Vision-targeted health related quality of life in older adults: patient-reported visibility problems in low luminance activities are more likely to decline than daytime activities

Owsley, Cynthia; McGwin, Gerald

doi:10.1186/s12886-016-0274-5

Cited by 25 publications

(30 citation statements)

References 34 publications

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“…Further, when analysis is limited to the three studies with the full set of NEI-VFQ-25 subscale scores (i.e., SCORE2, CRUISE and BRAVO), the mean subscale scores are highly correlated with each other, with rank correlation coefficients ranging from 0.97 to 0.99. Similarly, the mean subscale scores of the normal vision populations studied by Mangione, 10 Owsley, 15 and Chia 16 are highly correlated, with coefficients ranging from 0.86 to 0.97. In contrast, correlations between the three retinal vein occlusion and three normal vision reference groups are weaker, ranging from 0.67 to 0.80.…”

Section: Resultsmentioning

confidence: 92%

“…10,15,16 Each of the 3 normal vision reference populations was an elderly population, similar to SCORE2, and all had approximately 20/20 vision (Table 1). The NEI-VFQ-25 scores of the 3 normal vision reference populations were similar to each other, and all mean NEI-VFQ-25 subscale scores in these populations were higher than those observed in SCORE2 participants (Table 5A).…”

Section: Resultsmentioning

confidence: 99%

“…P-values from statistical tests examining these relationships were adjusted for multiple testing to ensure family-wide error of 0.05 within each table according to a method in which the p-values of an ensemble of t-tests or correlations are adjusted based on the simulated distribution of the minimum p-value in the ensemble under a permutational hypothesis. 14 NEI-VFQ-25 scores from SCORE2 participants were also compared to normal vision populations from three different studies 10,15,16 and to baseline NEI-VFQ-25 scores observed in four retinal vein occlusion clinical trial populations; two in CRVO, the CRUISE 17,18 (Ranibizumab for the Treatment of Macular Edema after Central Retinal Vein Occlusion Study: Evaluation of Efficacy and Safety; ClinicalTrials.gov identifier NCT00485836) and COPERNICUS 19 (Vascular Endothelial Growth Factor Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion; ClinicalTrials.gov identifier NCT00943072) trials; and two in branch retinal vein occlusion (BRVO), the BRAVO 17,20 (Ranibizumab for the Treatment of Macular Edema after Branch Retinal Vein Occlusion: Evaluation of Efficacy and Safety; ClinicalTrials.gov identifier NCT00486018), and VIBRANT 21 (Study to Assess the Clinical Efficacy and Safety of Intravitreal Aflibercept Injection in Patients with Branch Retinal Vein Occlusion; ClinicalTrials.gov identifier NCT01521559) trials, based on Bonferroni-corrected t-tests and confidence intervals to ensure family-wide error of 0.05 within each table or figure. SAS versions 9.3 and 9.4 (SAS Inc, Cary, North Carolina) were used to conduct statistical analyses.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

SCORE2 Report 5: Vision-Related Function in Patients With Macular Edema Secondary to Central Retinal or Hemiretinal Vein Occlusion

Figueroa

Oden

et al. 2017

American Journal of Ophthalmology

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

SCORE2 Report 5: Vision-Related Function in Patients With Macular Edema Secondary to Central Retinal or Hemiretinal Vein Occlusion

Figueroa

Oden

et al. 2017

American Journal of Ophthalmology

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“…As a result, there has been a notable emphasis in the recent literature on the importance of such measures across the fields of medicine, particularly in ophthalmology. 4 , 14 – 18 Currently, the National Eye Institute's Visual Function Questionnaire-25 (NEI VFQ-25) is the most widely used PRO for measuring vision-related quality of life. 16 However, a majority of its questions refer to daytime activities.…”

mentioning

confidence: 99%

Association of Low Luminance Questionnaire With Objective Functional Measures in Early and Intermediate Age-Related Macular Degeneration

Thompson

Luhmann

Stinnett

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PurposeTo determine whether Low Luminance Questionnaire (LLQ) scores are associated with objective measures of visual function in early and intermediate age-related macular degeneration (AMD).MethodsCross-sectional study of subjects with early AMD Age-Related Eye Disease Study (AREDS) stage 2, N = 33), intermediate AMD (AREDS stage 3, N = 47), and age-matched healthy controls (N = 21). Subjects were interviewed with the LLQ. Psychophysical tests performed included best-corrected visual acuity (BCVA), mesopic microperimetry, dark adaptometry (DA), low luminance visual acuity (LLVA), and cone contrast test (CCT). Low luminance deficit (LLD) was the difference in the number of letters read under photopic versus low luminance settings. The relationship between LLQ and visual function test scores was assessed with linear regression.ResultsSubjects with intermediate AMD had significantly lower LLQ composite scores (mean = 75.8 ± 16.7; median = 76, range [29, 97]) compared with early AMD (mean = 85.3 ± 13.3; median = 88, range [50, 100], P = 0.007) or controls (mean = 91.4 ± 6.5; median = 94, range [79, 99], P < 0.001) in the overall cohort. LLQ composite scores were associated with computerized BCVA (β = 0.516), computerized LLVA at two background luminance (1.3 cd/m2, β = 0.660; 0.5 cd/m2, β = 0.489) along with their respective computerized LLDs (β = −0.531 and −0.467), rod intercept (β = −0.312), and CCT green (β = 0.183) (all P < 0.05). Only the computerized LLVAs and computerized LLDs remained statistically significant after adjusting for AMD versus control status (P < 0.05). Among AMD subjects, LLQ composite scores were significantly associated with the computerized LLVAs (β = 0.622 and 0.441) and LLDs (β = −0.795 and −0.477) at both the 1.3 and 0.5 cd/m2 luminance levels, respectively, and these associations remained significant after adjusting for AMD severity (P < 0.05).ConclusionsAmong subjects with early and intermediate AMD, LLQ scores were significantly associated with computerized LLVA and LLD. LLQ is a useful patient-centered functional measure of visual impairment in early and intermediate AMD.

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“…They had more difficulties with moving around in dim lighting, loss of peripheral vision, and declining driving ability and confidence. Owsley et al 26 also found that adults 60 years of age and older even with normal macular health generally reported notable declines in their vision-related quality of life after 3 years, especially with seeing at night and under low luminance condition.…”

Section: Discussionmentioning

confidence: 95%

Treated PDR Reveals Age-Appropriate Vision Deterioration But Distorted Retinal Organization

Chen

Omari

Hwang

et al. 2020

Trans. Vis. Sci. Tech.

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Citation: Chen XD, Omari A, Hwang M, Kwark L, Dakki N, Farsiu S, Gardner TW. Treated PDR reveals age-appropriate vision deterioration but distorted retinal organization. Trans Vis Sci Tech. 2020;9(3):3, https://doi.org/10. 1167/tvst.9.3.3 Purpose: We determined the progression of visual function, macular structure, and quality of life in patients with regressed proliferative diabetic retinopathy (PDR) after panretinal photocoagulation (PRP). Methods:In this prospective study, 22 patients who underwent PRP for PDR and 11 age-matched control participants underwent examinations at baseline and after 5 years. Visual acuity, contrast sensitivity, reading acuity, frequency doubling perimetry, Humphrey field analyzer, and dark adaptation were measured. The Low Luminance Questionnaire and National Eye Institute Vision Function Questionnaire-25 were administered. Macular spectral-domain optical coherence tomography was taken.Results: After 5 years, patients who had previously undergone PRP for PDR (18.4 ± 7.9 years previously) showed significant deterioration in contrast sensitivity, reading acuity, frequency doubling perimetry 24-2 pattern standard deviation, and Humphrey field analyzer 10-2 foveal sensitivity, which were equivalent to age-related decreases in control participants. They revealed no further impairment in vision-related activities on questionnaires. In contrast with controls, their maculas showed pathologic disorganization of the retinal layers, especially the nerve fiber layer, which were thicker and constituted a greater proportion of the overall retinal thickness than the norm and associated with impaired vision. Conclusions:Patients with treated PDR had age-related decreases in vision, but stable quality of life. Prior injuries from the diabetes and, possibly, laser treatment led to substantial disruption in the retinal structure, which may explain the loss of vision.Translational Relevance: Despite PRP treatment, patients with regressed PDR had pathologic progression of the nerve fiber layer; further investigation may identify a new therapeutic target to reverse the visual deficits.

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Vision-targeted health related quality of life in older adults: patient-reported visibility problems in low luminance activities are more likely to decline than daytime activities

Cited by 25 publications

References 34 publications

SCORE2 Report 5: Vision-Related Function in Patients With Macular Edema Secondary to Central Retinal or Hemiretinal Vein Occlusion

SCORE2 Report 5: Vision-Related Function in Patients With Macular Edema Secondary to Central Retinal or Hemiretinal Vein Occlusion

Association of Low Luminance Questionnaire With Objective Functional Measures in Early and Intermediate Age-Related Macular Degeneration

Treated PDR Reveals Age-Appropriate Vision Deterioration But Distorted Retinal Organization

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