Visual disturbance due to retinal edema as a complication of imatinib

Optic disc edema as a possible complication of Imatinib mesylate (Gleevec)

“…In the ocular manifestation of edema, periorbital edema and epiphora are the most common complications and retinal edema and optic neuritis have been rarely reported. [3][4][5] In our case, although the patient had a few signs and symptoms of optic neuritis such as photopsia, a few depressed points in visual fi eld, and slight prolongation of P100 latency in VEP, they were not enough to confi rm a diagnosis of optic neuritis. Most complications of imatinib are related to fl uid retention in the connective tissue and extracellular matrix, and associated with inhibition of the platelet-derived growth factor receptor.…”

Bilateral cystoid macular edema in a patient with chronic myeloid leukaemia under treatment with imanitib mesylate: report of an unusual side effect

“…Unilateral retinal involvement has been recently reported twice in the literature [3,4]. In the case reported by Kusumi et al, the OCT pictures provided disclosed the existence of fluid in the subretinal space but no cystoid configuration of it [3]. The case reported by Masood et al concerned a patient under treatment with imanitib who developed unilateral CME after uncomplicated phacoemulsification [4].…”

“…Ocular manifestation of edema is a recognized side effect of imatinib use [2]. Unilateral retinal involvement has been recently reported twice in the literature [3,4]. In the case reported by Kusumi et al, the OCT pictures provided disclosed the existence of fluid in the subretinal space but no cystoid configuration of it [3].…”

“…The case reported by Masood et al concerned a patient under treatment with imanitib who developed unilateral CME after uncomplicated phacoemulsification [4]. In both cases, prompt discontinuance of imanitib led to patient's visual recovery [3,4].…”

Bilateral papilledema on sunitinib therapy for advanced renal cell carcinoma

“…The current literature suggests the development of periorbital edema may be linked to PDGF receptor b inhibition; the receptor is thought to have a role in the regulation of interstitial fluid pressure and is avidly expressed on the dermal dendrocytes of the periorbital tissues [16,17]. A case report of retinal edema by Kusumi et al assumes a similar mechanism related to the expression of PDGF receptors in the retina [18]. No other TKIs have so far been implicated in the literature.…”