Viscoelastic Transient of Confined Red Blood Cells

Prado, Gaël; Farutin, Alexander; Misbah, Chaouqi; Bureau, Lionel

doi:10.1016/j.bpj.2015.03.046

Cited by 49 publications

(58 citation statements)

References 54 publications

(104 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15(a)), lead to transition times that span between 10 and 70 ms. This is in agreement with stop-and-go experiments in a channel performed in Prado et al (2015). The only longer transition time found here is when decreasingγ so as to switch from tank-treading regime to coexistence between tank-treading and flipping: see final transition in Fig.…”

Section: Transition Times and Intermittent Regimessupporting

confidence: 91%

Dynamics of a large population of red blood cells under shear flow

et al. 2019

View full text Add to dashboard Cite

An exhaustive description of the dynamics under shear flow of a large number of red blood cells in dilute regime is proposed, which highlights and takes into account the dispersion in cell properties within a given blood sample. Physiological suspending fluid viscosity is considered, a configuration surprisingly seldom considered in experimental studies, as well as a more viscous fluid that is a reference in the literature. Stable and unstable flipping motions well described by Jeffery orbits or modified Jeffery orbits are identified, as well as transitions to and from tank-treading motion in the more viscous suspending fluid case. Hysteresis loops upon shear rate increase or decrease are highlighted for the transitions between unstable and stable orbits as well as for the transition between flipping and tank-treading. We identify which of the characteristic parameters of motion and of the transition thresholds depend on flow stress only or also on suspending fluid viscosity.

show abstract

Section: Transition Times and Intermittent Regimessupporting

confidence: 91%

Dynamics of a large population of red blood cells under shear flow

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It is thus likely that we are measuring a Figure 2. Phase response of the probe particle of radius 1.5 μm in 0.008% w/w PAM to water solution with driving frequency along with a fit to the data using equation (4). The measured trap stiffness is 48(3) μN m −1 .…”

Section: Resultsmentioning

confidence: 99%

“…Phase response of the spherical probe of radius 1.5 μm in water as a function of driving frequency along with a fit to the data using equation(4). The measured trap stiffness is 52(4) μN m −1 .…”

mentioning

confidence: 99%

Active microrheology to determine viscoelastic parameters of Stokes-Oldroyd B fluids using optical tweezers

2019

View full text Add to dashboard Cite

We use active microrheology to determine the frequency dependent moduli of a linear viscoelastic fluid in terms of the polymer time constant (λ), and the polymer (μ p ) and solvent viscosity (μ s ), respectively. We measure these parameters from the response function of an optically trapped Brownian probe in the fluid under an external perturbation, and at different dilutions of the viscoelastic component in the fluid. This is an improvement over bulk microrheology measurements in viscoelastic Stokes-Oldroyd B fluids which determine the complex elastic modulus G(ω) of the fluid, but do not, however, reveal the characteristics of the polymer chains and the Newtonian solvent of the complex fluid individually. In a recent work (Paul et al 2018 J. Phys. Condens. Matter 30, 345101), we linearized the Stokes-Oldroyd B fluid model and thereby explicitly formulated the frequency dependent moduli in terms of μ p , μ s and λ which we now extend to account for an external sinusoidal force applied to the probe particle. We measure λ, μ p , and μ s experimentally, and compare with the existing λ values in the literature for the same fluid at some of the dilution levels, and obtain good agreement. Further, we use these parameters to calculate the complex elastic modulus of the fluid again at certain dilutions and verify successfully with existing data. This establishes our method as an alternate approach in the active microrheology of complex fluids which should reveal information about the composition of such fluids in significantly greater detail and high signal to noise.

show abstract

“…It may be viewed also as the ratio between the characteristic shape relaxation time τ c (eq. RBCs [48][49][50].…”

Section: Dimensionless Formmentioning

confidence: 99%

Hydrodynamic pairing of soft particles in a confined flow

et al. 2017

View full text Add to dashboard Cite

The mechanism of hydrodynamics-induced pairing of soft particles, namely closed bilayer membranes (vesicles, a model system for red blood cells) and drops, is studied numerically with a special attention paid to the role of the confinement (the particles are within two rigid walls). This study unveils the complexity of the pairing mechanism due to hydrodynamic interactions. We find both for vesicles and for drops that two particles attract each other and form a stable pair at weak confinement if their initial separation is below a certain value. If the initial separation is beyond that distance, the particles repel each other and adopt a longer stable interdistance. This means that for the same confinement we have (at least) two stable branches. To which branch a pair of particles relaxes with time depends only on the initial configuration. An unstable branch is found between these two stable branches. At a critical confinement the stable branch corresponding to the shortest interdistance merges with the unstable branch in the form of a saddle-node bifurcation. At this critical confinement we have a finite jump from a solution corresponding to the continuation of the unbounded case to a solution which is induced by the presence of walls. The results are summarized in a phase diagram, which proves to be of a complex nature. The fact that both vesicles and drops have the same qualitative phase diagram points to the existence of a universal behavior, highlighting the fact that with regard to pairing the details of mechanical properties of the deformable particles are unimportant. This offers an interesting perspective for simple analytical modeling.

show abstract

Viscoelastic Transient of Confined Red Blood Cells

Cited by 49 publications

References 54 publications

Dynamics of a large population of red blood cells under shear flow

Dynamics of a large population of red blood cells under shear flow

Active microrheology to determine viscoelastic parameters of Stokes-Oldroyd B fluids using optical tweezers

Hydrodynamic pairing of soft particles in a confined flow

Contact Info

Product

Resources

About