This paper presents the improvement of eco-friendly and power consumption saving refrigerants for refrigeration systems. The novel azeotropic refrigerant mixtures of HFCs and HCs can replace refrigeration systems, and using the R134, R32, R125, and R1270 refrigerants in several compositions found using the decision tree function of the RapidMiner software (which came first in the KDnuggets annual software poll). All refrigerant results are mixed of POE, which is A1 classification refrigerant, non-flammable, and innocuous refrigerant, and using REFPROP software and CYCLE_D-HX software are under the CAN/ANSI/AHRI540 standards. The boiling point of the new refrigerant mix R-No.595 is 4.58%, lower than that of R404A, with a higher refrigerant effect and 50.34% lower GWP value than R404A. The proposed mix R-No.595 can be operated in hot environmental country and has high critical temperature and heat-rejection effects, due to the presence of R32 and R1270. The COPc of R463A is 13.49%, higher than R404A in freeze condition. The novel refrigerant mixes provide alternate refrigerant options mixed of 1% R1270, and which are related with the development of current refrigerants, containing a compose of HFOs and eco refrigerants for producing low-GWP, zero ODP, high-refrigerant effect, low-operating pressure, and innocuous refrigerants.