Visual field and optic disc progression in patients with different types of optic disc damage

Nicolela, Marcelo T.; McCormick, Terry A.; Drance, Stephen M.; Ferrier, Suzanne; LeBlanc, Raymond P.; Chauhan, Balwantray C.

doi:10.1016/s0161-6420(03)00801-7

Cited by 68 publications

(41 citation statements)

References 21 publications

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“…Rates of functional and structural deterioration in glaucoma can be highly variable between patients, [1][2][3][4] however, it is important to detect rapid rates of change that potentially result in serious visual impairment, to enable appropriate intervention. Although standard automated perimetry (SAP) has been the most widely used method to assess glaucomatous progression, imaging of the ONH and RNFL also provides important measures by which anatomical changes associated with glaucoma can be measured.…”

Section: Introductionmentioning

confidence: 99%

Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects

O’Leary

Artes

Hutchison

et al. 2012

Eye

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Purpose To examine the rates of retinal nerve fibre layer thickness (RNFLT) change in glaucoma patients and healthy, age-similar control subjects with three techniques: scanning laser polarimetry with variable corneal compensation (VCC) and enhanced corneal compensation (ECC), and timedomain optical coherence tomography (OCT). Methods Sixty-one patients and thirty-three controls were examined with each technique and with standard automated perimetry (SAP) every 6 months. Rates of global RNFLT change and SAP mean deviation (MD) change were estimated with linear mixedeffects models. Results The median (interquartile range) baseline age was 64.4 (58.2, 71.0) years for patients and 62.4 (56.3, 70.1) years for controls (P ¼ 0.56). There was a median of seven examinations over 3.1 years for patients and six examinations in 3.0 years for controls. Baseline visual field MD and RNFLT for all imaging modalities were significantly lower (Po0.01) in patients compared with controls. Rates of RNFLT change were not significantly different between patients and controls (PZ0.19). Mean rates of VCC-measured RNFLT change were À 0.18 and À 0.37 lm per year in patients and controls, whereas the respective figures for ECC and OCT were À 0.13 and À 0.31 lm per year, and 0.04 and 0.61 lm per year. Mean rates of MD change were À 0.20 and 0.03 dB per year in patients and controls, respectively (P ¼ 0.01). Conclusion Rates of RNFLT change in glaucoma patients were not statistically different from control subjects for any modality. A significantly negative rate of MD change in patients suggests a genuine, continued deterioration in these patients not reflected by RNFLT changes.

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Section: Introductionmentioning

confidence: 99%

Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects

O’Leary

Artes

Hutchison

et al. 2012

Eye

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“…2 A complete assessment of rates of disease progression requires both structural and functional measures, as it is known that many patients seem to progress by one method and not the other. [3][4][5][6] Although functional outcomes have an unquestionable relevance to patients, it has been shown that structural changes can often precede functional losses and be an earlier marker of deterioration. More importantly, a recent study showed that structural changes observed on optic disc stereophotographs are predictive of future functional losses and, therefore, carry clinically relevant prognostic information.…”

Section: Introductionmentioning

confidence: 99%

Assessment of rates of structural change in glaucoma using imaging technologies

Mansouri

Leite

Medeiros

et al. 2011

Eye

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Purpose To review the ability of current imaging technologies to provide estimates of rates of structural change in glaucoma patients.Patients and methods Review of literature. Results Imaging technologies, such as confocal scanning laser ophthalmoscopy (CSLO), scanning laser polarimetry (SLP), and optical coherence tomography (OCT), provide quantifiable and reproducible measurements of the optic disc and parapapillary retinal nerve fibre layer (RNFL). Rates of change as quantified by the rim area (RA) (for CSLO) and RNFL thickness (for SLP and OCT) are related to glaucoma progression as detected by conventional methods (eg, visual fields and optic disc photography). Evidence shows that rates of RNFL and RA loss are significantly faster in progressing compared with nonprogressing glaucoma patients. Conclusion Measurements of rates of optic disc and RNFL change are becoming increasingly precise and individualized. Currently available imaging technologies have the ability to detect and quantify progression in glaucoma, and their measurements may be suitable end points in glaucoma clinical trials.

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“…The average age of this group was older than the other groups, and they have the best prognosis. 20 A lower diastolic velocity and a higher resistance index 39 were shown in patients with this type of disc. In addition, shallower maximum cup depth is associated with worse MD (r = 0.4809, P = 0.0396) in the patients with the SS type, and this parameter was significantly correlated with the MD in only the SS type.…”

Section: Dovepressmentioning

confidence: 76%

“…19 They found that patients with SS were less likely to have a progression of the optic disc morphology and visual field defects than patients with the other types of discs with similar IOPs. 20 The Heidelberg Retinal Tomograph-II (HRT-II) is a confocal scanning laser imaging instrument that measures the 3-dimensional topography of the optic nerve head. Different features of the optic disc morphology are calculated from the measurements and used to characterize the morphology of the optic disc.…”

Section: Dovepressmentioning

confidence: 99%

“…The optic discs were divided into four types following the classification of Nicolela and colleagues 19,20 ( Figure 1); focal ischemic (FI) disc type; myopic (MY) disc type; senile sclerotic (SS) disc type; and generalized enlargement (GE) disc type. The FI type of optic disc had a focal loss of nerve fibers on the neuronal rim and the other areas were normal.…”

Section: Classification Of Disc Appearancesmentioning

confidence: 99%

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Correlation between morphology of optic disc determined by Heidelberg Retina Tomograph II and visual function in eyes with open-angle glaucoma

Omodaka

Nakazawa²,

Otomo³

et al. 2010

OPTH

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Purpose:To investigate the correlation between the morphology of the optic disc and the visual function of eyes with open-angle glaucoma (OAG). Patients and Methods: One hundred and three eyes of 76 patients with OAG were studied. The baseline optic disc morphology was used to classify the eyes into four types: focal ischemic type (FI), myopic glaucomatous type (MY), senile sclerotic type (SS), and generalized enlargement type (GE). The morphological parameters of the disc were determined by the Heidelberg Retina Tomograph II (HRT-II) and the visual function by the mean deviation (MD) of the Humphrey field analyzer. Results: Fourteen eyes were classified as the FI type; 52 as the MY type; 17 as the SS type; and 20 as the GE type. The highest correlation coefficients of HRT-II parameters to the MDs was the cup/disc area ratio (r = -0.27) for all groups, the vertical cup/disc ratio (r = -0.42) in the MY group, the maximum cup depth (r = 0.49) in the SS group, and the cup area (r = -0.70) in the GE group. However, none of the parameters was correlated in the FI group. Conclusions:The correlation between the HRT-II parameters and MDs was different for the four disc types. These findings suggest that a classification of optic disc morphology had a benefit for interpreting the measured values of HRT-II.

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Visual field and optic disc progression in patients with different types of optic disc damage

Cited by 68 publications

References 21 publications

Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects

Rates of retinal nerve fibre layer thickness change in glaucoma patients and control subjects

Assessment of rates of structural change in glaucoma using imaging technologies

Correlation between morphology of optic disc determined by Heidelberg Retina Tomograph II and visual function in eyes with open-angle glaucoma

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