Vision 20/20: The role of Raman spectroscopy in early stage cancer detection and feasibility for application in radiation therapy response assessment

Devpura, Suneetha; Barton, Kenneth; Brown, Stephen L.; Palyvoda, Olena; Kalkanis, Steven N.; Naik, V. M.; Siddiqui, Farzan; Naik, R.; Chetty, Indrin J.

doi:10.1118/1.4870981

Cited by 44 publications

(43 citation statements)

References 97 publications

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“…This technique has been used to investigate radiation damage to plasma membranes of Chinese hamster cells, 1 and detect radiation-induced chemical and structural changes in DNA of mouse breast cancer cells. 2 Lakshmi et al 3 irradiated the heads of mice, observing changes in Raman spectra not only for brain tissue, but also for leg muscle tissue. Harder et al 4 pointed out the potential of RS for assessing radiosensitivity, demonstrating changes in glycogen accumulation (potentially indicative of hypoxic recovery) in nonsmall cell lung cancer (NSCLC) cells in response to 6 MV photon irradiation.…”

Section: Introductionmentioning

confidence: 99%

Microdosimetric considerations for radiation response studies using Raman spectroscopy

Oliver

Thomson

2018

Medical Physics

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Section: Introductionmentioning

confidence: 99%

Microdosimetric considerations for radiation response studies using Raman spectroscopy

Oliver

Thomson

2018

Medical Physics

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“…Spectroscopy is even less studied although its feasibility has been demonstrated in head and neck tumors. However, diagnostic accuracy remains speculative currently [10]. …”

Section: Discussionmentioning

confidence: 99%

“…Next, perfusion and magnetic resonance spectroscopy (MRS) are promising techniques [9,10]. This is further supported by a recent overview [11].…”

Section: Introductionmentioning

confidence: 94%

Diagnostic accuracy of magnetic resonance imaging techniques for treatment response evaluation in patients with head and neck tumors, a systematic review and meta-analysis

et al. 2017

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BackgroundNovel advanced MRI techniques are investigated in patients treated for head and neck tumors as conventional anatomical MRI is unreliable to differentiate tumor from treatment related imaging changes.PurposeAs the diagnostic accuracy of MRI techniques to detect tumor residual or recurrence during or after treatment is variable reported in the literature, we performed a systematic meta-analysis.Data sourcesPubmed, EMBASE and Web of Science were searched from their first record to September 23th 2014.Study selectionStudies reporting diagnostic accuracy of anatomical, ADC, perfusion or spectroscopy to identify tumor response confirmed by histology or follow-up in treated patients for head and neck tumors were selected by two authors independently.Data analysisTwo authors independently performed data extraction including true positives, false positives, true negatives, false negatives and general study characteristics. Meta-analysis was performed using bivariate random effect models when ≥5 studies per test were included.Data synthesisWe identified 16 relevant studies with anatomical MRI and ADC. No perfusion or spectroscopy studies were identified. Pooled analysis of anatomical MRI of the primary site (11 studies, N = 854) displayed a sensitivity of 84% (95%CI 72–92) and specificity of 82% (71–89). ADC of the primary site (6 studies, N = 287) showed a pooled sensitivity of 89% (74–96) and specificity of 86% (69–94).LimitationsMain limitation are the low, but comparable quality of the included studies and the variability between the studies.ConclusionsThe higher diagnostic accuracy of ADC values over anatomical MRI for the primary tumor location emphases the relevance to include DWI with ADC for response evaluation of treated head and neck tumor patients.

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“…(ii) Electromagnetic field emitted or scattered by molecules located in close proximity can be used in areas such as chemical and material science art restorations, military, plasmonics nanoparticles, the existence of cancerous and healthy cells, infections and hereditary diseases [8][9][10][11][12][13][14][15].…”

Section: Eejp 4 (2019)mentioning

confidence: 99%

Effect of the Oscillating Electric Field Due to the Oscillating Electric Dipole on Raman Lines

Kapil

Gilbert

2019

EEJP

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Raman Effect is the measurement of the intensity and wavelength of the inelastically scattered radiation that falls on a molecule. The electric field of the incident radiation polarizes the molecule on which it falls and this leads to the creation of an oscillating dipole. The incident polarized laser light is inelastically scattered by the molecular sample. The scattered light contains modified wavelengths called the Stokes and anti-Stokes lines or wavelengths. The oscillating electric dipole, created by the incident radiation, creates an oscillating electric field around it. Since the oscillating electric field of the incident radiation creates an oscillating electric dipole that create an oscillating electric field around it, it was surmised that this oscillating electric field can affect the frequency of vibration or oscillation of the oscillating electric dipole that produces it. This novel effect will change the frequency (frequencies) of the scattered radiation resulting in Stokes and anti-Stokes lines with modified frequencies. This theoretical research and its importance can be understood like this. For instance, if there are two cells or molecules, side by side, in which one is a healthy cell and the other is cancerous, or two different types of molecules are sitting side by side, this types of scattering should be able to distinguish one from the other since the Stokes and anti-Stokes lines from the two molecules will not be identical. Thus, the incident radiation of angular frequency ω1 polarizes the charges of the molecule on which it falls and this leads to the creation of an oscillating dipole of frequency ω2. The oscillating dipole creates an oscillating electric field that can create additional frequency of the oscillating dipole that created it, and let this be ωD. Then the Raman lines can have frequencies (ω1+ω2+ωD), (ω1+ω2-ωD), (ω1-ω2+ωD), and (ω1-ω2-ωD). Depending on the relative magnitudes of ω2 and ωD, Raman lines will be designated as Stokes and Anti-Stokes lines. Due to the law of conservation of energy, ωD will be less than ω2 since an oscillating dipole cannot create field of frequency more than its own frequency. Hence the frequencies (ω1-ω2+ωD) and (ω1-ω2-ωD) correspond to Stokes lines, and frequencies. (ω1+ω2+ωD) and (ω1+ω2‑ωD) will correspond to Anti-Stokes lines. Calculations for Stokes and Anti-stokes lines have been done for some molecules, namely Ammonia compound (NH3), Nitrousoxide compound (N2O), Water (H2O), Sulphur dioxide compound (SO2), Ozone compound (O3). Calculations have also been done for compounds containing carbon, such as Dichloromethane compound (CH4Cl2), Formic acid compound (CH2O2), Methanol compound (CH4O), Benzene compound (C6H6), Propane compound (C3H8), and Carbonyl chloride compound (Cl2CO). The theory developed predicts new phenomena of getting Stokes and anti-Stokes lines with modified wavelengths which have not been observed experimentally as of to-day.

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Vision 20/20: The role of Raman spectroscopy in early stage cancer detection and feasibility for application in radiation therapy response assessment

Cited by 44 publications

References 97 publications

Microdosimetric considerations for radiation response studies using Raman spectroscopy

Microdosimetric considerations for radiation response studies using Raman spectroscopy

Diagnostic accuracy of magnetic resonance imaging techniques for treatment response evaluation in patients with head and neck tumors, a systematic review and meta-analysis

Effect of the Oscillating Electric Field Due to the Oscillating Electric Dipole on Raman Lines

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