Visual and proprioceptive feedback mechanisms of precision manual motor control in autism spectrum disorder

Abstract

Background Individuals with Autism Spectrum Disorder (ASD) show deficits processing sensory feedback to reactively adjust ongoing motor behaviors. Atypical reliance on visual and proprioceptive feedback each have been reported during motor behaviors in ASD suggesting that impairments are not specific to one sensory domain but may instead reflect a deficit in multisensory processing, resulting in reliance on unimodal feedback. The present study tested this hypothesis by examining motor behavior across different visual and proprioceptive feedback conditions during a visually guided precision grip force test. Methods Participants with ASD (N = 43) and age-matched typically developing (TD) controls (N = 23), range 10–20 years, completed a test of precision gripping. They pressed on force sensors with their index finger and thumb while receiving visual feedback on a computer screen in the form of a horizontal bar that moved upwards with increased force. They were instructed to press so that the bar reached the level of a static target bar and then to hold their grip force as steadily as possible. Visual feedback was manipulated by changing the gain of the force bar. Proprioceptive feedback was manipulated by applying 80 Hz tendon vibration at the wrist to induce an illusion of muscle elongation. Force variability (standard deviation) and irregularity (sample entropy) were examined using multilevel linear models. Results While TD controls showed increased force variability with the tendon vibration on compared to off, individuals with ASD showed similar levels of force variability across tendon vibration conditions. Individuals with ASD showed stronger age-associated reductions in force variability relative to controls across conditions. The ASD group also showed greater age-associated increases in force irregularity relative to controls, especially at higher gain levels and when the tendon vibrator was turned on. Conclusions Our findings that individuals with ASD show similar levels of force variability and regularity during induced proprioceptive illusions suggest a reduced ability to integrate proprioceptive feedback information to guide ongoing precision manual motor behavior. We also document stronger age-associated gains in force control in ASD relative to TD suggesting delayed development of multisensory feedback control of motor behavior.