Visual cortex reactivity in sedated children examined with perfusion MRI (FAIR)

Born, Alfred Peter; Rostrup, Egill; Miranda, María J; Larsson, Henrik; Lou, Hans Olav Christensen

doi:10.1016/s0730-725x(02)00469-1

Cited by 70 publications

(42 citation statements)

References 24 publications

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“…Indeed, Born et al [2002a] reported a negative BOLD response in the primary visual cortex during photostimulation due to a decrease in rCBF in sedated children. Born et al [2002b] also observed patterns of activation of the adult ᭜ Visual Hemodynamic Responses in Infants ᭜ visual cortex using fMRI and PET.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive optical imaging in the visual cortex in young infants

Kusaka

Kawada

Okubo

et al. 2004

Human Brain Mapping

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During the developmental stage, the brain undergoes anatomic, functional, and metabolic changes necessary to support the complex adaptive behavior of a mature individual. Estimation of developmental changes occurring in different regions of the brain would provide a means of relating various behavioral phenomena to maturation-specific brain structures, thereby providing useful information on structure-function relationships in both normal and disease states. We used multichannel near-infrared spectroscopy (MNIRS), a new noninvasive imaging technique for revealing the course of neural activity in selected brain regions, to monitor the activities of the visual cortex as mirrored by hemodynamic responses in infants subjected to photostimulation during natural sleep. In the infants, oxyhemoglobin and total hemoglobin decreased and deoxyhemoglobin increased in the visual cortex with photostimulation. This pattern of responses was different from the response pattern in adults reported previously. The different patterns of responses to photostimulation in the visual cortices of infants and adults might reflect developmental and behavioral differences. It may reflect a different functional organization of the visual cortex in infants or ongoing retinal development. Our results demonstrated that regional hemodynamic change could be detected in a small area around the visual cortex. MNIRS offers considerable potential for research and noninvasive clinical applications. Hum. Brain Mapp. 22:122-132, 2004.

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Section: Discussionmentioning

confidence: 99%

Noninvasive optical imaging in the visual cortex in young infants

Kusaka

Kawada

Okubo

et al. 2004

Human Brain Mapping

View full text Add to dashboard Cite

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“…14 fMRI studies of infants have found both negative and positive BOLD responses in response to sensory stimuli. [15][16][17][18][19][20] In contrast to BOLD-fMRI, NIRS can measure oxy-͑HbO 2 ͒, deoxy-͑HbR͒, 21 and total hemoglobin ͑HbT͒, providing a more comprehensive view of brain metabolism, [22][23][24] even in situations of altered neurovascular coupling. HbT provides a relatively robust indicator of CBV, while the ratio of HbO 2 and HbT reflects StO 2 .…”

Section: Introductionmentioning

confidence: 99%

Neonatal hemodynamic response to visual cortex activity: high-density near-infrared spectroscopy study

et al. 2010

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Abstract. The neurodevelopmental outcome of neonatal intensive care unit ͑NICU͒ infants is a major clinical concern with many infants displaying neurobehavioral deficits in childhood. Functional neuroimaging may provide early recognition of neural deficits in high-risk infants. Near-infrared spectroscopy ͑NIRS͒ has the advantage of providing functional neuroimaging in infants at the bedside. However, limitations in traditional NIRS have included contamination from superficial vascular dynamics in the scalp. Furthermore, controversy exists over the nature of normal vascular, responses in infants. To address these issues, we extend the use of novel high-density NIRS arrays with multiple source-detector distances and a superficial signal regression technique to infants. Evaluations of healthy term-born infants within the first three days of life are performed without sedation using a visual stimulus. We find that the regression technique significantly improves brain activation signal quality. Furthermore, in six out of eight infants, both oxy-and total hemoglobin increases while deoxyhemoglobin decreases, suggesting that, at term, the neurovascular coupling in the visual cortex is similar to that found in healthy adults. These results demonstrate the feasibility of using high-density NIRS arrays in infants to improve signal quality through superficial signal regression, and provide a foundation for further development of highdensity NIRS as a clinical tool.

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“…16-23 Also, a handful of functional MRI (fMRI) studies of neonates have shown an age-dependent change in the functional signal response to visual stimulation. [24][25][26][27][28][29] Longitudinal MRI studies of human neonates are rare. 30 While human newborns within the first 2 postnatal weeks can be fed, swaddled, and put to sleep then into the MR scanner, older neonates are usually scanned at night or during their nap time.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared frequency-domain optical spectroscopy and magnetic resonance imaging: a combined approach to studying cerebral maturation in neonatal rabbits

et al. 2005

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The neonatal rabbit brain shows prolonged postnatal development both structurally and physiologically. We use noninvasive near-IR frequency-domain optical spectroscopy (NIRS) and magnetic resonance imaging (MRI) to follow early developmental changes in cerebral oxygenation and anatomy, respectively. Four groups of animals are measured: NIRS in normals, MRI in normals, and both NIRS and MRI with hypoxia-ischemia (HI) (diffusion MRI staging). NIRS and/or MRI are performed from P3 (postnatal day=P) up to P76. NIRS is performed on awake animals with a frequency-domain tissue photometer. Absolute values of oxyhemoglobin concentration ([HbO 2 ]), deoxyhemoglobin concentration ([HbR]), total hemoglobin concentration (HbT), and hemoglobin saturation (StO 2 ) are calculated. The brains of all animals appeared to be maturing as shown in the diffusion tensor MRI. Mean optical coefficients (reduced scattering) remained unchanged in all animals throughout. StO 2 increased in all animals (40% at P9 to 65% at P43) and there are no differences between normal, HI controls, and HI brains. The measured increase in StO 2 is in agreement with the reported increase in blood flow during the first 2 months of life in rabbits. HbT, which reflects blood volume, peaked at postnatal day P17, as expected since the capillary density increases up to P17 when the microvasculature matures.

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Visual cortex reactivity in sedated children examined with perfusion MRI (FAIR)

Cited by 70 publications

References 24 publications

Noninvasive optical imaging in the visual cortex in young infants

Noninvasive optical imaging in the visual cortex in young infants

Neonatal hemodynamic response to visual cortex activity: high-density near-infrared spectroscopy study

Near-infrared frequency-domain optical spectroscopy and magnetic resonance imaging: a combined approach to studying cerebral maturation in neonatal rabbits

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