Visible light enhances the antimicrobial effect of some essential oils

Marqués-Calvo, María Soledad; Codony, Francesc; Agustí, Gemma; Lahera, Carlos

doi:10.1016/j.pdpdt.2016.12.002

Cited by 15 publications

(12 citation statements)

References 30 publications

(31 reference statements)

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“…These extracts are currently used to inactivate the bacteria causing foodborne disease (Diao et al, 2013). In a study exploring the combination therapy of aBL with some essential oils, Marques-Calvo et al reported that aBL at 460–470 nm enhanced the antimicrobial activities of the clove and thyme oils against S. epidermidis , P. aeruginosa , and C. albicans (Marques-Calvo et al, 2016). In the study, essential oils were at 0.5% or 5% concentration.…”

Section: Synergism Of Antimicrobial Blue Light With Other Agentsmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

221

192

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As an innovative non-antibiotic approach, antimicrobial blue light in the spectrum of 400–470 nm has demonstrated its intrinsic antimicrobial properties resulting from the presence of endogenous photosensitizing chromophores in pathogenic microbes and, subsequently, its promise as a counteracter of antibiotic resistance. Since we published our last review of antimicrobial blue light in 2012, there have been a substantial number of new studies reported in this area. Here we provide an updated overview of the findings from the new studies over the past 5 years, including the efficacy of antimicrobial blue light inactivation of different microbes, its mechanism of action, synergism of antimicrobial blue light with other angents, its effect on host cells and tissues, the potential development of resistance to antimicrobial blue light by microbes, and a novel interstitial delivery approach of antimicrobial blue light. The potential new applications of antimicrobial blue light are also discussed.

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Section: Synergism Of Antimicrobial Blue Light With Other Agentsmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

221

192

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“…One study found that essential oils derived from eucalyptus (5%), clove (0.5%) and thyme (0.5%) improved the blue light (469–470 nm) inactivation of S. epidermidis and P. aeruginosa by 2–7 and 3–8 log CFU/mL, respectively, as compared with inactivation achieved by light alone. Relative to treatments with essential oils alone, samples treated with the combination of essential oils and blue light had 3–6 and 3–5 log CFU/mL lower counts of S. epidermidis and P. aeruginosa , respectively [ 238 ].…”

Section: Hurdle Technologymentioning

confidence: 99%

Antimicrobial Blue Light versus Pathogenic Bacteria: Mechanism, Application in the Food Industry, Hurdle Technologies and Potential Resistance

Hadi

Brightwell

2020

Foods

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Blue light primarily exhibits antimicrobial activity through the activation of endogenous photosensitizers, which leads to the formation of reactive oxygen species that attack components of bacterial cells. Current data show that blue light is innocuous on the skin, but may inflict photo-damage to the eyes. Laboratory measurements indicate that antimicrobial blue light has minimal effects on the sensorial and nutritional properties of foods, although future research using human panels is required to ascertain these findings. Food properties also affect the efficacy of antimicrobial blue light, with attenuation or enhancement of the bactericidal activity observed in the presence of absorptive materials (for example, proteins on meats) or photosensitizers (for example, riboflavin in milk), respectively. Blue light can also be coupled with other treatments, such as polyphenols, essential oils and organic acids. While complete resistance to blue light has not been reported, isolated evidence suggests that bacterial tolerance to blue light may occur over time, especially through gene mutations, although at a slower rate than antibiotic resistance. Future studies can aim at characterizing the amount and type of intracellular photosensitizers across bacterial species and at assessing the oxygen-independent mechanism of blue light—for example, the inactivation of spoilage bacteria in vacuum-packed meats.

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“…Several studies have shown that oral bacteria are sensitive to PDT in planktonic cultures. Recent studies have reported that PDT induced bacterial cell destruction and reduced bacterial counts by more than 10-fold in biofilms of Streptococcus mutants [ 22 , 23 , 24 , 25 , 26 ], Streptococcus sobrinus and Streptococcus sanguinis , using toluidine blue or erythrosine as a photosensitizer [ 2 , 27 , 28 ], silver nanoclusters/rose Bengal nanocomposite [ 22 ], curcumin and methylene blue [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…It was also desired to test the efficiency of photodynamic antimicrobial therapy on extracted teeth by scanning electron microscopy. As far as we know there is only one study that demonstrates the efficiency of photodynamic therapy using essential oils of eucalyptus ( Eucalyptus radiata ), clove ( Eugenia caryophyllata ) and thyme ( Thymus vulgaris ) on Staphylococcus epidermidis (CECT 231), Pseudomonas aeruginosa (CECT 110), and Candida albicans (1392) [ 25 ]. Marqués-Calvo et al [ 25 ] concluded that the photodynamic activity depends on the oil concentration and light source (red or blue light) and that phenols (eugenol and thymol) were the most potent antimicrobial agents, underlining that light exposure improved antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

“…As far as we know there is only one study that demonstrates the efficiency of photodynamic therapy using essential oils of eucalyptus ( Eucalyptus radiata ), clove ( Eugenia caryophyllata ) and thyme ( Thymus vulgaris ) on Staphylococcus epidermidis (CECT 231), Pseudomonas aeruginosa (CECT 110), and Candida albicans (1392) [ 25 ]. Marqués-Calvo et al [ 25 ] concluded that the photodynamic activity depends on the oil concentration and light source (red or blue light) and that phenols (eugenol and thymol) were the most potent antimicrobial agents, underlining that light exposure improved antimicrobial activity. Our study is the first study that approaches the investigation of essential oils (arnica oil from the sample containing curcuma, oregano, frankincense and Thieves blend) as photosensitizers for Escherichia coli and Staphylococcus aureus.…”

Section: Introductionmentioning

confidence: 99%

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Assessment and Characterization of Some New Photosensitizers for Antimicrobial Photodynamic Therapy (aPDT)

et al. 2020

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The novelty of this study consists on the formulation and evaluation of five complex experimental natural photosensitizers (PS): gel with oregano essential oil (O), gel with methylene blue (AM), gel with a mixture of essential oils (Thieves-H), gel with arnica oil and curcuma extract (CU) and gel with frankincense essential oil (T), used as photosensitizing agents (PS) in antimicrobial photodynamic therapy (aPDT) in the control of microbial biofilm in oral cavity. The experimental PS were characterized by gas chromatography-mass spectrometry (GC-MS), Fourier-transform infrared spectroscopy (FTIR), UV-Vis spectroscopy, cytotoxicity assay, antimicrobial effect and scanning electron microscopy (SEM). The IR spectra of the experimental PS with essential oils exhibit absorption bands due to the presence of water and glycerol in high quantities. The studied compounds had a reduced cytotoxic effect on cell cultures. The lowest cytotoxic effect was observed in experimental PS with oregano essential oil and methylene blue PS. Essential oils with proven antibacterial capabilities used in experimental PS confer antibacterial activity to the gels in which they are incorporated, an activity that may be more efficient use of a PDT therapy. Single bacteria were detected mainly by SEM after 12 h, while aggregate bacteria and micro colonies dominated the samples at 48 h.

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Visible light enhances the antimicrobial effect of some essential oils

Cited by 15 publications

References 30 publications

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Antimicrobial Blue Light versus Pathogenic Bacteria: Mechanism, Application in the Food Industry, Hurdle Technologies and Potential Resistance

Assessment and Characterization of Some New Photosensitizers for Antimicrobial Photodynamic Therapy (aPDT)

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