Viscosity Study on the Self-Association of Doxorubicin in Aqueous Solution.

Hayakawa, Eiji; Furuya, Kunitoshi; Kuroda, Tokuyuki; Moriyama, Masuo; Kondô, Akira

doi:10.1248/cpb.39.1282

Cited by 19 publications

(18 citation statements)

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“…This method was successfully applied to many liquids when the viscosity measurements were conducted in a relatively narrow range of temperatures (Hayakawa et al 1991;Bourret et al 1994;Lopez da Silva et al 1994;Jauregui et al 1995;de Paula and Rodrigues 1995;Kar and Arslan 1999;de Vasconcelos et al 2000;Desbrieres 2002;Kamimura et al 2006;Durand 2007;Knoben et al 2007). Linear dependence of lnη on T -1 means that the activation energy is constant.…”

Section: Resultsmentioning

confidence: 99%

“…The pre-exponential factor A is considered to be independent or nearly independent of temperature. The above equation is still widely used for different liquids such as solutions of polysaccharides (Lopez da Silva et al 1994;Jauregui et al 1995;de Paula and Rodrigues 1995;Kar and Arslan 1999;de Vasconcelos et al 2000;Desbrieres 2002;Durand 2007), proteins (Tiffany and Koretz 2002), supramolecular polymers (Knoben et al 2007), colloidal suspensions (Gun'ko et al 2006) and others (Hayakawa et al 1991;Bourret et al 1994;Kamimura et al 2006;Magerramov et al 2007). A very convenient way of data presentation in this case is plotting the viscosity versus T -1 in a ln-normal plot.…”

Section: Introductionmentioning

confidence: 99%

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Temperature behaviour of viscous flow with proteins

Monkos¹

2011

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The paper presents the results of viscosity determinations on aqueous solutions of different mammalian serum albumins at a wide range of concentrations and at temperatures ranging from 278 K to 318 K. On the basis of these measurements and a modified Arrhenius equation, the functional dependence of the solution activation energy of viscous flow on temperature was established. The analysis of the results obtained shows that the activation energy decreases with increasing temperature according to a square function for solutions, water molecules, and the albumins studied. The rate at which the activation energy decreases with increasing temperature is different for each albumin and mainly depends on its hydrodynamic radius.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Temperature behaviour of viscous flow with proteins

Monkos¹

2011

gpb

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“…In contrast to the complete or almost complete irinotecan and sunitinib elution (100% and 82%, respectively), doxorubicin was partially retained in the beads under saline flow (28% of drug eluted), which could be attributed to stronger ionic interactions with sulfonates or to doxorubicin in situ gelation (33). Drug physicochemical properties such as solubility and polarity and sterical ligand hindrance govern binding affinity and, in turn, release kinetics in vitro as well as in vivo.…”

Section: Preclinical In Vivo Studies With Healthy New Zealand White Rmentioning

confidence: 99%

Drug-Eluting Beads Loaded with Antiangiogenic Agents for Chemoembolization: In Vitro Sunitinib Loading and Release and In Vivo Pharmacokinetics in an Animal Model

Fuchs

Bize

Dormond

et al. 2014

Journal of Vascular and Interventional Radiology

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Purpose: The combination of embolic beads with a multi-targeted tyrosine kinase inhibitor that inhibits tumor vessel growth is suggested as an alternative and improvement to the current standard doxorubicin-eluting beads for use in transarterial chemoembolization. This study demonstrates the in vitro loading and release kinetics of sunitinib using commercially available embolization microspheres, and evaluates the in vitro biological efficacy on cell cultures and the resulting in vivo pharmacokinetic profiles in an animal model. Materials and Methods:DC Bead microspheres, 70-150 µm and 100-300 µm (Biocompatibles Ltd., Farnham, United Kingdom), were loaded by immersion in sunitinib solution. Drug release was measured in saline in a USP-approved flow-through apparatus and quantified by spectrophotometry. Activity after release was confirmed in cell culture. For pharmacokinetics and in vivo toxicity evaluation, New-Zealand white rabbits received sunitinib either by intra-arterial injection of 100-300 µm sized beads or per os. Drug concentrations in the plasma and liver tissue were assessed by liquid chromatography-tandem mass spectrometry.Results: Sunitinib loading on beads was close to complete and homogeneous. A total release of 80% in saline was measured, with similar fast release profiles for both sphere sizes. After embolization, drug plasma levels remained below the therapeutic threshold (< 50 ng/ml), but high concentrations at 6 h (14.9 µg/g) and 24 h (3.4 µg/g) were found in the liver tissue.Conclusions: DC Bead microspheres of two sizes were efficiently loaded with sunitinib and displayed a fast and almost complete release in saline. High liver drug concentrations and low systemic levels indicated the potential of sunitinib-eluting beads for use in embolization.

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“…This method was successfully applied for many liquids in the case when the viscosity measurements were conducted in a relatively narrow range of temperatures (Hayakawa et al, 1991;Bourret et al, 1994;Lopez da Silva et al, 1994;Jauregui et al, 1995;de Paula & Rodrigues, 1995;Kar & Arslan, 1999;de Vasconcelos et al, 2000;Desbrieres, 2002;Durand, 2007;Knoben et al, 2007). In our case, viscosity measurements were made in a broad range of temperatures.…”

Section: Resultsmentioning

confidence: 99%

A comparison of the activation energy of viscous flow for hen egg-white lysozyme obtained on the basis of different models of viscosity for glass-forming liquids

Monkos¹

2011

Current Topics in Biophysics

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The paper presents the results of viscosity determinations on aqueous solutions of hen egg-white lysozyme at a wide range of concentrations and at temperatures ranging from 5 o C to 55 o C. On the basis of these measurements and different models of viscosity for glass-forming liquids, the activation energy of viscous flow for solutions and the studied protein, at different temperatures, was calculated. The analysis of the results obtained shows that the activation energy monotonically decreases with increasing temperature both for solutions and the studied protein. The numerical values of the activation energy for lysozyme, calculated on the basis of discussed models, are very similar in the range of temperatures from 5 o C to 35 o C.

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Viscosity Study on the Self-Association of Doxorubicin in Aqueous Solution.

Cited by 19 publications

References 0 publications

Temperature behaviour of viscous flow with proteins

Temperature behaviour of viscous flow with proteins

Drug-Eluting Beads Loaded with Antiangiogenic Agents for Chemoembolization: In Vitro Sunitinib Loading and Release and In Vivo Pharmacokinetics in an Animal Model

A comparison of the activation energy of viscous flow for hen egg-white lysozyme obtained on the basis of different models of viscosity for glass-forming liquids

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