Viscosity Plane-wave UltraSound (ViPLUS) in the assessment of parotid and submandibular glands in healthy subjects – preliminary results

Muntean, Delia; Lenghel, Manuela; Ciurea, Andreea; Dudea, Sorin M

doi:10.11152/mu-3397

Cited by 4 publications

(8 citation statements)

References 14 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gender and BMI were not confounding factors of the Vi.PLUS and 2D-SWE.PLUS values in this study. This observation is in accordance with other studies performed on adult populations that assessed MSG using elastography [ 7 , 20 , 21 ] or viscosity [ 6 ].…”

Section: Discussionsupporting

confidence: 93%

“…The normal baseline viscosity values in this study are similar to the ones obtained in one previous preliminary study conducted in our department [ 6 ] for the PG (2.10 ± 0.19 vs. 2.13 ± 0.23 Pa.s) and slightly lower for the SMG (2.31 ± 0.15 vs. 2.44 ± 0.35 Pa.s), differences possibly related to a narrower age range for the subjects included in the current study.…”

Section: Discussionsupporting

confidence: 89%

“…Reference viscosity values of major salivary glands (MSG) in healthy subjects have been proposed [ 6 ]. However, to the best of our knowledge, no functional studies using viscoelastography have been performed so far.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functional Evaluation of Major Salivary Glands Using Viscosity PLUS and 2D Shear-Wave PLUS Elastography Techniques in Healthy Subjects—A Pilot Study

et al. 2022

View full text Add to dashboard Cite

Biological soft tissues are characterized by viscoelastic properties. The propagation of shear waves within tissues is influenced by both elasticity, which is linked to the shear wave speed, and viscosity, which is linked to the shear wave dispersion. This study aimed to functionally assess the parotid glands (PG) and submandibular glands (SMG) in a group of 40 healthy subjects using the novel Viscosity PLUS (Vi.PLUS) and 2D Shear-Wave Elastography PLUS (2D-SWE.PLUS) techniques. The viscosity and stiffness of PG and SMG were measured before and after gustatory stimulation with a sialagogue agent (commercially available lemon juice) using the new SuperSonic MACH 30 ultrasound system equipped with a curvilinear C6-1X transducer. PG presented a mean basal viscosity and elasticity of 2.10 ± 0.19 Pa.s and 11.32 ± 1.91 kPa, respectively, which significantly increased poststimulation to 2.39 ± 0.17 Pa.s (p < 0.001) and 12.58 ± 1.92 kPa (p < 0.001), respectively. SMG did not present statistically increased values of viscosity and elasticity following stimulation (2.31 ± 015 Pa.s vs. 2.37 ± 0.18 Pa.s, p = 0.086, and 10.40 ± 1.64 kPa vs. 10.90 ± 1.98 kPa, p = 0.074, respectively). Vi.PLUS measurements presented a good positive correlation with 2D-SWE.PLUS values for PG and SMG, before and after stimulation. Gender and BMI were not confounding factors for these two parameters. Vi.PLUS represents an innovative non-invasive imaging technique that, together with 2D-SWE.PLUS proves to be useful in functionally assessing the major salivary glands in healthy subjects.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Functional Evaluation of Major Salivary Glands Using Viscosity PLUS and 2D Shear-Wave PLUS Elastography Techniques in Healthy Subjects—A Pilot Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…To date, only a few studies have evaluated the potential of this recent ultrasound technique. Muntean et al [ 9 , 20 ] prospectively evaluated the capability of Vi PLUS in establishing reference values for the parotid and submandibular glands in healthy subjects and also evaluated the functional changes in major salivary glands in healthy subjects. Popa et al [ 5 ] studied the role of viscosity using Vi PLUS mode in patients with liver steatosis, fibrosis, and inflammation in patients with non-alcoholic fatty liver disease (NAFLD) and concluded there is an independent association between viscosity values and liver stiffness values.…”

Section: Discussionmentioning

confidence: 99%

“…Viscosity Plane-wave UltraSound (Vi PLUS) 2D imaging performed via the new Aixplorer MACH 30 system (SuperSonic Imagine, Aix-en-Provence, France) represents a 2D imaging mode that provides visualization and quantification of tissue viscosity. The result is a local measurement of the tissue viscosity at each point of interest in an organ, expressed in pascal second (Pa.s) [ 6 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Viscosity Plane-Wave UltraSound (Vi PLUS) in the Evaluation of Thyroid Gland in Healthy Volunteers—A Preliminary Study

et al. 2022

View full text Add to dashboard Cite

Viscosity and elasticity represent biomechanical properties of soft tissues that suffer changes during the pathophysiological alterations of the tissue in various conditions. This study aimed to determine average viscosity values for the thyroid gland and to evaluate the potential influences of age, gender and body mass index (BMI), using a recent technique Viscosity Plane-wave UltraSound (Vi PLUS). A total of 85 healthy Caucasian volunteers (56 women and 29 men, median age of 29 years, range 17–81 years) were included in this prospective monocentric study conducted between January 2022 and March 2022. Thyroid viscosity was measured using the SuperSonic MACH 30® Ultrasound system (Aixplorer, SuperSonic Imagine, Aix-en-Provence, France), equipped with a curvilinear C6-IX transducer that allows simultaneous quantification of the viscosity and stiffness. The mean thyroid viscosity measurement value was 2.63 ± 0.47 Pa.s. No statistically significant differences were detected between the left and the right lobes of the thyroid gland. A significant positive correlation was found between thyroid viscosity and elasticity (r = 0.685, p < 0.0001). There was no statistically significant correlation between body mass index (BMI) and thyroid gland viscosity and elasticity values (r = 0.215, p = 0.053; r = 0.106, p = 0.333). No correlation between viscosity and gender was established (p > 0.05). Vi PLUS represents a new and promising ultrasonographic technique that can provide helpful information for evaluating the thyroid parenchyma, similar to elastography. The effect of the potential confounding factors on thyroid viscosity was negligible, except for BMI.

show abstract

Systematic quantification of differences in shear wave elastography estimates between linear-elastic and viscoelastic material assumptions

Bisht,

Paul,

Patel

et al. 2024

The Journal of the Acoustical Society of America

View full text Add to dashboard Cite

Quantitative, accurate, and standardized metrics are important for reliable shear wave elastography (SWE)-based biomarkers. For over two decades, the linear-elastic material assumption has been employed in SWE modes. In recent years, viscoelasticity estimation methods have been adopted in a few clinical systems. The current study aims to systematically quantify differences in SWE estimates obtained using linear-elastic and viscoelastic material assumptions. An acousto-mechanical simulation framework of acoustic radiation force impulse-based SWE was created to elucidate the effect of material viscosity and shear modulus on SWE estimates. Shear modulus estimates exhibited errors up to 72% when a numerical viscoelastic phantom was assessed as linearly elastic. Shear modulus estimates of polyvinyl alcohol phantoms between rheometry and SWE following the Kelvin-Voigt viscoelastic model assumptions were not significantly different. However, the percentage difference in shear modulus estimates between rheometry and SWE using the linear-elastic assumption was 50.1%–62.1%. In ex vivo liver, the percentage difference in shear modulus estimates between linear-elastic and viscoelastic methods was 76.1%. These findings provide a direct and systematic quantification of the potential error introduced when viscoelastic tissues are imaged with SWE following the linear-elastic assumption. This work emphasizes the need to utilize viscoelasticity estimation methods for developing robust quantitative imaging biomarkers.

show abstract

Viscosity Plane-wave UltraSound (ViPLUS) in the assessment of parotid and submandibular glands in healthy subjects – preliminary results

Cited by 4 publications

References 14 publications

Functional Evaluation of Major Salivary Glands Using Viscosity PLUS and 2D Shear-Wave PLUS Elastography Techniques in Healthy Subjects—A Pilot Study

Functional Evaluation of Major Salivary Glands Using Viscosity PLUS and 2D Shear-Wave PLUS Elastography Techniques in Healthy Subjects—A Pilot Study

Viscosity Plane-Wave UltraSound (Vi PLUS) in the Evaluation of Thyroid Gland in Healthy Volunteers—A Preliminary Study

Systematic quantification of differences in shear wave elastography estimates between linear-elastic and viscoelastic material assumptions

Contact Info

Product

Resources

About