Visible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy

Zhai, Shaodong; Hu, Xianglong; Hu, Yongjun; Wu, Baoyan

doi:10.1016/j.biomaterials.2017.01.002

Cited by 193 publications

(115 citation statements)

References 90 publications

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“…Further studies were done to evaluate the catalysis capacity of Au@Rh‐CM under a pathophysiologically relevant concentration (1 × 10 −4 m ). [ 42 ] To better understand the O 2 generation kinetics of Au@Rh‐CM‐enabled H 2 O 2 decomposition, an O 2 probe of [Ru(dpp) 3 ]Cl 2 (RDPP), whose fluorescence can be immediately quenched by O 2 , [ 43 ] was used to monitor O 2 generation. As shown in Figure a, addition of H 2 O 2 (1 × 10 −4 m ) to the Au@Rh‐CM/RDPP aqueous solution caused immediate decrease of fluorescence intensity of RDPP for the first 10 min.…”

Section: Methodsmentioning

confidence: 99%

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H₂O₂‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

et al. 2020

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In treatment of hypoxic tumors, oxygen‐dependent photodynamic therapy (PDT) is considerably limited. Herein, a new bimetallic and biphasic Rh‐based core–shell nanosystem (Au@Rh‐ICG‐CM) is developed to address tumor hypoxia while achieving high PDT efficacy. Such porous Au@Rh core–shell nanostructures are expected to exhibit catalase‐like activity to efficiently catalyze oxygen generation from endogenous hydrogen peroxide in tumors. Coating Au@Rh nanostructures with tumor cell membrane (CM) enables tumor targeting via homologous binding. As a result of the large pores of Rh shells and the trapping ability of CM, the photosensitizer indocyanine green (ICG) is successfully loaded and retained in the cavity of Au@Rh‐CM. Au@Rh‐ICG‐CM shows good biocompatibility, high tumor accumulation, and superior fluorescence and photoacoustic imaging properties. Both in vitro and in vivo results demonstrate that Au@Rh‐ICG‐CM is able to effectively convert endogenous hydrogen peroxide into oxygen and then elevate the production of tumor‐toxic singlet oxygen to significantly enhance PDT. As noted, the mild photothermal effect of Au@Rh‐ICG‐CM also improves PDT efficacy. By integrating the superiorities of hypoxia regulation function, tumor accumulation capacity, bimodal imaging, and moderate photothermal effect into a single nanosystem, Au@Rh‐ICG‐CM can readily serve as a promising nanoplatform for enhanced cancer PDT.

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Section: Methodsmentioning

confidence: 99%

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H₂O₂‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

et al. 2020

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“…Besides the disulfide bond–involved DDSs that can respond to GSH in tumor and cytosol, nanosystems containing diselenide group were also reported for the on‐demand drug release . Despite the acknowledged discrepancy in reduction sensitivity between GSH‐responsive diselenide bond and disulfide bond, but which one holding more sensitive responsiveness is still controversial.…”

Section: Positive Targetingmentioning

confidence: 99%

Recent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines

Qin

Zhang

2018

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105

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Efficacy and safety of chemotherapeutic drugs constitute two major criteria in tumor chemotherapy. Nanomedicines with tumor-targeted properties hold great promise for improving the efficacy and safety. To design targeted nanomedicines, the pathological characteristics of tumors are extensively and deeply excavated. Here, the rationale, principles, and advantages of exploiting these pathological characteristics to develop targeted nanoplatforms for tumor chemotherapy are discussed. Homotypic targeting with the ability of self-recognition to source tumors is reviewed individually. In the meanwhile, the limitations and perspective of these targeted nanomedicines are also discussed.

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“…When arriving at the target sites, the SCMs formed smart delivery systems and released drug rapidly by introducing stimulus-responsive groups into their polymers, which achieved high effective therapeutic effects [10][11][12][13][14][15][16]. In past years, with the advantages of stimulus-responsiveness, reversible chemical bonds, such as acetal, hydrazone, imine, diselenide bonds, disulfide, borate, and oxime bonds, are popular and have been used for smart drug delivery by several groups [17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

pH/Reduction Dual-Stimuli-Responsive Cross-Linked Micelles Based on Multi-Functional Amphiphilic Star Copolymer: Synthesis and Controlled Anti-Cancer Drug Release

et al. 2020

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Novel approach has been constructed for preparing the amphiphilic star copolymer pH/reduction stimuli-responsive cross-linked micelles (SCMs) as a smart drug delivery system for the well-controlled anti-tumor drug doxorubicin (DOX) release. The SCMs had a low CMC value of 5.3 mg/L. The blank and DOX-loaded SCMs both had a spherical shape with sizes around 100–180 nm. In addition, the good stability and well pH/reduction-sensitivity of the SCMs were determined by dynamic light scattering (DLS) as well. The SCMs owned a low release of DOX in bloodstream and normal tissues while it had a fast release in tumor higher glutathione (GSH) concentration and/or lower pH value conditions, which demonstrates their pH/reduction dual-responsiveness. Furthermore, we conducted the thermodynamic analysis to study the interactions between the DOX and polymer micelles in the DOX release process. The values of the thermodynamic parameters at pH 7.4 and at pH 5.0 conditions indicated that the DOX release was endothermic and controlled mainly by the forces of an electrostatic interaction. At pH 5.0 with 10 mM GSH condition, electrostatic interaction, chemical bond, and hydrophobic interactions contributed together on DOX release. With the low cytotoxicity of blank SCMs and well cytotoxicity of DOX-loaded SCMs, the results indicated that the SCMs could form a smart cancer microenvironment-responsive drug delivery system. The release kinetic and thermodynamic analysis offer a theoretical foundation for the interaction between drug molecules and polymer matrices, which helps provide a roadmap for the oriented design and control of anti-cancer drug release for cancer therapy.

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Visible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy

Cited by 193 publications

References 90 publications

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H₂O₂‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H₂O₂‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

Recent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines

pH/Reduction Dual-Stimuli-Responsive Cross-Linked Micelles Based on Multi-Functional Amphiphilic Star Copolymer: Synthesis and Controlled Anti-Cancer Drug Release

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Visible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy

Cited by 193 publications

References 90 publications

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H2O2‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H2O2‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

Recent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines

pH/Reduction Dual-Stimuli-Responsive Cross-Linked Micelles Based on Multi-Functional Amphiphilic Star Copolymer: Synthesis and Controlled Anti-Cancer Drug Release

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A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H₂O₂‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy

A Porous Au@Rh Bimetallic Core–Shell Nanostructure as an H₂O₂‐Driven Oxygenerator to Alleviate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy