Visfatin and Resistin Serum Levels in Normal-Weight and Obese Women With Polycystic Ovary Syndrome

Abstract

Background:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among women of reproductive age that is linked to insulin resistance and obesity. While studies have shown that plasma levels of resistin and visfatin increase with obesity, the association between PCOS and these markers has not been described well.Objectives:This case-control study aimed to compare the serum levels of visfatin and resistin in women with PCOS in comparison with the healthy controls matched for age and body mass index (BMI).Patients and Methods:A total of 80 women consisted of 40 women with PCOS and 40 matched eumenorrheic women without hyperandrogenism enrolled in the study. They were subcategorized into obese and normal-weight women according to their BMI. Serum visfatin and resistin levels were assessed using sandwich enzyme-linked Immunosorbent assay (ELISA).Results:Serum levels of resistin were higher among both obese and normal-weight women with PCOS in comparison with the controls (2.36 and 1.58 ng/mL in normal-weight women with PCOS and controls, respectively; and 2.10 and 1.91 ng/mL in obese women with PCOS and controls, respectively). Serum visfatin levels was higher in both obese women with PCOS and controls (3.46 and 3.49 ng/mL PCOS and control groups, respectively) in comparison with normal-weight women in both groups (3.16 and 3.15 in PCOS and control groups, respectively); however; there were no statistically significant differences in serum resistin and visfatin levels between PCOS and control groups (P > 0.05).Conclusions:While the expression of visfatin and resistin may be upregulated in women with PCOS, it is not translated at serum level.

High-visfatin levels in women with polycystic ovary syndrome: evidence from a meta-analysis

“…The study by D _ Ikmen et al [23] was treated as multiple separate studies in our meta-analysis due to different BMI and age strategies, as were the studies of Tsouma et al [36], Farshchian et al [8] and Olszanecka-Glinianowicz et al [27]. Therefore, there were 22 studies included in this metaanalysis.…”

“…Among them, visfatin is an adipocytokine with insulin-like activity [8], and elevated plasma visfatin has been reported in patients with metabolic syndrome, especially in obese and T2DM patients [9][10][11][12]. Greater visfatin expression has been also found in cardiovascular diseases [13], inflammatory disorder [14] and a prognosis of cancer [15].…”

“…Over the past decade, some studies have investigated the visfatin levels in women with PCOS; in addition, the relationships between visfatin and PCOS characteristics, such as adiposity, IR and androgen levels, have also been the subject of research [8,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. Yet, these studies have shown conflicting results.…”

The Emerging Role of Chronic Low-Grade Inflammation in the Pathophysiology of Polycystic Ovary Syndrome

“…In a study of PCOS women and matched non-PCOS controls, both free testosterone and visfatin were independent predictors of FMD. [64][65][66][67][68][69][70] While numerous studies have attributed raised visfatin levels to elevated adiposity rather than diagnosis of PCOS per se, 58,59,66,[71][72][73] several other studies have demonstrated increased visfatin levels in women with PCOS when compared with BMI-matched controls. 60,67,68,70,[74][75][76][77][78][79] Furthermore, visfatin mRNA is upregulated in omental adipose tissue in women with PCOS and is closely correlated with BMI and IR.…”

Association of Serum Resistin Level and Resistin (RETN) Gene (-420C>G) Polymorphism in Pakistani Women with Polycystic Ovarian Syndrome

“…In the present study, serum resistin levels were higher in PCOS patients but there was no association in the levels between PCOS cases and controls. Previous studies have described high serum resistin levels in PCOS cases, but the association was not significant (28,30,31). On the other hand, some studies did not find higher serum resistin levels in PCOS women compared to healthy controls (31,32).…”