Visual event‐related potential in mild dementia of the Alzheimer's type

Saito, Hiroko; Yamazaki, Hideki; Matsuoka, Hiroo; Matsumoto, Kazunori; Numachi, Yohtaro; Yoshida, Sumiko; Ueno, Takashi; Sato, Mitsumoto

doi:10.1046/j.1440-1819.2001.00876.x

Cited by 40 publications

(31 citation statements)

References 31 publications

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“…However, the majority of studies used auditory stimuli for ERPs acquisition. Those less frequent studies that examined ERPs to visual stimuli and used classical oddball paradigm are not consistent in their findings regarding differences between patients with AD and normal controls: while Verleger et al [50] did not find any change of visual ERPs in patients with AD, Saito et al [51], Daffner et al [52] and Pokryzsko-Dragan et al [19] reported only reduced P300 amplitudes in patients with AD, and Onofri et al [53] and Everes et al [54] described only prolonged P300 latencies in patients with AD, which was also our case. Further, Polich and Hoffmann [55] found both decreased amplitudes and prolonged latencies in patients with AD.…”

Section: Visual Erpsmentioning

confidence: 94%

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Visual evoked potentials to pattern, motion and cognitive stimuli in Alzheimer’s disease

et al. 2010

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The aim of our study was to verify reported visual dysfunctions of patients with Alzheimer disease with the use of several variants of VEPs and visual ERPs and to learn whether these methods can be useful in diagnostics of AD. We tested 15 patients (6 women and 9 men, aged from 58 to 87) with mild to moderate Alzheimer disease (12-23 points of Mini Mental State Examination) and 15 age, gender and education level matched controls. The examination consisted of VEPs to pattern-reversal and motion-onset stimulation (to translational and radial movement) and of visual ERPs recorded during an odd-ball test. The subjects were instructed to signalize target stimuli by pressing of a button, which enabled to evaluate also the reaction time. While pattern-reversal VEPs were comparable in patients and controls, there were significantly smaller N2 peak amplitudes of motion-onset VEPs in patients with AD (in particular in radial moving stimuli outside the central 20 deg of the visual field), which suggests a dysfunction of the motion-processing (magnocellular) system or the dorsal cortical stream. ERPs, having significantly longer latencies in patients than in controls, distinguished well both groups. However, the individual AD diagnostics based on ERPs seems to be limited by rather high inter-individual variability of the ERP latencies. The ERPs might, however, be useful in disease progress and therapy effect estimation. Electrophysiological parameters did not correlate with neuropsychological ADAS cog test (Alzheimer Disease Assessment Scale--cognitive part).

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Section: Visual Erpsmentioning

confidence: 94%

“…Another difference among the aforementioned studies is that some of them employed mental counting task [53], while the other ones used button (joystick) pressing task [50][51][52]. According to Polich and Corey-Bloom [20], it is more recommendable to perform the pressing tasks since it gives more reliable results.…”

Section: Visual Erpsmentioning

confidence: 99%

Visual evoked potentials to pattern, motion and cognitive stimuli in Alzheimer’s disease

et al. 2010

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“…In this paper we will focus on the P3 component, a well studied component of the ERP that is related to high-level attention-dependent cognitive processing [16][17][18]. Reductions of the P3 component are not uncommon in psychiatric and neurological disorders with cognitive dysfunction like ADHD [19], schizophrenia [20] and dementia [21].…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological Correlates of Information Processing in Breast-Cancer Patients Treated With Adjuvant Chemotherapy

Kreukels

Schagen

Ridderinkhof

et al. 2005

Breast Cancer Res Treat

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Cognitive deficits are found in a number of breast-cancer patients who have undergone adjuvant (Cyclophosphamide, Methotrexate, and 5-Fluorouracil (CMF)) chemotherapy, but the underlying mechanisms are still unclear. The objective of this study is to investigate information processing in these patients with concurrent registration of brain activity. Twenty-six breast-cancer patients treated with adjuvant CMF chemotherapy and a control group of 23 stage I breast-cancer patients not treated with chemotherapy were examined. Mean time since treatment for the CMF patients was 5.1 years after the last CMF course, and for the control patients 3.6 years after termination of radiotherapy. An information processing task was administered with concurrent EEG registration. Reaction times and the amplitudes and latencies of an Event Related Potential component (P3) in different task conditions related to input, central, and output processing of information were studied. Significant differences in latency and amplitude of the P3 component were found between the treatment groups with an earlier and reduced P3 in the chemotherapy group. Patients treated with chemotherapy had longer reaction times (although not significantly different) than the control group on all task conditions. Our data provide further evidence for long-term neurocognitive problems in breast-cancer patients treated with adjuvant (CMF) chemotherapy and offer new information regarding abnormalities in brain functioning in these patients.

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“…These ‘non‐target visual P3s’ may occur when no task is demanded 10 . Non‐target visual P3s may occur, with decreased amplitudes, in patients with dementia of Alzheimer type 11 …”

Section: Introductionmentioning

confidence: 99%

Cognitive resource model for the information‐processing of task‐irrelevant visual stimuli

Saito¹,

Ishida

2002

Psychiatry Clin Neurosci

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In order to elucidate possible factors that effect P3s to task-irrelevant visual stimuli (non-target P3s), we made a normative visual event-related potential study with button-press tasks in four different conditions in which two factors (the number of colors of non-target stimuli, and the shape of the stimuli) were manipulated without any change in task nor target/non-target ratio.The peak distributions of non-target P3s (centrally peaking) were significantly different from those of task-relevant P3s (parietally peaking) in all conditions. The amplitude of non-target P3 decreased as the variety of colors of the non-target stimuli increased. The amplitude of nontarget P3 to colored solid circles was larger than that of non-target P3 to colored Stroop stimuli. Between each condition, task-relevant P3 and reaction time showed no significant difference. Both the variety of non-target stimuli and the shape of the stimuli were shown to have effects on the amplitudes of non-target P3s without any alteration in task-relevant P3s. It is suggested that the amplitude behaviors of non-target P3s partly reflect the amount of cognitive resource allocated for each different kind of task-irrelevant visual stimuli.

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Visual event‐related potential in mild dementia of the Alzheimer's type

Cited by 40 publications

References 31 publications

Visual evoked potentials to pattern, motion and cognitive stimuli in Alzheimer’s disease

Visual evoked potentials to pattern, motion and cognitive stimuli in Alzheimer’s disease

Electrophysiological Correlates of Information Processing in Breast-Cancer Patients Treated With Adjuvant Chemotherapy

Cognitive resource model for the information‐processing of task‐irrelevant visual stimuli

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