Visible-Light Driven Enantioselective Radical Addition to Imines Ena-bled by Excitation of Chiral Phosphoric Acid–Imine Complex

Abstract

A visible-light driven enantioselective radical addition to imines enabled by the direct excitation of a chiral phosphoric acid-imine complex was developed. By using benzothiazolines as the radical precursors, chiral amine products were obtained with high enantioselectivities (up to 98% ee). Mechanistic studies elucidated that the chiral phosphoric acid-imine complex has photoredox activities for oxidizing benzothiazolines.