Visual Attention to Features and Space in Mice Using Reverse Correlation

Lehnert, Jonas; Cha, Kuwook; Halperin, Jaime; Yang, Kerry; Zheng, Daniel F.; Khadra, Anmar; Cook, Erik P.; Krishnaswamy, Arjun

doi:10.2139/ssrn.4277950

Cited by 1 publication

(2 citation statements)

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“…Our demonstration of reward historyguided attention for whisker touch in mice establishes a novel model for studying the neurobiological mechanisms of attentional capture. This model complements recent visual tasks to study top-down [44][45][46][47][48][49] and bottom-up [49][50] attention in head-fixed mice, and thus may reveal the extent to which common neurobiological mechanisms are engaged in different forms of attention and different sensory modalities.…”

Section: Discussionmentioning

confidence: 74%

“…Summary data are reported as mean ± SEM, unless otherwise specified. Population means were compared using permutation tests, corrected for multiple comparisons (False Discovery Rate correction 48 ) as needed. To compare population means with multiple subgroups, we first assessed whether a main effect was present using a permutation test, and then performed post hoc tests for pairwise means, correcting for multiple comparisons (with False Discovery Rate correction).…”

Section: Statistical Analysis Of Summary Datamentioning

confidence: 99%

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Reward history cues focal attention in whisker somatosensory cortex

Ramamurthy,

Rodriguez,

Cen

et al. 2024

Preprint

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The history of stimuli and rewards in the recent past drives an automatic form of attention in animals and humans in which attentional priority is given to previously rewarded stimuli. The neurobiological basis for this form of attention is unknown. In a novel whisker touch detection task, we show that mice flexibly shift attention between specific whiskers, based on this recent history of stimulus-reward association. 2-photon calcium imaging and spike recordings revealed a robust neurobiological correlate in somatosensory cortex (S1), involving topographically precise, whisker-specific boosting of L2/3 pyramidal (PYR) cell sensory responses to attend whiskers, and receptive fields shifts towards attended whiskers. L2/3 VIP interneurons were activated by whisker stimuli and arousal but did not carry a whisker-specific attentional signal, so do not mediate this form of attention. Thus, reward history drives attentional capture that is associated with dynamic, topographically precise modulation of sensory evoked activity in S1.

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