Visible-Light-Mediated gem-Difunctionalization of Diazo Compounds with Vinyl Sulfoxonium Ylides and Thiols
Janakiram Vaitla,
Srashti Bhardwaj,
Raju Sen
et al.
Abstract:Herein, a visible-light-induced multicomponent reaction of vinyl sulfoxonium ylide, thiol, and diazo ester is described for the synthesis of a tertiary sulfide. The present diastereoselective gem-difunctionalization of the diazo ester can be achieved under mild conditions, as it does not require any additives, catalysts, or transition metals and is tolerant of air and moisture. Due to more nucleophilicity, vinyl sulfoxonium ylide undergoes S-H insertion with thiols to generate an allyl sulfide intermediate. Si… Show more
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