Viscoelasticity of hyaluronic acid with different molecular weights

Kobayashi, Y.; Okamoto, Akio; Nishinari, K.

doi:10.3233/bir-1994-31302

Cited by 167 publications

(128 citation statements)

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“…Although this property of HA is more helpful in orthopaedic surgery, it also requires more chemical stabilization and structural stability. The length of the chain, degree of entanglement, cross linking, pH, chemical variations all effect the viscosity of the gel [172,173].…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

Water Soluble Polymers for Pharmaceutical Applications

2011

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Advances in polymer science have led to the development of novel drug delivery systems. Some polymers are obtained from natural resources and then chemically modified for various applications, while others are chemically synthesized and used. A large number of natural and synthetic polymers are available. In the present paper, only water soluble polymers are described. They have been explained in two categories (1) synthetic and (2) natural. Drug polymer conjugates, block copolymers, hydrogels and other water soluble drug polymer complexes have also been explained. The general properties and applications of different water soluble polymers in the formulation of different dosage forms, novel delivery systems and biomedical applications will be discussed.

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Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

Water Soluble Polymers for Pharmaceutical Applications

2011

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“…the rheological behavior of HA is that of a semirigid polymer having a persistence length of the order of 70 Å. 15,16 It displays an original viscoelastic character in the entangled regime, [17][18][19][20][21] where the polymer concentration is larger than the overlap concentration. NMR spectroscopy allowed the proposal of an hydrogen bond network to describe the conformation of HA in aqueous solution and its interactions with water molecules.…”

Section: Introductionmentioning

confidence: 99%

Hydration of polysaccharide hyaluronan observed by IR spectrometry. I. Preliminary experiments and band assignments

Haxaire¹,

Maréchal²,

Milas³

et al. 2002

Biopolymers

193

152

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This article is the first one in a series dedicated to the study of hyaluronan as observed by IR spectrometry. The goal is to determine its hydration mechanism and the structural changes this mechanism implies. Hyaluronan is a natural polysaccharide that is widely used in biomedical applications and cosmetics. Its macroscopic properties are significantly dependent on its degree of hydration. In this article we record the IR spectrum of a several micron thick dried film and deduce that four or five residual H 2 O molecules remain around each disaccharide repeat unit in the dried film. We then compare the spectra of sodium hyaluronan and its acid form to assign vibrational bands linked to the carboxylate group. We proceed with a qualitative analysis of the spectral changes induced by changes of temperature and hygroscopicity, two independent parameters that act by modifying the hydrogen bond network of the sample. This enables us to assign most of the vibrational bands of the hydrophilic groups and to distinguish the bands that are due to these hydrophilic groups when they are or are not hydrogen bonded. It constitutes a prerequisite for the quantitative analysis of hydration spectra that will be described in the following articles of this series.

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“…13 Nevertheless, high molecular weight (MW  17 × 10 6 ) HA produces high viscosity solutions by extending the degree of entanglement which cannot be achieved simply by increasing the concentration of low molecular weight HA. 15 The extreme aqueous solubility and high turnover rate of HA in the body limit its application in tissue engineering. While maintaining the viscoelasticity, the physio-chemical properties of HA have been improved by chemical crosslinking and modification such as esterification to reduce the solubility and increase its stability and biocompatibility.…”

Section: Dovepressmentioning

confidence: 99%

Hyaluronan: its potential application in intervertebral disc regeneration

Shen

Wei²,

Bhargav³

et al. 2010

ORR

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Hyaluronan (HA) is a ubiquitous component of extracellular matrix in human tissues with diverse functions in skeletal biology. The biophysical properties of HA, such as high viscosity, elasticity and highly negative charge, make it useful in various therapeutic procedures. Although intra-articular administration of HA has been extensively used in the management of osteoarthritis (OA), there is a paucity of data on the clinical application of HA in intervertebral disc repair. This review discusses the biology and signaling mechanisms of HA, the pathophysiology of disc degeneration and summarises current evidence relating to the role of HA in cell phenotype maintenance, differentiation of chondrocytes, intervertebral disc cells and bone marrow stromal cells, and its application in tissue engineering. Based on recent advances in the clinical outcomes of OA treatment, HA has demonstrated potential as a bio-polymer filler, therapeutic agent and cell carrier in the management of intervertebral disc degeneration.

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Viscoelasticity of hyaluronic acid with different molecular weights

Cited by 167 publications

References 0 publications

Water Soluble Polymers for Pharmaceutical Applications

Water Soluble Polymers for Pharmaceutical Applications

Hydration of polysaccharide hyaluronan observed by IR spectrometry. I. Preliminary experiments and band assignments

Hyaluronan: its potential application in intervertebral disc regeneration

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