2013
DOI: 10.1016/j.jbiomech.2012.12.024
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Viscoelastic properties of the ferret brain measured in vivo at multiple frequencies by magnetic resonance elastography

Abstract: Characterization of the dynamic mechanical behavior of brain tissue is essential for understanding and simulating the mechanisms of traumatic brain injury (TBI). Changes in mechanical properties may also reflect changes in the brain due to aging or disease. In this study, we used magnetic resonance elastography (MRE) to measure the viscoelastic properties of ferret brain tissue in vivo. Three-dimensional (3D) displacement fields were acquired during wave propagation in the brain induced by harmonic excitation … Show more

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Cited by 67 publications
(67 citation statements)
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“…Recent indentation tests have shown that gray and white matter display rather similar stiffnesses, both of the order of 1kPa [11]. These values agree with recent in vivo measurements using magnetic resonance elastography [16]. Introducing white matter growth makes cortical folding possible, even for small stiffness contrasts [5].…”
Section: Discussionsupporting
confidence: 76%
“…Recent indentation tests have shown that gray and white matter display rather similar stiffnesses, both of the order of 1kPa [11]. These values agree with recent in vivo measurements using magnetic resonance elastography [16]. Introducing white matter growth makes cortical folding possible, even for small stiffness contrasts [5].…”
Section: Discussionsupporting
confidence: 76%
“…Magnetic resonance elastography measures the mechanical properties of soft tissues by introducing shear waves and assessing their propagation velocity using magnetic resonance imaging. A recent study in ferrets suggested that, at loading rates from 400Hz to 800Hz, elastic and viscous properties of gray and white matter were indistinguishable [12]. Another study in humans at loading rates of 200Hz found that gray matter storage moduli, with 3.1kPa, were on average 12% larger than white matter storage moduli, with 2.7kPa, while loss moduli of gray and white matter, with 2.5kPa, were identical [21].…”
Section: Discussionmentioning
confidence: 99%
“…While five decades of research have generated a profound understanding of brain tissue as a whole [7], the individual rheology of gray and white matter remains understudied and poorly understood. As a result of inconsistent sample preparation, post-mortem time, and testing conditions, reported stiffness values are often irreproducible and may vary by an order of magnitude or more [35]: Some studies reported that gray matter was substantially stiffer than white matter [9], others found that they were of equal stiffness [12], and yet others observed that white matter was stiffer [45]. Here, to address this discrepancy, we adopt a robust, reliable, and repeatable method to quantify the mechanical properties of gray and white matter, flat-punch indentation.…”
Section: Motivationmentioning
confidence: 99%
“…Riek et al (2011) reported that G′ of a gelatin gel measured by MRE increased with the frequency between 100 and 800 Hz. Feng et al (2013) also measured the G′ and G″ of ferret brains in vivo by MRE in the excitation frequency of 400-800 Hz and that the complex shear modulus increased with the frequency. The viscoelastic modulus of agarose gels was measured using the MRE system under the excitation conditions.…”
Section: Discussionmentioning
confidence: 98%