2006
DOI: 10.1002/14651858.cd005321.pub2
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Viscosupplementation for the treatment of osteoarthritis of the knee

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Cited by 430 publications
(251 citation statements)
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References 150 publications
(14 reference statements)
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“…Favorable outcomes with viscosupplementation of hyaluronate (HA) and its derivatives have been reported for pain and function associated with knee osteoarthritis (OA) (9), whereas few reports on the use of HA injections in the shoulder have been published (10,11). Recently, the results of the first large, multicenter, double-blind, randomized, saline-controlled study have shown that injection of HA is effective for the treatment of chronic painful shoulder, particularly in patients with glenohumeral OA (12).…”
Section: Introductionmentioning
confidence: 99%
“…Favorable outcomes with viscosupplementation of hyaluronate (HA) and its derivatives have been reported for pain and function associated with knee osteoarthritis (OA) (9), whereas few reports on the use of HA injections in the shoulder have been published (10,11). Recently, the results of the first large, multicenter, double-blind, randomized, saline-controlled study have shown that injection of HA is effective for the treatment of chronic painful shoulder, particularly in patients with glenohumeral OA (12).…”
Section: Introductionmentioning
confidence: 99%
“…Balazs [6] and Balaz and Denlinger [7] proposed correcting OA synovial fluid (SF) disorders by injecting high-molecular-weight hyaluronan acid (HA) and thereby introduced the concept of viscosupplementation (VS). VS by intraarticular injections of HA is used for reducing pain and improving joint mobility in patients with OA of the knee and other synovial joints [5,11] by restoring SF rheologic properties affected in OA. HA is a natural polysaccharide existing in the animal body [28,31,35] and especially in the joints where it plays an important role in lubrication, shock absorption, and viscoelastic behavior of the synovial fluid [8,17,22,39,58].…”
Section: Introductionmentioning
confidence: 99%
“…The MW and residence time in the joint varies between products, and their recommended dosing regimens for the treatment of symptomatic knee OA range from 1 to 5 injections at weekly intervals [6]. The number of injections required to achieve eYcacy is inversely related to the MW of the preparation used and, consequently, to the residence time in the joint.…”
Section: Introductionmentioning
confidence: 99%