Visual/emotional stimuli and treatment with antidepressants alter Numerical Rating Scale score in patients with chronic pain

Kanai, Akifumi; Matsumoto, Shigehiro; Hayashi, Norihito; Shimao, Junko; Nagahara, Yuki

doi:10.1016/j.jclinane.2016.10.027

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…Psychology studies have shown that "green" conveys positive information related to happiness (85). When participants were shown a color before pain stimulation, pain intensity scores were higher than baseline values for all colors, except green (86,87). A clinical study also showed that green light was less likely than other wavelengths of light to exacerbate migraine headache; it even alleviated headache at low intensities (22).…”

Section: Discussionmentioning

confidence: 99%

Green light analgesia in mice is mediated by visual activation of enkephalinergic neurons in the ventrolateral geniculate nucleus

Tang

Liu

et al. 2022

Sci. Transl. Med.

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Green light exposure has been shown to reduce pain in animal models. Here, we report a vision-associated enkephalinergic neural circuit responsible for green light–mediated analgesia. Full-field green light exposure at an intensity of 10 lux produced analgesic effects in healthy mice and in a model of arthrosis. Ablation of cone photoreceptors completely inhibited the analgesic effect, whereas rod ablation only partially reduced pain relief. The analgesic effect was not modulated by the ablation of intrinsically photosensitive retinal ganglion cells (ipRGCs), which are atypical photoreceptors that control various nonvisual effects of light. Inhibition of the retino–ventrolateral geniculate nucleus (vLGN) pathway completely abolished the analgesic effects. Activation of this pathway reduced nociceptive behavioral responses; such activation was blocked by the inhibition of proenkephalin (Penk)–positive neurons in the vLGN (vLGN Penk ). Moreover, green light analgesia was prevented by knockdown of Penk in the vLGN or by ablation of vLGN Penk neurons. In addition, activation of the projections from vLGN Penk neurons to the dorsal raphe nucleus (DRN) was sufficient to suppress nociceptive behaviors, whereas its inhibition abolished the green light analgesia. Our findings indicate that cone-dominated retinal inputs mediated green light analgesia through the vLGN Penk -DRN pathway and suggest that this signaling pathway could be exploited for reducing pain.

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Section: Discussionmentioning

confidence: 99%

Green light analgesia in mice is mediated by visual activation of enkephalinergic neurons in the ventrolateral geniculate nucleus

Tang

Liu

et al. 2022

Sci. Transl. Med.

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“…The following parameters were recorded and analyzed: clinicopathological characteristics, including age, sex, body mass index (BMI), presenting symptoms, surgical duration, intraoperative blood loss, hospital stay, and hospital costs. Postoperative immediate complications, including the Numerical Rating Scale ( 13 ) and the additional use of analgesics, were collected. Postoperative digital anal and anoscopy examinations were conducted at our outpatient department every week until full recovery.…”

Section: Methodsmentioning

confidence: 99%

Outcomes of Modified Tissue Selection Therapy Stapler in the Treatment of Prolapsing Hemorrhoids

et al. 2022

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ObjectiveTissue selection therapy staplers (TSTs) are widely used to treat prolapsing hemorrhoids; however, some disadvantages exist. We describe a modified technique for the treatment of prolapsing hemorrhoids, with the aim of minimizing the risk of anal stenosis and anal incontinence and reducing the impact of postoperative complications from the stapling technique. We applied a modified TST procedure, and the preliminary data were used to test the efficacy and safety of this new technique.MethodsWe conducted a retrospective study of patients who underwent modified TST for prolapsing hemorrhoids at our department between January 2018 and January 2020. All patients received a modified TST. Most prolapsing hemorrhoids were not segmentally resected and were instead selectively removed. The demographics, preoperative characteristics, postoperative complications, therapeutic effects, and patient satisfaction were collected and analyzed.ResultsA total of 106 patients were included in the study; 53 were men and 53 women (mean age, 49.24 years). The mean operative time was 55.01 min, and the mean hospital stay was 7.82 days. After surgery, three patients experienced bleeding (2.83%), 2 patients experienced anal discharge (1.89%), 2 patients experienced tenesmus (1.89%), and 5 patients experienced anal tags (4.72%). Anal incontinence, persistent post stapler pain, rectovaginal fistula and anal stenosis did not occur. Two patients developed recurrent symptomatic hemorrhoids (1.89%). The total effective rate of the surgery and the total satisfaction rate of the patients was 97.17%.ConclusionsThe modified tissue selection therapy stapler technique was a satisfactory and economical treatment for prolapsing hemorrhoids at a follow-up period of 1 year. The modified TST was associated with reduced anal stenosis and anal incontinence, less persistent post stapler pain and a minimal risk of rectovaginal fistula.

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“…2,3 The need to reduce opioid prescription and diversion is currently an important public health issue. 4,5…”

mentioning

confidence: 99%

“…The authors should be applauded for performing a well‐designed study in an important topic (eg, acute pain) in patients undergoing elective surgery 2 , 3 . The need to reduce opioid prescription and diversion is currently an important public health issue 4 , 5 …”

mentioning

confidence: 99%

“…2,3 The need to reduce opioid prescription and diversion is currently an important public health issue. 4,5 Nonetheless, some critical points need to be clarified by the authors to determine the validity of the findings. First, the authors did not report the use of intraoperative opioids in their analysis as this can directly affect the use of postoperative opioids.…”

mentioning

confidence: 99%

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Confounding Factors on the Prediction of Opioid Usage after Thyroidectomy and Parathyroidectomy Surgery

Kang¹

2019

Otolaryngol.--head neck surg.

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Visual/emotional stimuli and treatment with antidepressants alter Numerical Rating Scale score in patients with chronic pain

Cited by 4 publications

References 15 publications

Green light analgesia in mice is mediated by visual activation of enkephalinergic neurons in the ventrolateral geniculate nucleus

Green light analgesia in mice is mediated by visual activation of enkephalinergic neurons in the ventrolateral geniculate nucleus

Outcomes of Modified Tissue Selection Therapy Stapler in the Treatment of Prolapsing Hemorrhoids

Confounding Factors on the Prediction of Opioid Usage after Thyroidectomy and Parathyroidectomy Surgery

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