Vision-Related Quality of Life in Patients with Infectious Keratitis

Li, Yimin; Hong, Jiaxu; Wei, Anji; Wang, Xin; Chen, Yan; Cui, Xinhan; Sun, Xinghuai; Liu, Zuguo; Xu, Jianjiang

doi:10.1097/opx.0000000000000156

Cited by 20 publications

(21 citation statements)

References 22 publications

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“…Many papers report measuring VA with a Snellen chart and then analyse the data after converting it to logMAR . Snellen charts have an irregular progression in size and are often truncated, so that the data may not follow a normal distribution and parametric analyses might be best avoided .…”

Section: Confusion 1 Measuring With Snellen and Reporting Data As Lomentioning

confidence: 99%

The good (logMAR), the bad (Snellen) and the ugly (BCVA, number of letters read) of visual acuity measurement

Elliott

2016

Ophthalmic Physiologic Optic

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Section: Confusion 1 Measuring With Snellen and Reporting Data As Lomentioning

confidence: 99%

The good (logMAR), the bad (Snellen) and the ugly (BCVA, number of letters read) of visual acuity measurement

Elliott

2016

Ophthalmic Physiologic Optic

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“…The QOL in patients with ocular disorders can be affected by ocular symptoms, such as blurred vision, severe photophobia, or having difficulties in keeping eyes open due to discomfort. 12–14 Affected patients might not be able to drive, read, watch television, or perform other common activities in their routine daily life. In this study we describe the epidemiology of ocular GVHD symptoms in patients with chronic GVHD, perform a risk factor analyses, and describe the impact of ocular involvement on QOL.…”

Section: Introductionmentioning

confidence: 99%

Impact of Ocular Chronic Graft-versus-Host Disease on Quality of Life

Sun

Chai

Inamoto

et al. 2015

Biology of Blood and Marrow Transplantation

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Ocular involvement can be quite symptomatic in patients with chronic graft-versus-host disease (GVHD). The prevalence of and risk factors for ocular GVHD and its impact on quality of life (QOL) in patients with chronic GVHD were studied in a prospective, multicenter, longitudinal, observational study. This study enrolled 342 patients with 1,483 follow-up visits after allogeneic hematopoietic cell transplantation. All patients in this analysis were diagnosed with chronic GVHD requiring systemic treatment and enrolled within 3 months of chronic GVHD diagnosis. The symptom burden of ocular GVHD was based on the degree of dry eye symptoms, frequency of artificial tear usage, and impact on activities of daily living. Patients’ quality of life (QOL) was measured by self-administered questionnaires. Variables associated with ocular GVHD at enrollment and subsequent new onset ocular GVHD, and the associations with QOL were studied. Of the 284 chronic GVHD patients, 116 (41%) had ocular GVHD within 3 months of chronic GVHD diagnosis (“early ocular GVHD”). Late ocular GVHD (new onset > 3 months after chronic GVHD diagnosis) occurred in 64 patients. Overall cumulative incidence at 2 years was 57%. Female gender (p=0.005), higher acute GVHD grade (p=0.04) and higher prednisone dose at study entry (p=0.04) were associated with early ocular GVHD. For patients who did not have ocular GVHD within 3 months of chronic GVHD diagnosis, presence of prior grade I-IV acute GVHD (HR 1.78, P=0.04) was associated with shorter time to late ocular GVHD, while female donor into male recipient (HR 0.53, P=0.05) was associated with longer time to late ocular GVHD onset. Utilizing all visit data, patients with ocular GVHD had worse quality of life as measured by FACT-BMT (P=0.002), and greater chronic GVHD symptom burden, as measured by the Lee symptom overall score excluding the eye component (P<0.001) compared to patients who did not have ocular GVHD. In conclusion, this large multicenter, prospective study shows that ocular GVHD affects 57% of patients within 2 year of chronic GVHD diagnosis. Women, patients on higher doses of prednisone at study entry, and those with a history of acute GVHD were at higher risk for ocular GVHD. Strong evidence suggests that ocular GVHD is associated with worse overall health-related QOL.

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“…For example, a study of unilateral infectious keratitis found that vision-related quality of life was more correlated with vision in the worse-seeing eye. 18 Another study of patients with unilateral branch retinal vein occlusion found that visual acuity in the involved eye was most predictive of visual function. 19 A different study of unilateral central retinal vein occlusion (CRVO) found that although vision-related quality of life did not correlate with visual acuity in the affected eye, VFQ responses were lower than a reference group without eye disease—even among those patients with CRVO with excellent vision in the unaffected eye.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have suggested an increase in impact of visual disability in developing countries compared with developed countries. 318 …”

Section: Discussionmentioning

confidence: 99%

Risk factors for low vision related functioning in the Mycotic Ulcer Treatment Trial: a randomised trial comparing natamycin with voriconazole

et al. 2015

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Background/aims The Mycotic Ulcer Treatment Trial I (MUTT I) was a double-masked, multicentre, randomised controlled trial, which found that topical natamycin is superior to voriconazole for the treatment of filamentous fungal corneal ulcers. In this study, we determine risk factors for low vision-related quality of life in patients with fungal keratitis. Methods The Indian visual function questionnaire (IND-VFQ) was administered to MUTT I study participants at 3 months. Associations between patient and ulcer characteristics and IND-VFQ subscale score were assessed using generalised estimating equations. Results 323 patients were enrolled in the trial, and 292 (90.4%) completed the IND-VFQ at 3 months. Out of a total possible score of 100, the average VFQ score for all participants was 81.3 (range 0–100, SD 23.6). After correcting for treatment arm, each logMAR line of worse baseline visual acuity in the affected eye resulted in an average 1.2 points decrease on VFQ at 3 months (95% CI −1.8 to 0.6, p<0.001). Those who required therapeutic penetrating keratoplasty had an average of 25.2 points decrease on VFQ after correcting for treatment arm (95% CI −31.8 to −18.5, p<0.001). Study participants who were unemployed had on average 28.5 points decrease on VFQ (95% CI −46.9 to −10.2, p=0.002) after correcting for treatment arm. Conclusions Monocular vision loss from corneal opacity due to fungal keratitis reduced vision-related quality of life. Given the relatively high worldwide burden of corneal opacity, improving treatment outcomes of corneal infections should be a public health priority. Trial registration number Clinicaltrials.gov Identifier: NCT00996736.

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Vision-Related Quality of Life in Patients with Infectious Keratitis

Cited by 20 publications

References 22 publications

The good (logMAR), the bad (Snellen) and the ugly (BCVA, number of letters read) of visual acuity measurement

The good (logMAR), the bad (Snellen) and the ugly (BCVA, number of letters read) of visual acuity measurement

Impact of Ocular Chronic Graft-versus-Host Disease on Quality of Life

Risk factors for low vision related functioning in the Mycotic Ulcer Treatment Trial: a randomised trial comparing natamycin with voriconazole

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