Visibility of mammographically occult breast cancer on diffusion-weighted MRI versus ultrasound

Amornsiripanitch, Nita; Rahbar, Habib; Kitsch, Averi E.; Lam, Diana L.; Weitzel, Brett; Partridge, Savannah C.

doi:10.1016/j.clinimag.2017.10.017

Cited by 18 publications

(9 citation statements)

References 50 publications

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“…In a study involving 118 mammographically occult lesions (91 benign, 27 malignant), DW MRI could detect 89% of the DCE MRI-detected malignancies, when the readers were not blinded to the images from DCE MRI (56). In another nonblinded study involving 60 mammographically occult cancers, DW MRI detected more cancers, compared to the MRI-guided focused ultrasound (78% and 63%, respectively, p = 0.049) (77). In previous blinded reader studies in which the readers assessed only unenhanced MRI sequences, including DW MRI with or without nonenhanced T1/T2weighted image, the sensitivity of DW MRI in various study designs ranged from 45% to 94% (27,34,49,50,78,79).…”

Section: Unenhanced Mri For Breast Cancer Screeningmentioning

confidence: 96%

Diffusion-Weighted Magnetic Resonance Imaging of the Breast: Standardization of Image Acquisition and Interpretation

2021

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Diffusion-weighted (DW) magnetic resonance imaging (MRI) is a rapid, unenhanced imaging technique that measures the motion of water molecules within tissues and provides information regarding the cell density and tissue microstructure. DW MRI has demonstrated the potential to improve the specificity of breast MRI, facilitate the evaluation of tumor response to neoadjuvant chemotherapy and can be employed in unenhanced MRI screening. However, standardization of the acquisition and interpretation of DW MRI is challenging. Recently, the European Society of Breast Radiology issued a consensus statement, which described the acquisition parameters and interpretation of DW MRI. The current article describes the basic principles, standardized acquisition protocols and interpretation guidelines, and the clinical applications of DW MRI in breast imaging.

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Section: Unenhanced Mri For Breast Cancer Screeningmentioning

confidence: 96%

Diffusion-Weighted Magnetic Resonance Imaging of the Breast: Standardization of Image Acquisition and Interpretation

2021

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“…Greater visibility of mammographically occult breast cancer on DWI compared to ultrasound was shown by Amornsiripanitch et al. ( 14 ). Compared to DCE-MRI, Pinker et al.…”

Section: Clinical Applicationsmentioning

confidence: 83%

“…Superior performance of DWI in the evaluation of mammographically occult and non-palpable breast cancers, particularly in women with dense breasts, compared to mammography alone has been reported (12,13). Greater visibility of mammographically occult breast cancer on DWI compared to ultrasound was shown by Amornsiripanitch et al (14). Compared to DCE-MRI, Pinker et al showed that current DWI as a standalone tool demonstrates inferior sensitivity and diagnostic performance (15).…”

Section: Clinical Applications Screeningmentioning

confidence: 99%

Diffusion Breast MRI: Current Standard and Emerging Techniques

et al. 2022

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The role of diffusion weighted imaging (DWI) as a biomarker has been the subject of active investigation in the field of breast radiology. By quantifying the random motion of water within a voxel of tissue, DWI provides indirect metrics that reveal cellularity and architectural features. Studies show that data obtained from DWI may provide information related to the characterization, prognosis, and treatment response of breast cancer. The incorporation of DWI in breast imaging demonstrates its potential to serve as a non-invasive tool to help guide diagnosis and treatment. In this review, current technical literature of diffusion-weighted breast imaging will be discussed, in addition to clinical applications, advanced techniques, and emerging use in the field of radiomics.

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“…The literature suggests that lesions with sizes less than 1 cm and DCIS manifesting as calcifications may be more difficult to detect on DW MRI [ 16 23 24 25 30 ]. The lower detection rate for smaller cancers (≤ 0.5 cm) in our study was expected, given that our DW MRI axial in-plane spatial resolution (1.9 × 1.9 mm 2 ) and section thickness (3 mm) could result in a partial volume effect for small lesions.…”

Section: Discussionmentioning

confidence: 99%

“…There is emerging evidence that DW MRI can be part of a multiparametric or non-contrast-enhanced approach for local staging of the affected breast in women with breast cancer [ 21 22 ]. In detecting clinically occult breast cancer, the sensitivity of DW MRI is lower than that of DCE MRI, but probably higher than that of mammography or targeted US [ 23 24 25 26 ]. However, the performance of DW MRI, relative to that of combined mammography and whole-breast US, in the detection of clinically occult breast cancer is unknown [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Contralateral Breast Cancer Using Diffusion-Weighted Magnetic Resonance Imaging in Women with Newly Diagnosed Breast Cancer: Comparison with Combined Mammography and Whole-Breast Ultrasound

Chang

Lee

et al. 2021

Korean J Radiol

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Objective To compare the screening performance of diffusion-weighted (DW) MRI and combined mammography and ultrasound (US) in detecting clinically occult contralateral breast cancer in women with newly diagnosed breast cancer. Materials and Methods Between January 2017 and July 2018, 1148 women (mean age ± standard deviation, 53.2 ± 10.8 years) with unilateral breast cancer and no clinical abnormalities in the contralateral breast underwent 3T MRI, digital mammography, and radiologist-performed whole-breast US. In this retrospective study, three radiologists independently and blindly reviewed all DW MR images (b = 1000 s/mm 2 and apparent diffusion coefficient map) of the contralateral breast and assigned a Breast Imaging Reporting and Data System category. For combined mammography and US evaluation, prospectively assessed results were used. Using histopathology or 1-year follow-up as the reference standard, cancer detection rate and the patient percentage with cancers detected among all women recommended for tissue diagnosis (positive predictive value; PPV 2 ) were compared. Results Of the 30 cases of clinically occult contralateral cancers (13 invasive and 17 ductal carcinoma in situ [DCIS]), DW MRI detected 23 (76.7%) cases (11 invasive and 12 DCIS), whereas combined mammography and US detected 12 (40.0%, five invasive and seven DCIS) cases. All cancers detected by combined mammography and US, except two DCIS cases, were detected by DW MRI. The cancer detection rate of DW MRI (2.0%; 95% confidence interval [CI]: 1.3%, 3.0%) was higher than that of combined mammography and US (1.0%; 95% CI: 0.5%, 1.8%; p = 0.009). DW MRI showed higher PPV 2 (42.1%; 95% CI: 26.3%, 59.2%) than combined mammography and US (18.5%; 95% CI: 9.9%, 30.0%; p = 0.001). Conclusion In women with newly diagnosed breast cancer, DW MRI detected significantly more contralateral breast cancers with fewer biopsy recommendations than combined mammography and US.

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Visibility of mammographically occult breast cancer on diffusion-weighted MRI versus ultrasound

Abstract: DWI may detect more mammographically occult cancers than ultrasound, warranting further investigation as an alternative supplemental screening technique.

Cited by 18 publications

References 50 publications

Diffusion-Weighted Magnetic Resonance Imaging of the Breast: Standardization of Image Acquisition and Interpretation

Diffusion-Weighted Magnetic Resonance Imaging of the Breast: Standardization of Image Acquisition and Interpretation

Diffusion Breast MRI: Current Standard and Emerging Techniques

Detection of Contralateral Breast Cancer Using Diffusion-Weighted Magnetic Resonance Imaging in Women with Newly Diagnosed Breast Cancer: Comparison with Combined Mammography and Whole-Breast Ultrasound

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