Visible-Light-Promoted Iron(II)/Lewis Base Catalysis for the Alkylation of Morita–Baylis–Hillman Acetates Using Carboxylic Acids
Durga Golagani,
Kota Krishna Prakash,
Satyam Thapa
et al.
Abstract:A novel photoinduced Fe(OTf)2/2,4,6-collidine-catalyzed
alkylation of Morita–Baylis–Hillman (MBH) acetates using
carboxylic acids in a regio- and stereoselective manner is reported.
This method demonstrates a broad scope, encompassing various carboxylic
acids and MBH acetates, including drugs and bioactive molecules, to
synthesize densely functionalized cinnamates and acrylates. The reactions
are performed in the green solvent dimethyl carbonate under oxidant-free
conditions. Based on control experiments, a pl… Show more
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