Visfatin as a predictor for growth of fetus and infant

Taraqi, Ashraf Saber Mashhad; Tehranian, Najmeh; Roudbaneh, Shiva Pourali; Esmaeilzadeh, Matin Sadat; Kazemnejad, Anoshirvan; Aghoozi, Marzieh Faghani; Yousefi, Somayeh

doi:10.4274/tjod.48091

Cited by 5 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A positive correlation of its concentration with neonatal birth weight has been observed by Mazaki-Tovi et al [ 100 ]. Taraqi et al, in turn, found a negative correlation between visfatin levels and infants’ birth weight whose mothers had a BMI higher than normal [ 101 ].…”

Section: Biomoleculesmentioning

confidence: 99%

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Ruszała

Niebrzydowska

Pilszyk

et al. 2021

IJMS

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. It may also affect the later stages of child development and subsequent complications in the mother. Therefore, the crux of the matter is to find a biopredictor capable of singling out women at risk of developing GDM as early as the very start of pregnancy. Apart from the well-known molecules with a proven and clear-cut role in the pathogenesis of GDM, e.g., adiponectin and leptin, a potential role of newer biomolecules is also emphasized. Less popular and less known factors with different mechanisms of action include: galectins, growth differentiation factor-15, chemerin, omentin-1, osteocalcin, resistin, visfatin, vaspin, irisin, apelin, fatty acid-binding protein 4 (FABP4), fibroblast growth factor 21, and lipocalin-2. The aim of this review is to present the potential and significance of these 13 less known biomolecules in the pathogenesis of GDM. It seems that high levels of FABP4, low levels of irisin, and high levels of under-carboxylated osteocalcin in the serum of pregnant women can be used as predictive markers in the diagnosis of GDM. Hopefully, future clinical trials will be able to determine which biomolecules have the most potential to predict GDM.

show abstract

Section: Biomoleculesmentioning

confidence: 99%

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Ruszała

Niebrzydowska

Pilszyk

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Another study positively correlated umbilical cord visfatin levels with fetal birth weight, indicating its potential role in fetal growth regulation [ 105 ]. Taraqi et al found an inverse correlation between visfatin levels and birth weight in patients with higher than normal BMI [ 106 ]. Furthermore, higher levels of this protein were associated with IUGR (defined as birth weight ≤ 3rd customized centile), especially during the third trimester of pregnancy [ 107 , 108 ].…”

Section: Clinical Applications Of Adipokines Measurements In Variomentioning

confidence: 99%

The Role of the Adipokines in the Most Common Gestational Complications

Gutaj

Sibiak

Jankowski

et al. 2020

IJMS

View full text Add to dashboard Cite

Adipocytokines are hormonally active molecules that are believed to play a key role in the regulation of crucial biological processes in the human body. Numerous experimental studies established significant alterations in the adipokine secretion patterns throughout pregnancy. The exact etiology of various gestational complications, such as gestational diabetes, preeclampsia, and fetal growth abnormalities, needs to be fully elucidated. The discovery of adipokines raised questions about their potential contribution to the molecular pathophysiology of those diseases. Multiple studies analyzed their local mRNA expression and circulating protein levels. However, most studies report conflicting results. Several adipokines such as leptin, resistin, irisin, apelin, chemerin, and omentin were proposed as potential novel early markers of heterogeneous gestational complications. The inclusion of the adipokines in the standard predictive multifactorial models could improve their prognostic values. Nonetheless, their independent diagnostic value is mostly insufficient to be implemented into standard clinical practice. Routine assessments of adipokine levels during pregnancy are not recommended in the management of both normal and complicated pregnancies. Based on the animal models (e.g., apelin and its receptors in the rodent preeclampsia models), future implementation of adipokines and their receptors as new therapeutic targets appears promising but requires further validation in humans.

show abstract

“…In our study, a positive correlation was found between visfatin levels and fetal anthropometric parameters, such as weight, length, and head circumference at birth. Mashhad Taraqi & Tehranian (2018) showed an influence of maternal BMI on the correlation between visfatin levels throughout pregnancy and fetal parameters such as weight, length, and head circumference at birth. Furthermore, an association has been reported between serum visfatin levels in the first trimester of pregnancy and final birth weight (Valsamakis et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Apelin and Visfatin Expression in Placental Tissue in Women With Preeclampsia and Overweight/Obesity

Braga

Silva

Lelis

et al. 2023

Biological Research For Nursing

View full text Add to dashboard Cite

Background Preeclampsia (PE) is a multifunctional and multisystem disorder. Several factors favor the development of PE, including obesity. Cytokines are also expressed in the placenta, predisposing to local alterations that favor the development of distinct pathological processes, including PE. This study aimed to evaluate the apelin and visfatin mRNA expression in the placental tissue of women with preeclampsia and overweight/obesity and correlates with maternal and fetal variables. Methods A cross-sectional analytical study was performed with 60 pregnant women and their newborns. Clinical, anthropometric, and laboratory variables were collected. Placental tissue samples were obtained, and the apelin and visfatin mRNA expression levels were assessed by qRT-PCR. Results The main findings evidenced lower levels of apelin expression in overweight/obese women, accompanied by a negative correlation with BMI and pre-pregnancy weight; a higher expression of apelin was also observed in women with late PE and no personal history of PE. For visfatin levels, higher expression levels were observed in women with late PE and term delivery. Furthermore, a positive correlation was observed between visfatin levels and fetal anthropometric parameters, such as weight, length, and head circumference. Conclusion Apelin levels were less expressed in overweight/obese women. Apelin and visfatin levels were correlated/associated with maternal-fetal variables.

show abstract

Visfatin as a predictor for growth of fetus and infant

Cited by 5 publications

References 22 publications

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

The Role of the Adipokines in the Most Common Gestational Complications

Apelin and Visfatin Expression in Placental Tissue in Women With Preeclampsia and Overweight/Obesity

Contact Info

Product

Resources

About