Vision-Related Quality of Life and Visual Function After Retinal Detachment Surgery

Smretschnig, Eva; Falkner-Radler, Christiane I.; Binder, Susanne; Spörl, Jessica; Ristl, Robin; Glittenberg, Carl; Krepler, Katharina

doi:10.1097/iae.0000000000000817

Cited by 25 publications

(19 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most clinical studies use BCVA as the single visual outcome measure because it is considered to be the major determinant of vision-related quality of life. 23 However, the current study supports the idea that merely measuring BCVA inadequately evaluates vision-related quality of life and visual function in patients after surgery for macula-off RRD. This idea is also supported by Lina et al, 7 who investigated three visual function parameters (BCVA, stereopsis and metamorphopsia) and found that vision-related quality of life correlated with metamorphopsia, but not with BCVA.…”

Section: Discussionsupporting

confidence: 60%

Visual Acuity Inadequately Reflects Vision-Related Quality of Life in Patients After Macula-Off Retinal Detachment Surgery

Vermeer

Meurs

et al. 2020

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

To determine the impact of postoperative visual function on the vision-related quality of life (VRQoL) in patients after anatomically successful surgery for macula-off rhegmatogenous retinal detachment (RRD) and to propose a classification to grade the extent of macular detachment using preoperative optical coherence tomography (OCT) scans. METHODS. This prospective study evaluated 48 patients. At 12 months after surgery, visual function assessments were as follows: metamorphopsia (M-CHARTS), aniseikonia (New Aniseikonia Test), best corrected visual acuity (BCVA) (Early Treatment Diabetic Retinopathy Study [ETDRS]), low contrast BCVA (10% ETDRS), color vision (Hardy Rand Rittler), and stereopsis (Titmus Fly). VRQoL was assessed by the National Eye Institute Visual Functioning Questionnaire-25 (NEIVFQ-25). Associations between visual function parameters and NEIVFQ-25 scores were evaluated. Preoperative OCT-scans were classified into six stages according to the extent of macular detachment based on an ETDRS-grid: incomplete perifoveal detachment (1), incomplete parafoveal detachment (2), incomplete foveal detachment (3), complete foveal detachment (4), complete parafoveal detachment (5), and complete perifoveal detachment (6). RESULTS. General vision and driving were the lowest scoring categories. General vision had the strongest correlation with low contrast BCVA (r = −0.41, P = 0.002), while driving had the strongest correlation with stereopsis (r = −0.39, P = 0.008). All macular detachments were graded stage 3 or beyond. Patients with stage 3 macular detachments had the highest visual function values compared to the other stages. The highest percentage of patients with metamorphopsia, aniseikonia and BCVA>0.1 logMAR was found in stages 5 and 6. CONCLUSIONS. Macula-off RRD particularly affects general vision and driving. The extent of macular detachment is a potential predictor for visual function and can be graded using the proposed classification.

show abstract

Section: Discussionsupporting

confidence: 60%

Visual Acuity Inadequately Reflects Vision-Related Quality of Life in Patients After Macula-Off Retinal Detachment Surgery

Vermeer

Meurs

et al. 2020

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…Studies determining the vision-related quality of life in people with ocular chemical injury revealed that ocular chemical burns have a significant and negative impact on a broad array of vision-related quality of life: visual acuity, physical function, and social function 5 . The quality of life of patients with chemical burns was also found to be significantly lower than that reported in other ocular diseases 6 . Ocular pain is very common in those patients and has significantly long-lasting effects on the patient's quality of life.…”

Section: Introductionmentioning

confidence: 52%

Alkali Burn Induced Corneal Spontaneous Pain and Activated Neuropathic Pain Matrix in the Central Nervous System in Mice

Xiang

Zhou

Wang

et al. 2017

Cornea

View full text Add to dashboard Cite

show abstract

“…Retinal detachment (RD), the separation of the neural retina from the underlying retinal pigment epithelium (RPE), is a well-known cause of visual loss and has a major impact on quality of life 1 . Although the retina can be reattached by various surgical procedures, the final visual outcome is often unsatisfactory [2][3][4][5][6][7][8] .…”

mentioning

confidence: 99%

ROCK inhibition reduces morphological and functional damage to rod synapses after retinal injury

Halasz

Zarbin

Davidow

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Retinal detachment (RD) causes damage, including disjunction, of the rod photoreceptor-bipolar synapse, which disrupts vision and may contribute to the poor visual recovery observed after retinal reattachment surgery. We created a model of iatrogenic RD in adult female pigs to study damage to the rod-bipolar synapse after injury and the ability of a highly specific Rho-kinase (ROCK) inhibitor to preserve synaptic structure and function. This model mimics procedures used in humans when viral vectors or cells are injected subretinally for treatment of retinal disease. Synaptic disjunction by retraction of rod spherules, quantified by image analysis of confocal sections, was present 2 h after detachment and remained 2 days later even though the retina had spontaneously reattached by then. Moreover, spherule retraction occurred in attached retina 1–2 cms from detached retina. Synaptic damage was significantly reduced by ROCK inhibition in detached retina whether injected subretinally or intravitreally. Dark-adapted full-field electroretinograms were recorded in reattached retinas to assess rod-specific function. Reduction in synaptic injury correlated with increases in rod-driven responses in drug-treated eyes. Thus, ROCK inhibition helps prevent synaptic damage and improves functional outcomes after retinal injury and may be a useful adjunctive treatment in iatrogenic RD and other retinal degenerative diseases.

show abstract

Vision-Related Quality of Life and Visual Function After Retinal Detachment Surgery

Abstract: The vision-related quality of life is significantly impaired in patients after surgery for RRD. Higher age and female gender negatively influences the results of the composite score.

Cited by 25 publications

References 27 publications

Visual Acuity Inadequately Reflects Vision-Related Quality of Life in Patients After Macula-Off Retinal Detachment Surgery

Visual Acuity Inadequately Reflects Vision-Related Quality of Life in Patients After Macula-Off Retinal Detachment Surgery

Alkali Burn Induced Corneal Spontaneous Pain and Activated Neuropathic Pain Matrix in the Central Nervous System in Mice

ROCK inhibition reduces morphological and functional damage to rod synapses after retinal injury

Contact Info

Product

Resources

About