Visfatin and leptin levels in women with polycystic ovaries undergoing ovarian stimulation

Plati, Ekaterina; Kouskouni, Evangelia; Malamitsi‐Puchner, Ariadne; Boutsikou, Maria; Kaparos, George; Baka, Stavroula

doi:10.1016/j.fertnstert.2009.04.055

Cited by 57 publications

(51 citation statements)

References 44 publications

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“…It has previously been reported that the gene expression and circulating levels of visfatin were increased in women with PCOS compared with age-and BMImatched controls (Tan et al 2006a, Chan et al 2007, Kowalska et al 2007, Panidis et al 2008, Carmina et al 2009, Ozkaya et al 2010, Plati et al 2010, Seow et al 2011, as shown in Table 1. However, several recently published studies did not find a difference in plasma or serum visfatin levels between patients with PCOS and control groups (Guducu et al 2012, Lajunen et al 2012, Olszanecka-Glinianowicz et al 2012.…”

Section: Visfatinmentioning

confidence: 87%

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen¹,

Jia²,

Qiao³

et al. 2013

Journal of Molecular Endocrinology

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

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Section: Visfatinmentioning

confidence: 87%

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen¹,

Jia²,

Qiao³

et al. 2013

Journal of Molecular Endocrinology

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“…We have previously reported that leptin serum levels are higher in overweight/obese PCOS women and also in BMI-matched controls than in normal-weight PCOS and controls (Spritzer et al 2005, Lecke et al 2011a, 2013b. In fact, most published studies about circulating leptin levels in PCOS and controls, including adolescents and pre-and postmenopausal women, stratified or not by BMI, have demonstrated that circulating leptin levels are associated with the amount of body fat, being significantly increased in overweight/obese subgroups, independently of the presence of PCOS (Plati et al 2010, Tan et al 2013. Increased leptin levels observed in obese PCOS (or non-PCOS) are probably secondary to a leptinresistance state and linked to insulin resistance and metabolic comorbidities (Dong & Ren 2014).…”

Section: Leptin and Adiponectinmentioning

confidence: 99%

“…Studies have shown higher visfatin levels in PCOS women as compared with controls of similar BMI and age (Plati et al 2010, Yildiz et al 2010, Cekmez et al 2011. In those studies, PCOS patients were more insulin resistant than control women, leading to the suggestion that visfatin could be a specific marker of insulin sensitivity, possibly contributing to the pathogenesis of PCOS (Plati et al 2010, Yildiz et al 2010, Cekmez et al 2011). In contrast, recent studies do not confirm the association of visfatin with PCOS.…”

Section: Visfatinmentioning

confidence: 99%

Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome

Spritzer¹,

Lecke²,

Satler³

et al. 2015

Reproduction

244

195

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Polycystic ovary syndrome (PCOS), a complex condition that affects women of reproductive age, is characterized by ovulatory dysfunction and androgen excess. Women with PCOS present higher prevalence of obesity, central adiposity, and dyslipidemia, and face increased risk of type 2 diabetes. PCOS is closely linked to functional derangements in adipose tissue. Adipocytes seem to be prone to hypertrophy when exposed to androgen excess, as experienced by women with PCOS, and both adipose tissue hypertrophy and hyperandrogenism are related to insulin resistance. Hypertrophic adipocytes are more susceptible to inflammation, apoptosis, fibrosis, and release of free fatty acids. Disturbed secretion of adipokines may also impact the pathophysiology of PCOS through their influence on metabolism and on sex steroid secretion. Chronic low-grade inflammation in PCOS is also related to hyperandrogenism and to the hypertrophy of adipocytes, causing compression phenomena in the stromal vessels, leading to adipose tissue hypoperfusion and altered secretion of cytokines. Lifestyle changes are the first-line intervention for reducing metabolic risks in PCOS and the addition of an insulin-sensitizing drug might be required. Nevertheless, there is not sufficient evidence in favor of any specific pharmacologic therapies to directly oppose inflammation. Further studies are warranted to identify an adipokine that could serve as an indirect marker of adipocyte production in PCOS, representing a reliable sign of metabolic alteration in this syndrome.

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“…Recent epidemiologic studies have shown direct associations of serum visfatin levels with gastric carcinoma, colorectal adenocarcinoma and postmenopausal breast cancer (27)(28)(29). In addition, a few studies have suggested a link between visfatin and polycystic ovary syndrome, a risk factor for endometrial cancer (30)(31)(32); however, to date, the association of visfatin with endometrial cancer risk has not been evaluated.…”

Section: Introductionmentioning

confidence: 99%

Circulating Adipokine Levels and Endometrial Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Luhn

Dallal

Weiss

et al. 2013

Obstetrical &Amp; Gynecological Survey

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Visfatin and leptin levels in women with polycystic ovaries undergoing ovarian stimulation

Cited by 57 publications

References 44 publications

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome

Circulating Adipokine Levels and Endometrial Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

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