Visual detection of melamine in milk samples based on label-free and labeled gold nanoparticles

Huang, Hui; Li, Li; Zhou, Guohua; Liu, Zhihong; Ma, Qiao; Feng, Yu‐Qi; Zeng, Guoping; Tinnefeld, Philip; He, Zhibing

doi:10.1016/j.talanta.2011.05.006

Cited by 63 publications

(30 citation statements)

References 43 publications

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“…Chen et al reported the bare gold nanoparticles as a probe for colorimetric discovery of melamine [100]. Similar to the above method, various label free or citrate-stabilized Au NPs with diverse sizes were reported in melamine discrimination [101][102][103][104][105][106][107][108][109][110][111][112][113][114][115][116]. Similarly, many capped or stabilized Au NPs were testified in melamine identification.…”

Section: Nanoparticles In Melamine Quantificationmentioning

confidence: 93%

Review on Nanomaterial-Based Melamine Detection

Shellaiah

Sun

2019

Chemosensors

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Illegal adulteration of milk products by melamine and its analogs has become a threat to the world. In 2008, the misuse of melamine with infant formula caused serious effects on babies of China. Thereafter, the government of China and the US Food and Drug Administration (FDA) limited the use of melamine of 1 mg/kg for infant formula and 2.5 mg/kg for other dairy products. Similarly, the World Health Organization (WHO) has also limited the daily intake of melamine of 0.2 mg/kg body weight per day. Many sensory schemes have been proposed by the scientists for carrying out screening on melamine poisoning. Among them, nanomaterial-based sensing techniques are very promising in terms of real-time applicability. These materials uncover and quantify the melamine by means of diverse mechanisms, such as fluorescence resonance energy transfer (FRET), aggregation, inner filter effect, surface-enhanced Raman scattering (SERS), and self-assembly, etc. Nanomaterials used for the melamine determination include carbon dots, quantum dots, nanocomposites, nanocrystals, nanoclusters, nanoparticles, nanorods, nanowires, and nanotubes. In this review, we summarize and comment on the melamine sensing abilities of these nanomaterials for their suitability and future research directions.

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Section: Nanoparticles In Melamine Quantificationmentioning

confidence: 93%

Review on Nanomaterial-Based Melamine Detection

Shellaiah

Sun

2019

Chemosensors

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“…When non‐aggregated AuNPs react with NaCl and begin to aggregate, a sharp colour change from red to purple is observed. This method can be used to detect melamine in raw milk at concentrations as low as 41.7 nmol L −1 within 10 min . AuNP methods can also be enhanced to achieve the real‐time detection of melamine in dairy products.…”

Section: The Melamine Adulteration Incident In Chinamentioning

confidence: 99%

“…This method can be used to detect melamine in raw milk at concentrations as low as 41.7 nmol L −1 within 10 min. 101 AuNP methods can also be enhanced to achieve the real-time detection of melamine in dairy products. In this assay, 1-(2-mercaptoethyl)-1,3,5-triazinane-2,4,6-trione (MTT) is used to make MTT-stabilized AuNPs.…”

Section: Colorimetric Sensormentioning

confidence: 99%

Adverse child health impacts resulting from food adulterations in the Greater China Region

Chow

2017

J Sci Food Agric

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Food adulteration has a long history in human society, and it still occurs in modern times. Because children are relatively vulnerable to food adulterants, studying the health impacts of food adulteration on children is important. This article provides an overview of the child health impacts of food adulterants in two recent food adulteration incidents in the Greater China Region: (1) a plasticizer incident in Taiwan and (2) a 2,4,6-triamino-1,3,5-triazine (melamine)-tainted milk incident in China. The involved food adulterants, di-(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DiNP) and melamine, are harmful to the hippocampus, kidneys, reproductive organs and immune system of children, and they also increase the risk of cancer. To detect food adulteration and to avoid further harm caused by food adulteration, simple screening methods have been developed, and they have recently emerged as a new focus area for research. This article also summarizes the simple screening methods used to analyse the aforementioned food adulterants and reports how governments reacted to the recent food incidents. © 2017 Society of Chemical Industry.

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“…Recently, some papers have reported that melamine can form T-melamine-T mismatches in oligonucleotides by triple hydrogen bonding with thymine base [ 23 , 24 , 25 , 26 ]. Furthermore, SYBR Green I can exhibit a dramatic enhancement upon binding to double-stranded DNA [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Simple and Label-Free Fluorescent Detection of Melamine Based on Melamine–Thymine Recognition

Yang

Wang

et al. 2018

Sensors

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In the past few years, melamine has been illegally added into dairy products to increase the apparent crude protein levels. If humans or animals drink the milk adulteration of melamine, it can form insoluble melamine–cyanurate crystals in their kidneys which causes kidney damage or even death. In the present work, we constructed a simple and label-free fluorescent method for melamine detection based on melamine-thymine recognition. SYBR Green I was utilized as a reporter for this method as it did not require any modification or expensive equipment. In the absence of melamine, polythymine DNA was digested by Exo I, which caused a decrease in the fluorescence signal. In the presence of melamine, the polythymine DNA was able to fold into a double chain structure, however this was done with the help of T-melamine-T mismatches to prevent degradation. Then, the SYBR Green I combined with the double-stranded DNA to result in an intense fluorescence signal. The limit of detection in this method was 1.58 μM, which satisfied the FDA standards. This method also had a good linear relationship within the range of 10–200 μM. In addition, this new method has a good selectivity to distinguish melamine from the component of milk. As a result, we developed a simple and highly selectivity method for melamine detection.

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Visual detection of melamine in milk samples based on label-free and labeled gold nanoparticles

Cited by 63 publications

References 43 publications

Review on Nanomaterial-Based Melamine Detection

Review on Nanomaterial-Based Melamine Detection

Adverse child health impacts resulting from food adulterations in the Greater China Region

Simple and Label-Free Fluorescent Detection of Melamine Based on Melamine–Thymine Recognition

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