Visible-light-mediated sulfonylation of anilines with sulfonyl fluorides
Xin-Qing Li,
Qian-Qian Liao,
Jun Lai
et al.
Abstract:Sulfonylaniline motif plays an important role in pharmaceutical sciences. Developed methods towards this structure are typically lack of good modifiability and stability. In this study, visible-light-mediated sulfonylation of aniline using sulfonyl fluoride as a modifiable and stable sulfonylation reagent is described. A variety of substituted sulfonylanilines were synthesized under mild reaction conditions with moderate to good efficiency. The example of late-stage sulfonylation highlighted the advantage of u… Show more
The site-selective sulfonylation of C(sp2)−H bonds of anilide and quinoline amide derivatives has been developed using organophotocatalysis. This mild and sustainable protocol, which operates at room temperature, precludes the requirement...
The site-selective sulfonylation of C(sp2)−H bonds of anilide and quinoline amide derivatives has been developed using organophotocatalysis. This mild and sustainable protocol, which operates at room temperature, precludes the requirement...
A number of β-iodovinyl sulfones were synthesized by direct difunctionalization of internal alkynes with arenesulfonyl iodides under irradiation with red light (λmax 625 nm) generated by an economical LED source. The products were obtained in high yields (68–99%) from equimolar amounts of the reactants. The reaction of sulfonyl iodides with internal alkynes follows a radical mechanism and provides a regioselective method of synthesis of β-iodovinyl sulfones.
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