Visible‐Light‐Induced N‐Heterocyclic Carbene‐Catalyzed Single Electron Reduction of Mono‐Fluoroarenes

Abstract

Fluoroarenes are abundant and readily available feedstocks. However, due to the high reduction potentials of mono-fluoroarenes, their photoreduction remains a continuing challenge, motivating the development of efficient activation modes to address this issue. This report presents the blue light-induced N-heterocyclic carbene (NHC)-catalyzed single electron reduction of mono-fluoroarenes for biaryl cross-couplings. We discovered that under blue light irradiation, NHC/ tBuOK combination could construct powerful photoactive architectures to promote single electron transfer for C aryl À F bond reduction via forming highly reducing NHC radical anion. Notably, the strategy was also successful to reduce C aryl À O, C aryl À N, and C aryl À S bonds for biaryl cross-couplings.