Visual cortex neural activity alteration in cervical spondylotic myelopathy patients: a resting-state fMRI study

Chen, Zhao; Wang, Qiu; Liang, Meng; Zhao, Rui; Zhu, Jiajia; Xiong, Wuyi; Su, Zhe; Yu, Chunshui; Xue, Yuan

doi:10.1007/s00234-018-2061-x

Cited by 38 publications

(39 citation statements)

References 36 publications

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“…At first glance, the identification of visual cortical connectivity differences may seem surprising given that CM is not a primary visual disorder. However, a recent study that investigated preoperative visual cortex neural activity and FC alterations in CSM patients revealed the differences between the visual cortex and the posterior cingulate gyrus 18 . Although there is a difference in the location of clusters, CM patients may exhibit changes in the FC of the visual cortex with some clusters.…”

Section: Discussionmentioning

confidence: 98%

“…Previous studies exploring the use of MRI in CM have analysed only preoperative FCs or FCs of a specific anatomical region (e.g., sensorimotor cortex) 16,17 . Although a previous study investigated preoperative visual cortex neural activity and FC alterations in cervical spondylotic myelopathy (CSM) patients 18 , no studies have investigated postoperative changes in FCs across whole brain networks or the correlation between FC changes and clinical recovery. If such a correlation is established, then it might lead to a useful biomarker for decision-making of surgical indication.…”

Section: Introductionmentioning

confidence: 99%

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Towards prognostic functional brain biomarkers for cervical myelopathy: A resting-state fMRI study

Takenaka

Kan

Seymour

et al. 2019

Sci Rep

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Recently, there has been increasing interest in strategies to predict neurological recovery in cervical myelopathy (CM) based on clinical images of the cervical spine. In this study, we aimed to explore potential preoperative brain biomarkers that can predict postoperative neurological recovery in CM patients by using resting-state functional magnetic resonance imaging (rs-fMRI) and functional connectivity (FC) analysis. Twenty-eight patients with CM and 28 age- and sex-matched healthy controls (HCs) underwent rs-fMRI (twice for CM patients, before and six months after surgery). A seed-to-voxel analysis was performed, and the following three statistical analyses were conducted: (i) FC comparisons between preoperative CM and HC; (ii) correlation analysis between preoperative FCs and clinical scores; and (iii) postoperative FC changes in CM. Our analyses identified three FCs between the visual cortex and the right superior frontal gyrus based on the conjunction of the first two analyses [(i) and (ii)]. These FCs may act as potential biomarkers for postoperative gain in the 10-second test and might be sufficient to provide a prediction formula for potential recovery. Our findings provide preliminary evidence supporting the possibility of novel predictive measures for neurological recovery in CM using rs-fMRI.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Towards prognostic functional brain biomarkers for cervical myelopathy: A resting-state fMRI study

Takenaka

Kan

Seymour

et al. 2019

Sci Rep

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“…MOG is associated with visual information processing. A recent resting-state fMRI study has reported that the amplitude of low-frequency fluctuations and regional homogeneity in the occipital lobe are decreased in patients with CSM ( Chen et al, 2018 ). The two resting-state functional measures indicate functional activity oscillations ( Zang et al, 2007 ) and synchronization of neurons ( Zang et al, 2004 ), respectively.…”

Section: Discussionmentioning

confidence: 99%

Altered Topological Properties of Brain Structural Covariance Networks in Patients With Cervical Spondylotic Myelopathy

Kuang

Zha

Liu

et al. 2020

Front. Hum. Neurosci.

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Background: Brain structural alterations play an important role in patients with cervical spondylotic myelopathy (CSM). However, while there have been studies on regional brain structural alterations, only few studies have focused on the topological organization of the brain structural covariance network. This work aimed to describe the structural covariance network architecture alterations that are possibly linked to cortex reorganization in patients with CSM. Methods: High-resolution anatomical images of 31 CSM patients and 31 healthy controls (HCs) were included in the study. The images were acquired using a sagittal three-dimensional T1-weighted BRAVO sequence. Firstly, the gray matter volume of 90 brain regions of automated anatomical labeling atlas were computed using a VBM toolbox based on the DARTEL algorithm. Then, the brain structural covariance network was constructed by thresholding the gray matter volume correlation matrices. Subsequently, the network measures and nodal property were calculated based on graph theory. Finally, the differences in the network metrics and nodal property between groups were compared using a non-parametric test. Results: Patients with CSM showed larger global efficiency and smaller local efficiency, clustering coefficient, characteristic path length, and sigma values than HCs. Patients with CSM had greater betweenness in the left superior parietal gyrus (SPG.L) and the left supplementary motor area (SMA.L) than HCs. Besides, patients with CSM had smaller betweenness in right middle occipital gyrus. The brain structural covariance networks of CSM patients exhibited equal resilience to random failure as those of HCs. However, the maximum relative size of giant connected components was approximately 10% larger in HCs than in CSM patients, upon removal of 44 nodes in targeted attack. Conclusion: These observed alternations in global network measures in CSM patients reflect that the brain structural covariance network in CSM exhibits the less optimal small-world model compared to that in HCs. Increased betweenness in SPG.L and

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“…However, these studies were all hypothesis-driven analyses of some brain region as the specific cortex. Recently, a rs-fMRI study based on data-driven analyses demonstrated that the ALFF/ReHo values in the occipital lobe were decreased and the functional connectivity between the visual cortex and posterior cingulate gyrus was increased in 27 patients with CSM as compared with those of 11 healthy controls (HCs) 21…”

Section: Introductionmentioning

confidence: 99%

“…Subsequently, we assessed the relationship between clinical performance and the altered ALFF, ReHo, and functional connectivity in patients with CSM. Although a previous study21 discussed the alterations in resting-state functional activity in patients with CSM, it mainly focused on exploring the relationship of the resting-state-related alternations with visual disorders, and the number of patients with CSM and HCs were not well-matched. Therefore, we aimed to contribute to the current literature on cortical reorganization in patients with CSM by using larger and number-matched study groups in order to identify more elaborate central activity alterations linked to CSM.…”

Section: Introductionmentioning

confidence: 99%

<p>Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study</p>

Kuang¹,

Zha²

2019

NDT

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PurposeWe employed resting-state fMRI analyses to reveal central functional reorganization in the brains of patients with cervical spondylotic myelopathy (CSM) and to provide complementary evidence of cortex reorganization in these patients.Patients and methodsWe obtained Fisher’s z transformation amplitude of low-frequency fluctuations (zALFF) and Fisher’s z transformation regional homogeneity (zReHo) measurements from 33 patients with CSM and 33 healthy controls (HC) and used the brain regions with significant alterations in the zALFF or zReHo values as seed regions. Then, we calculated Pearson’s correlation coefficients between the resting-state time courses of each seed and the time series of the rest of the brain. Lastly, we computed correlations between the altered zALFF, zReHo, and functional connectivity with Japanese Orthopaedic Association scores, Neck Disability Index score, and the duration of symptoms in patients with CSM.ResultszALFF and zReHo values were increased in the left medial superior frontal gyrus (lSFGmed) and left supramarginal gyrus (lSMG) in patients with CSM compared with those in the HC group. Selecting lSFGmed as the seed, we observed increased functional connectivity between it and the left postcentral gyrus (lPoCG) and left rolandic operculum and decreased functional connectivity with the right medial superior frontal gyrus in patients with CSM. In addition, there was a significant increase in the functional connectivity between the lSMG (seed) and the left calcarine and lPoCG in patients with CSM. However, we did not find any significant correlation between the resting-state findings and the clinical performance of patients with CSM.ConclusionThese observed intrinsic functional changes in the patients with CSM may be related to functional reorganization and reflect the innate cortical plasticity in patients with CSM. Notably, the increased connectivity between the lPoCG and the two seed ROIs indicates the adaptive changes in patients with CSM. These findings provide complementary evidence of cortex reorganization in CSM.

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Visual cortex neural activity alteration in cervical spondylotic myelopathy patients: a resting-state fMRI study

Abstract: Both ALFF/ReHo value changes and positive correlations of these changes with BCVA were demonstrated in CSM. The FC between the visual cortex and posterior cingulate lobe was also increased in CSM.

Cited by 38 publications

References 36 publications

Towards prognostic functional brain biomarkers for cervical myelopathy: A resting-state fMRI study

Towards prognostic functional brain biomarkers for cervical myelopathy: A resting-state fMRI study

Altered Topological Properties of Brain Structural Covariance Networks in Patients With Cervical Spondylotic Myelopathy

<p>Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study</p>

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