Viscous force during tangential separation of meniscus bridges

Cai, Shurui; Bhushan, Bharat

doi:10.1080/14786430801888850

Cited by 6 publications

(2 citation statements)

References 21 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the presence of a thin aqueous meniscus, two hydrophobic substrates in contact, such as glass and metal, demonstrate strong adhesive forces (Mcfarlane and Tabor, 1950). It is further understood that this adhesive force is formed by a convex-shaped menisci which creates a lower pressure inside the meniscus resulting in an intrinsic attractive force, and during separation the viscosity of the liquid causes an additional attractive force (Cai and Bhushan, 2008a,b). In the case of a polymer probe and silicon shuttle in the brain, this thin aqueous meniscus is formed at the triple junction between polymer, silicon, and extracellular fluid.…”

Section: Discussionmentioning

confidence: 99%

Insertion shuttle with carboxyl terminated self-assembled monolayer coatings for implanting flexible polymer neural probes in the brain

Kozai

Kipke

2009

Journal of Neuroscience Methods

167

146

View full text Add to dashboard Cite

Penetrating microscale microelectrodes made from flexible polymers tend to bend or deflect and may fail to reach their target location. The development of flexible neural probes requires methods for reliable and controlled insertion into the brain. Previous approaches for implanting flexible probes into the cortex required modifications that negate the flexibility, limit the functionality, or restrict the design of the probe. This study investigated the use of an electronegative self-assembled monolayer (SAM) as a coating on a stiff insertion shuttle to carry a polymer probe into the cerebral cortex, and then the detachment of the shuttle from the probe by altering the shuttle’s hydrophobicity. Polydimethylsiloxane (PDMS) and polyimide probes were inserted into an agarose in vitro brain model using silicon insertion shuttles. The silicon shuttles were coated with a carboxyl terminal SAM. The precision of insertion using the shuttle was measured by the percentage displacement of the probe upon shuttle removal after the probe was fully inserted. The average relative displacement of polyimide probes inserted with SAM-coated shuttles was (1.0 ± 0.66)% of the total insertion depth compared to (26.5 ± 3.7)% for uncoated silicon shuttles. The average relative displacement of PDMS probes was (2.1 ± 1.1)% of the insertion depth compared to 100% (complete removal) for uncoated silicon shuttles. SAM-coated shuttles were further validated through their use to reliably insert PDMS probes in the cerebral cortex of rodents. This study found that SAM-coated silicon shuttles are a viable method for accurately and precisely inserting flexible neural probes in the brain.

show abstract

Section: Discussionmentioning

confidence: 99%

Insertion shuttle with carboxyl terminated self-assembled monolayer coatings for implanting flexible polymer neural probes in the brain

Kozai

Kipke

2009

Journal of Neuroscience Methods

167

146

View full text Add to dashboard Cite

show abstract

“…When D s approaches infinity Cai and Bhushan (2008b) calculated the viscous forces during the tangential separation of two flat surfaces and a sphere on a flat surface. They used a couette flow model to derive the equations.…”

Section: Sphere-on-flat Surface With a Separation D 0 During Normal Smentioning

confidence: 99%