bräuer,

Hausmann,

Zimmermann

et al. 2024

Preprint

View full text Add to dashboard Cite

Retinal degeneration protein 3 (RD3) plays a crucial role in controlling guanylate cyclase activity in photoreceptor rod and cone cells, and mediates trafficking processes within photoreceptor cells. Loss of RD3 function correlates with severe forms of retinal dystrophy and the development of aggressive neuroblastoma cancer. In the present study, we analysed RD3 expression by applying a data-mining approach using public databases. In addition, we performed an RD3 transcript analysis on specimens of glioma tissues from patients. We found that RD3 is downregulated in glioblastoma compared to non-tumor tissues. Low expression of RD3 in gliomas was also associated with a poor prognosis of survival rate. Applying a multi-cohort receiver operating characteristic test, we verified significant changes in RD3 expression in glioblastomas, indicating a potential use of RD3 in glioblastoma diagnosis. The apparent influence of RD3 on cell viability or on cell cycle progression we examined by overexpressing RD3 in a cell culture system. Wild-type RD3 significantly decreased cell viability, which subsequently led to cell-cycle arrest at the G2/M phase and induced cell apoptosis. Conversely, single-point mutations in RD3 at the exposed protein surface involved in RD3 target interaction diminished the impact of RD3 wild type, thereby showing its specificity. Therefore, expression of wild type RD3 might prevent tumor progression by facilitating the death of cancer cells or arresting the cell cycle in a developing tumor. Our findings further suggest that RD3 is a potential prognostic factor in glioblastoma.

show abstract

Section: Discussionmentioning

confidence: 92%

Retinal degeneration protein 3 mutants are associated with cell-cycle arrest and apoptosis

Bräuer,

Hausmann,

Zimmermann

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Peripapillary RNFL thickness reflects neuronal axons, and would allow quantification of ganglion cell axonal loss [ 26 ]. Moreover, VF values estimates functional loss of the whole visual pathway, from retina to cortex [ 27 ]. VF maps show a correspondence with neuronal distribution of RNFL in the ON head, as Garway et al demonstrated [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls

et al. 2018

View full text Add to dashboard Cite

BackgroundTo assess the retinal sensitivity in obstructive sleep apnea hypopnea syndrome (OSAHS) patients evaluated with standard automated perimetry (SAP). And to correlate the functional SAP results with structural parameters obtained with optical coherence tomography (OCT).MethodsThis prospective, observational, case-control study consisted of 63 eyes of 63 OSAHS patients (mean age 51.7 ± 12.7 years, best corrected visual acuity ≥20/25, refractive error less than three spherical or two cylindrical diopters, and intraocular pressure < 21 mmHg) who were enrolled and compared with 38 eyes of 38 age-matched controls. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured by Stratus OCT and SAP sensitivities and indices were explored with Humphrey Field Analyzer perimeter. Correlations between functional and structural parameters were calculated, as well as the relationship between ophthalmologic and systemic indices in OSAHS patients.ResultsOSAHS patients showed a significant reduction of the sensitivity for superior visual field division (p = 0.034, t-student test). When dividing the OSAHS group in accordance with the severity of the disease, nasal peripapillary RNFL thickness was significantly lower in severe OSAHS than that in controls and mild-moderate cases (p = 0.031 and p = 0.016 respectively, Mann-Whitney U test). There were no differences between groups for SAP parameters.We found no correlation between structural and functional variables. The central visual field sensitivity of the SAP revealed a poor Pearson correlation with the apnea-hipopnea index (0.284, p = 0.024).ConclusionsRetinal sensitivity show minor differences between healthy subjects and OSAHS. Functional deterioration in OSAHS patients is not easy to demonstrate with visual field examination.

show abstract

“…Also, vision impairment is closely related to glioblastoma. The worsening visual defects are one of Ivyspring International Publisher the important indicator for the investigation of tumor progression in glioblastoma patients [13]. Therefore, due to the coupling and interdependence characteristic of DR complications, the early diagnosis and detection of retinopathy in the diabetic individuals is imperative for the prevention of vision loss in patients.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive multimodal imaging of Diabetic Retinopathy: A survey on treatment methods and Nanotheranostics

Sadasivam¹,

Gopinath²,

Shakya³

et al. 2021

Nanotheranostics

View full text Add to dashboard Cite

Diabetes Retinopathy (DR) is one of the most prominent microvascular complications of diabetes. It is one of the pre-eminent causes for vision impairment followed by blindness among the working-age population worldwide. The de facto cause for DR remains challenging, despite several efforts made to unveil the mechanism underlying the pathology of DR. There is quite less availability of the low cost pre-emptive theranostic imaging tools in terms of in-depth resolution, due to the multiple factors involved in the etiology of DR. This review work comprehensively explores the various reports and research works on all perspectives of diabetic retinopathy (DR), and its mechanism. It also discusses various advanced non-destructive imaging modalities, current, and future treatment approaches. Further, the application of various nanoparticle-based drug delivery strategies used for the treatment of DR are also discussed. In a nutshell, the present review work bolsters the pursuit of the development of an advanced non-invasive optical imaging modal with a nano-theranostic approach for the future diagnosis and treatment of DR and its associated ocular complications.

show abstract

Visual field changes as an early indicator of glioblastoma multiforme progression: two cases of functional vision changes before MRI detection

Cited by 4 publications

References 14 publications

Retinal degeneration protein 3 mutants are associated with cell-cycle arrest and apoptosis

Retinal degeneration protein 3 mutants are associated with cell-cycle arrest and apoptosis

Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls

Non-invasive multimodal imaging of Diabetic Retinopathy: A survey on treatment methods and Nanotheranostics

Contact Info

Product

Resources

About