Visible light-mediated copper catalyzed regioselective diamination of terminal alkynes at room temperature: a facile synthesis of substituted imidazo[1,2-α]pyridines

Abstract

We have developed a visible-light mediated copper(I) chloride catalyzed regioselective oxidative diamination reaction of 2-aminopyridines with terminal alkynes to form substituted imidazo[1,2-]pyridines products at room temperature using molecular oxygen as...

Efficient synthesis of bioactive isoindolinone derivatives containing continuous quaternary carbons by intermolecular OH transfer

“…The green chemistry metric evaluation for the current green process has an E -factor of 5.70, 93.5% atom economy, 81.1% atom efficiency, 100% carbon efficiency and 67.3% reaction mass efficiency (Table 3). The Eco-Scale value 28,29 for the current green process was calculated and is listed in Table 4. The evaluated Eco-Scale value is 68.35, which indicates that the current synthetic reaction is safe, eco-friendly and highly efficient.…”

γ-Hydroxy-γ-butyrolactams as 1,2-bis-electrophiles in a Brønsted/Lewis acid-free synthesis of condensed nitrogen heterocycles

“…During the reaction with 2-aminopyridines 9 , in contrast, lactams 1 act as analogues of phenacyl bromides, which is accompanied by elimination of a small HNCO fragment. It is worth noting that the related one-pot reaction of 2-aminopyridines 9 with arylglyoxals and 1,3-dicarbonyl compounds described previously, 49 but among those presented in the literature, 50–53 the most common method is based on the reaction with α-halogenketones. 54–57…”