Visible‐Light‐Promoted Difluoromethylation/Cyclization of 1‐Acryloyl‐2‐cyanoindole for Construction of Difluoromethylated Pyrrolo[1,2‐a]indolediones
Hongzhao Qu,
Jinwei Yuan,
Zhendong Feng
et al.
Abstract:A simple and convenient visible‐light‐promoted cascade difluoromethylation/cyclization reaction to access various difluoromethylated pyrrolo[1,2‐<i>a</i>]indolediones was developed using difluoromethyltriphenylphosphonium bromide salt as the difluoromethylated reagent under mild conditions. The methodology features a wide substrate scope, good functional group tolerance, good to excellent yields, and mild reaction conditions. A possible radical mechanism has been investigated and proven as a single… Show more
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