Visual and computer-based analysis of 24 h sleep-waking patterns in the dog

Wauquier, A.; Verheyen, Jef; Broeck, W.A.E. Van Den; Janßen, Paul

doi:10.1016/0013-4694(79)90047-6

Cited by 48 publications

(27 citation statements)

References 13 publications

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“…Dogs' sleep EEG spectrum resembled that of human subjects and was generally in accordance with previous literature using invasive technology (Wauquier et al 1979). Namely, drowsiness in dogs and calm awake + S1 in humans was characterized by an increased activity in the high frequency (alpha, beta) range, while in both dogs and humans SWS was characterized by an increased activity in the low frequency (delta) range and REM sleep was characterized by an increased activity in the theta range compared to the other sleep stages (Fig.…”

Section: Resultssupporting

confidence: 88%

“…The relative power spectrum of the EEG signal of the Fz-Cz derivation was calculated separately for the three vigilance states in the frequency ranges of delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz) and beta (12-30 Hz) known from human and rat sleep studies (Colrain 2011) and also previously used in laboratory dogs (Wauquier et al 1979) To compare the spectral features of the sleep EEG after a behaviorally active vs. passive day paired sampled t tests (with Benjamini false discovery rate correction: Benjamini et al 2001) were used. All statistical tests were carried out with SPSS18 (IBM USA).…”

Section: Methodsmentioning

confidence: 99%

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Development of a non-invasive polysomnography technique for dogs (Canis familiaris)

Kis¹,

Szakadát²,

Kovács³

et al. 2014

Physiology & Behavior

161

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Recently dogs (Canis familiaris) have been demonstrated to be a promising model species for studying human behavior as they have adapted to the human niche and developed human-like socio-cognitive skills. Research on dog behavior, however, has so far almost exclusively focused on awake functioning.Here we present a self-developed non-invasive easily replicable canine polysomnography method. N=22 adult pet dogs (with their owners present) and N=12 adult humans participated in Study I. From these subjects N=7 dogs returned on two more occasions for Study II.In Study I. we give a descriptive analysis of the sleep electroencephalogram of the dog and compare it to human data. In order to validate our canine polysomnography method in Study II. we compare the sleep macrostructure and the EEG spectrum of dogs after a behaviorally active versus passive day.In Study I. we found that dogsʼ sleep EEG resembled that of human subjects and was generally in accordance with previous literature using invasive technology. In Study II. we show that similarly to previous results on humans daytime load of novel experiences affects the macrostructural and spectral aspects of subsequent sleep.Our results validate the family dog as a model species for studying the effects of pre-sleep activities on the EEG pattern under natural conditions and thus broaden the perspectives of the rapidly growing fields of canine cognition and sleep research.

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Section: Resultssupporting

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Development of a non-invasive polysomnography technique for dogs (Canis familiaris)

Kis¹,

Szakadát²,

Kovács³

et al. 2014

Physiology & Behavior

161

View full text Add to dashboard Cite

show abstract

“…Power spectral analysis of 4 channels was done on-line with the aid of a PDP 11/E10 minicomputer system (Digital Equipment Corporation) (10). In short, the EEG-signal (7 channels) is digitized in the analogue to a digital converter and processed by the computer.…”

Section: Surgerymentioning

confidence: 99%

Neuropharmacological comparison between domperidone and metoclopramide.

1981

Self Cite

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Abstract-Domperidone, a new gastrokinetic with potent antiemetic properties is devoid of central effects, up to high dose levels. To assess the CNS activity of domperidone and metoclopramide, the inhibition of intracranial self-stimulation (ICS) in two different situations, and the influence on EEG in dogs were studied. The dissociation between the antiemetic and central effects of both compounds were evaluated in dogs given a stereotypogenic dose of apomorphine. A significant and dose related inhibition of ICS (conditioned situation) was obtained with 0.8 and 1.6 mg/kg i.v. domperidone and with 0.125, 0.25 and 0.50 mg/kg i.v. metoclopramide. The ED50 values were 0.79 mg/kg and 0.25 mg/kg respectively. The effect was most pronounced 4 hr after administration with domperidone and 15 min after administration with metoclopramide. In the EEG studies, no specific structure-related effects were found but the total potency was increased with domperidone 0.8 and 1.6 mg/kg i.v. and with metoclopramide 0.063, 0.125, 0.25 and 0.50 mg/kg i.v. This increase was due to a decrease in fast frequencies, an increase of slower frequencies and a slight increase of the amplitude. Sleep-like patterns were not observed with either compound. In the apomorphine-test in dogs, the ratio between the i.v. ED50 values for antagonism of stereotypy and of emesis was 180 (1.8/0.01) for domperidone and 2.67 (0.64/0.24) for metoclopramide. Thus, central effects and antiemetic effects are concomitant with metoclopramide, whereas with domperidone, extremely large doses are required to obtain central effects.dihydro-2H benzimidazol-2-one, is a new gastrokinetic with potent antiemetic properties. Domperi done is reportedly effective for functional gastrointestinal disorders, such as dyspepsia, gastroesophageal reflux, nausea and vomiting (1-2). inhibited the relaxation induced by intra arterial dopamine (3). The latter experiment suggests that dopamine is involved in the local feedback control of gastric motility and that the gastrokinetic effect of dom peridone can be explained by its interference with dopamine receptors, at the level of the stomach.

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“…In dogs five stages of the sleep-wakefulness cycle are distin guished: wakefulness, transition to sleep (or drowsiness), light slow wave sleep, deep slow wave sleep and REM sleep as describe exten sively in Wauquier et al [1979]. Although visual analysis of the EEG remains necessary and appropriate, visual analysis of the EEG remains necessary and appropriate, it is time-consuming and suffers from subjective unreliability.…”

Section: Methodsmentioning

confidence: 99%

Drug Effects on Sleep-Wakefulness Patterns in Dogs

Wauquier¹

1983

Neuropsychobiology

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Sleep-wakefulness patterns in dogs were studied using computerized on-line analysis and off-line sleep stage classification. A short description of the methods is given and the results of the analysis are discussed, touching on the problem of similarities and dissimilarities with sleep-wakefulness patterns in cats. Examples are given of species differences with respect to the effects of narcotic analgesics. The predictability of results obtained in the dog with respect to humans is discussed using as an example the sedative effects of antihistamines and the absence of such effects in response to a specific H₁-antagonist, astemizole. The role of neuro transmitters in sleep is studied, especially the role of dopamine by using dopamine antagonists (pimozide, domperidone) and dopamine agonists (apomorphine).

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Visual and computer-based analysis of 24 h sleep-waking patterns in the dog

Cited by 48 publications

References 13 publications

Development of a non-invasive polysomnography technique for dogs (Canis familiaris)

Development of a non-invasive polysomnography technique for dogs (Canis familiaris)

Neuropharmacological comparison between domperidone and metoclopramide.

Drug Effects on Sleep-Wakefulness Patterns in Dogs

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