Viscoelasticity in natural tissues and engineered scaffolds for tissue reconstruction

Huang, Danyang; Huang, Yong; Xiao, Yun; Lin, Hai; Feng, Ganjun; Zhu, Xiangdong; Zhang, Xingdong

doi:10.1016/j.actbio.2019.08.013

Cited by 98 publications

(84 citation statements)

References 208 publications

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“…However, AFM only measures the surface stiffness rather than the interior of the sample. Shearwave Dispersion Ultrasound Vibrometry (SDUV) SDUV allows tissue elasticity and viscosity to be measured noninvasively using imaging techniques [185].…”

Section: Atomic Force Microscopy (Afm)mentioning

confidence: 99%

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Adipose Tissue Fibrosis: Mechanisms, Models, and Importance

DeBari

Abbott

2020

IJMS

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Increases in adipocyte volume and tissue mass due to obesity can result in inflammation, further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like other fibrotic diseases, adipose tissue fibrosis is the accumulation and increased production of extracellular matrix (ECM) proteins. Adipose tissue fibrosis has been linked to decreased insulin sensitivity, poor bariatric surgery outcomes, and difficulty in weight loss. With the rising rates of obesity, it is important to create accurate models for adipose tissue fibrosis to gain mechanistic insights and develop targeted treatments. This article discusses recent research in modeling adipose tissue fibrosis using in vivo and in vitro (2D and 3D) methods with considerations for biomaterial selections. Additionally, this article outlines the importance of adipose tissue in treating other fibrotic diseases and methods used to detect and characterize adipose tissue fibrosis.

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Section: Atomic Force Microscopy (Afm)mentioning

confidence: 99%

“…MRE is a magnetic resonance imaging (MRI) technique. MRE allows for mechanical properties, like stiffness, to be investigated noninvasively using imaging techniques [185].…”

Section: Magnetic Resonance Elastography (Mre)mentioning

confidence: 99%

Adipose Tissue Fibrosis: Mechanisms, Models, and Importance

DeBari

Abbott

2020

IJMS

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“…Cells in tissues and organs are surrounded by extracellular matrix (ECM), a complex and highly organized bioactive structure that provides mechanical support and guides cell adhesion, proliferation and differentiation. 1,2 Hydrogels are threedimensional (3D) water-swollen polymer networks and ideal candidates to mimic the intricate and organized network of the native ECM, due to their high water content, viscoelasticity, and biocompatibility. 3,4 Importantly, polymers can be molecularly engineered to make hydrogels biodegradable, and their mechanical and physical properties can be tuned to mimic those of native tissues.…”

Section: Introductionmentioning

confidence: 99%

Rapid and cytocompatible cell-laden silk hydrogel formation via riboflavin-mediated crosslinking

et al. 2020

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“…Under dynamic loading conditions, the viscoelasticity of hydrogels can be significantly depending on strain rate. Remarkable efforts and progress have been made in recent years toward the development of advanced viscoelastic hydrogels, with certain results showing that the hydrogel viscoelasticity may greatly influence cell morphology, proliferation and differentiation ( Chaudhuri et al, 2015 , 2016 ; Bauer et al, 2017 ; Charrier et al, 2018 ; Gong et al, 2018 ; Lou et al, 2018 ; Huang D. et al, 2019 ; Cantini et al, 2020 ). In addition to viscoelasticity, some hydrogels (especially reconstituted fibrous hydrogels such as type I collagen) may undergo plastic deformation (a non-reversible permanent change in shape) when subjected to mechanical loadings ( Kim et al, 2017 ; Ban et al, 2018 ; Ming et al, 2020 ).…”

Section: Engineering Biomaterials For Mechanical Stretching Of Cells mentioning

confidence: 99%

Engineering Biomaterials and Approaches for Mechanical Stretching of Cells in Three Dimensions

Zhang

Huang

2020

Front. Bioeng. Biotechnol.

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Mechanical stretch is widely experienced by cells of different tissues in the human body and plays critical roles in regulating their behaviors. Numerous studies have been devoted to investigating the responses of cells to mechanical stretch, providing us with fruitful findings. However, these findings have been mostly observed from two-dimensional studies and increasing evidence suggests that cells in three dimensions may behave more closely to their in vivo behaviors. While significant efforts and progresses have been made in the engineering of biomaterials and approaches for mechanical stretching of cells in three dimensions, much work remains to be done. Here, we briefly review the state-of-the-art researches in this area, with focus on discussing biomaterial considerations and stretching approaches. We envision that with the development of advanced biomaterials, actuators and microengineering technologies, more versatile and predictive three-dimensional cell stretching models would be available soon for extensive applications in such fields as mechanobiology, tissue engineering, and drug screening.

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Viscoelasticity in natural tissues and engineered scaffolds for tissue reconstruction

Cited by 98 publications

References 208 publications

Adipose Tissue Fibrosis: Mechanisms, Models, and Importance

Adipose Tissue Fibrosis: Mechanisms, Models, and Importance

Rapid and cytocompatible cell-laden silk hydrogel formation via riboflavin-mediated crosslinking

Engineering Biomaterials and Approaches for Mechanical Stretching of Cells in Three Dimensions

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