Visual Evoked Response in Diagnosis of Multiple Sclerosis

Electrophysiological assessment of optic nerve disease

“…15 They further demonstrated that the VEP could reveal optic nerve conduction delay in the absence of any signs or symptoms of clinical optic nerve involvement. 16 Usually, VEPs showed conduction delay with less marked amplitude change. There was a stronger relationship between visual acuity and any amplitude change than with the magnitude of the conduction delay.…”

Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial

“…Pattern-reversal visual-evoked potentials (VEPs) record cortical responses on the scalp overlying the occipital lobe in response to an alternating repetitive visual stimulus. 23,24 Nearly all patients with multiple sclerosis ultimately exhibit demyelinating damage to the anterior visual pathway 25 and detection of prolongation of VEP latency has been used as supportive evidence to help confirm a clinical diagnosis of multiple sclerosis. 24,26 Research in context Evidence before this study We searched PubMed articles published until Jan 10, 2017, without language restrictions reporting on remyelinating trials and treatments for multiple sclerosis.…”

“…23,24 Nearly all patients with multiple sclerosis ultimately exhibit demyelinating damage to the anterior visual pathway 25 and detection of prolongation of VEP latency has been used as supportive evidence to help confirm a clinical diagnosis of multiple sclerosis. 24,26 Research in context Evidence before this study We searched PubMed articles published until Jan 10, 2017, without language restrictions reporting on remyelinating trials and treatments for multiple sclerosis. In our search, we used the terms "multiple sclerosis" OR "MS" OR "optic neuropathy" OR "visual evoked potential" OR "clemastine" AND "remyelination" initially filtering results for articles that report phase 1, 2, or 3 clinical trials.…”

Whole-Brain Diffusion Tensor Imaging in Correlation to Visual-Evoked Potentials in Multiple Sclerosis: A Tract-Based Spatial Statistics Analysis

“…[6][7][8] However, they failed to provide reliable results in predicting lesions of the retrochiasmal part. 9,10 Evoked potentials, in general, and combined evoked potential analysis, in particular, seem to correlate well with the long-term disability of patients with MS. Correlations of evoked potentials and MR imaging are reported controversially.…”