Viscoelasticity Measurement in Rat Livers Using Shear-Wave US Elastography

Sugimoto, Katsutoshi; Moriyasu, Fuminori; Oshiro, Hisashi; Takeuchi, Hirohito; Yoshimasu, Yu; Kasai, Yoshitaka; Furuichi, Yoshihiro; Itoi, Takao

doi:10.1016/j.ultrasmedbio.2018.05.008

Cited by 83 publications

(112 citation statements)

References 22 publications

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“…SWD might be used as an additional new method to evaluate diffuse liver disease and FLLs [29]. In our preliminary clinical study, a new ultrasound elastography method based on the analysis of SWD was used to obtain quantitative measurements of SWD slope (m/s/kHz), which is related to viscosity values in benign and malignant FLLs [27]. Histopathological features after operation were used as reference standards.…”

Section: Discussionmentioning

confidence: 99%

“…If a tissue is dispersive, the speed and the attenuation of shear waves will increase with frequency. Early differentiation diagnosis of FLLs is critical and is suggested to take liver viscosity into account [27][28][29]. Since SWD assesses the frequency dispersion of shear waves, it might be used as an additional new method to evaluate characterization of diffuse liver disease and FLLs [21,25,30].…”

Section: Introductionmentioning

confidence: 99%

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Preliminary Clinical Experience with Shear Wave Dispersion Imaging for Liver Viscosity in Preoperative Diagnosis of Focal Liver Lesions

Qiu

Zhang

et al. 2020

Z Gastroenterol

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Background The aim of our study is to analyze viscosity characteristics of focal liver lesions (FLLs) and the diagnostic performance of shear wave dispersion (SWD) in differentiating benign and malignant FLLs. Methods Between January 2018 and April 2018, 58 consecutive patients (median age 57, age range 21–74 years, 37 males) with 58 FLLs located on the right lobe of liver were prospectively studied. The Aplio i900 series diagnostic ultrasound system (Canon Medical systems) equipped with a curvilinear PV1-475BX transducer (1–8 MHz) was used. SWD slope and viscosity measurements were expressed as mean ± standard deviation for both liver tumors and background liver parenchyma. Histopathological results after surgery were regarded as the gold standard for diagnosis. Results Final diagnosis included 40 cases of malignant and 18 cases of benign FLLs. The mean viscosity value were 14.78 ± 1.86 m/s/kHz for hepatocellular carcinoma (n = 30), 14.81 ± 2.35 m/s/kHz for liver metastasis lesions (n = 10), 13.23 ± 1.31 m/s/kHz for hemangioma (n = 13), and 13.67 ± 2.72 m/s/kHz for focal nodular hyperplasia (n = 5). Malignant FLLs showed higher mean viscosity values (14.79 ± 3.15 m/s/KHz) than benign FLLs (13.36 ± 2.76 m/s/KHz) (p < 0.05). The best performing cut-off value of lesion viscosity was 13.15 m/s/kHz (sensitivity 83.3 %; specificity 56.5 %; area under the curve (AUC) 0.71) for malignancy) (p < 0.05). Conclusions The analysis of SWD slope and liver viscosity parameters provide additional viscoelastic information about FLLs before operation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preliminary Clinical Experience with Shear Wave Dispersion Imaging for Liver Viscosity in Preoperative Diagnosis of Focal Liver Lesions

Qiu

Zhang

et al. 2020

Z Gastroenterol

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“…Using the fast Fourier transform algorithm, each displacement caused by shear waves can be transformed from the time domain to the frequency domain. Finally, from shear wave speed and frequency, SWD can be estimated as a phase domain, and is calculated in units of (m/sec)/kHz [8,11]. Since 2D-SWI was introduced, several preliminary studies have reported the clinical significance of SWD in various hepatic diseases, both in a rat model and in human patients [8,11,21,22].…”

Section: Discussionmentioning

confidence: 99%

Added value of 2D shear wave imaging of the gallbladder bed of the liver for acute cholecystitis

Lee

Park

et al. 2020

Ultrasonography

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Epub ahead of printPurpose: The purpose of this study was to evaluate whether shear wave elastography (SWE) and the shear wave dispersion slope (SWD) obtained from 2-dimensional shear wave imaging (2D-SWI) of the gallbladder (GB) bed of the liver could be helpful in the diagnosis of acute cholecystitis. Methods: We included 44 patients referred for abdominal ultrasonography (US) under the impression of acute cholecystitis from April 2018 to March 2019. Patients with chronic liver disease were excluded from this study. In addition to routine upper abdominal US, we performed 2D-SWI including liver stiffness measurements by SWE and SWD, which reflects tissue viscosity. 2D-SWI was performed at the GB bed of the liver through the right intercostal approach at least 3 times with different frames. We assessed typical US findings and the added value of 2D-SWI in diagnosing acute cholecystitis. Histopathologic results of surgical specimens were used as the standard of reference. If a surgical specimen was unavailable, a bile fluid test or clinical followup for more than 3 months served as the reference standard. Results: The optimal cutoff values for SWE and SWD were 8 kPa and 10.9 (m/sec)/kHz, respectively. In the univariate analysis, SWE, GB distension, and sludge were predictive factors of acute cholecystitis. In the multivariate analysis, categorized SWE was the only significant predictor (P<0.01). By using 2D-SWI, the diagnostic performance of two readers did not significantly increase, although the inter-reader agreement improved (k=0.654-0.778). Conclusion: 2D-SWI of the GB bed of the liver could be helpful for diagnosing acute cholecystitis.

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“…The shear wave velocity is used as a surrogate measure of tissue stiffness, but the tissue stiffness may also be reported in kilopascals. Dispersion and attenuation of the shear wave are unique parameters that can provide additional information, although the exact applications to nerve and muscle disease remain unknown . A sample figure of a shear wave recorded within the median nerve is provided (Figure ).…”

Section: Shear Wave Elastographymentioning

confidence: 99%

Emerging technologies in neuromuscular ultrasound

Hobson‐Webb

2020

Muscle and Nerve

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Neuromuscular ultrasound is an accepted and valuable element in the evaluation of peripheral nerve and muscle disease. However, ultrasound has several limitations to consider, including operator dependency and lack of a viable contrast agent. Fortunately, new technological advances show promise in resolving these issues. Ultrahigh resolution ultrasound enables imaging of the nerve at the fascicular level. Shear wave elastography imaging can provide measures of tissue stiffness that can act as a surrogate measure of nerve and muscle health. Photoacoustic imaging may overcome neuromuscular ultrasound's current lack of contrast agents to detect inflammation and other functional changes within nerve and muscle, while artificial intelligence stands to address operator dependency and improve diagnostic imaging. The basic principles of each of these technologies are discussed along with current research and potential future applications in neuromuscular imaging. K E Y W O R D S artificial intelligence, elastography, high resolution ultrasound, neuromuscular ultrasound, photoacoustic imaging

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Viscoelasticity Measurement in Rat Livers Using Shear-Wave US Elastography

Cited by 83 publications

References 22 publications

Preliminary Clinical Experience with Shear Wave Dispersion Imaging for Liver Viscosity in Preoperative Diagnosis of Focal Liver Lesions

Preliminary Clinical Experience with Shear Wave Dispersion Imaging for Liver Viscosity in Preoperative Diagnosis of Focal Liver Lesions

Added value of 2D shear wave imaging of the gallbladder bed of the liver for acute cholecystitis

Emerging technologies in neuromuscular ultrasound

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