Vision Loss in Optic Disc Drusen Correlates With Increased Macular Vessel Diameter and Flux and Reduced Peripapillary Vascular Density

Yan, Yan; Zhou, Xiao Hua; Chu, Zhongdi; Stell, Laurel; Shariati, Mohammad Ali; Wang, Ke; Liao, Yaping Joyce

doi:10.1016/j.ajo.2020.04.019

Cited by 16 publications

(26 citation statements)

References 33 publications

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“…As mentioned, OCTA is an emerging imaging technique that can be used to indirectly to capture functional changes in macular and peripapillary microvasculature, quantify vessel density, measure vessel length density, evaluate vascular tortuosity, and study vascular flow dynamics. [27][28][29][30][31] Previous OCTA studies have shown microvascular attenuation around the optic nerve head in ODD eyes. [27][28][29][30] Fard et al used OCTA to demonstrate a significant reduction in peripapillary vessel density in papilloedema and pseudo-papilloedema eyes (including cases of ODD) as compared with control eyes.…”

Section: The Role Of Octa In the Management Of Oddmentioning

confidence: 98%

“…[27][28][29][30][31] Previous OCTA studies have shown microvascular attenuation around the optic nerve head in ODD eyes. [27][28][29][30] Fard et al used OCTA to demonstrate a significant reduction in peripapillary vessel density in papilloedema and pseudo-papilloedema eyes (including cases of ODD) as compared with control eyes. 32 Interestingly, these investigators reported no difference in peripapillary vascular density between eyes with papilloedema versus pseudo-papilloedema.…”

Section: The Role Of Octa In the Management Of Oddmentioning

confidence: 98%

“…33 In related work, Cennamo et al 27 evaluated 13 ODD patients with OCTA and reported lower flow indices and peripapillary vessel density measures in ODD eyes relative to normal eyes. Finally, Yan et al 30 compared OCTA and static perimetry findings between 17 patients with ODD (29 eyes) and 35 control subjects (53 eyes). In this study, ODD eyes had significantly worse visual field mean deviation, lower RNFL thickness values, and decreased peripapillary vascular density measures compared with controls.…”

Section: Prior To Scanningmentioning

confidence: 99%

“…In this study, ODD eyes had significantly worse visual field mean deviation, lower RNFL thickness values, and decreased peripapillary vascular density measures compared with controls. 30 These investigators described five key measurements that best correlated with visual field loss including: thinning of the peripapillary RNFL; reduced ganglion cell inner plexiform layer (GCIPL) thickness; decreased peripapillary vessel area density; increased macular vessel diameter; and increased macular flux (defined as the number of blood cells passing through a retinal vessel cross-sectional area over time). 30 The relative increase in macular vessel diameter and flux were novel findings, and were noted to occur in ODD cases with mild visual field loss and relative preservation of neuroaxonal integrity.…”

Section: Prior To Scanningmentioning

confidence: 99%

“…30 These investigators described five key measurements that best correlated with visual field loss including: thinning of the peripapillary RNFL; reduced ganglion cell inner plexiform layer (GCIPL) thickness; decreased peripapillary vessel area density; increased macular vessel diameter; and increased macular flux (defined as the number of blood cells passing through a retinal vessel cross-sectional area over time). 30 The relative increase in macular vessel diameter and flux were novel findings, and were noted to occur in ODD cases with mild visual field loss and relative preservation of neuroaxonal integrity. 30 The authors suggested that early increases in macular vessel diameter and flux may represent autoregulatory changes in retinal microvasculature.…”

Section: Prior To Scanningmentioning

confidence: 99%

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Diagnosing Optic Disc Drusen in the Modern Imaging Era: A Practical Approach

Costello

Rothenbuehler

et al. 2020

Neuro-Ophthalmology

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Optic disc drusen (ODD) are a well-recognised cause of an elevated optic disc appearance. When visible with ophthalmoscopy and fundus photography, ODD are readily identified. Yet, in more subtle cases of ODD, ancillary testing may be needed to render the diagnosis. Facilitating the diagnosis of ODD has clinical relevance, because affected individuals may otherwise undergo unnecessary costly and invasive investigations to rule out raised intracranial pressure and other causes of optic disc oedema. In this review, the role of established and emerging optical coherence tomography (OCT) techniques in the diagnosis and management of ODD cases is reviewed. A practical approach is taken to explain how to optimise use of commercially available OCT technology in the clinical setting. Optical coherence tomography provides many advantages over other imaging modalities in the diagnosis of ODD, including the ability to correlate retinal measures of neuroaxonal structure with drusen characteristics. Earlier spectral domain OCT techniques, however, were hindered by poor penetrance. In the modern imaging era, enhanced depth imaging OCT and swept source OCT enable higher resolution of ODD and other optic nerve head structures that might otherwise be mistaken for drusen. Ongoing studies featuring OCT angiography indicate that this technique may provide complementary information about microvascular supply that correlate with structural measures of optic nerve injury. Advances in OCT will continue to improve diagnostic accuracy and inform clinical understanding regarding structure-function correlations germane to the longitudinal follow up of ODD patients.

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Section: The Role Of Octa In the Management Of Oddmentioning

confidence: 98%

Section: The Role Of Octa In the Management Of Oddmentioning

confidence: 98%

Section: Prior To Scanningmentioning

confidence: 99%

Section: Prior To Scanningmentioning

confidence: 99%

Section: Prior To Scanningmentioning

confidence: 99%

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Diagnosing Optic Disc Drusen in the Modern Imaging Era: A Practical Approach

Costello

Rothenbuehler

et al. 2020

Neuro-Ophthalmology

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Dimension‐based quantification of aging‐associated cerebral microvasculature determined by optical coherence tomography and two‐photon microscopy

Yan,

Alhajeri,

Nyul‐Toth

et al. 2024

Journal of Biophotonics

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Cerebral microvascular health is a key biomarker for the study of natural aging and associated neurological diseases. Our aim is to quantify aging‐associated change of microvasculature at diverse dimensions in mice brain. We used optical coherence tomography (OCT) and two‐photon microscopy (TPM) to obtain nonaged and aged C57BL/6J mice cerebral microvascular images in vivo. Our results indicated that artery & vein, arteriole & venule, and capillary from nonaged and aged mice showed significant differences in density, diameter, complexity, perimeter, and tortuosity. OCT angiography and TPM provided the comprehensive quantification for arteriole and venule via compensating the limitation of each modality alone. We further demonstrated that arteriole and venule at specific dimensions exhibited negative correlations in most quantification analyses between nonaged and aged mice, which indicated that TPM and OCT were able to offer complementary vascular information to study the change of cerebral blood vessels in aging.

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