Visceral Response to Subcutaneous and Intraperitoneal Injections of Silicone in Mice

Rees, Thomas D.; Ballantyne, Donald L.; Seidman, Irving; Hawthorne, Gail A.

doi:10.1097/00006534-196704000-00011

Cited by 107 publications

(25 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 They coined the term "siliconoma" to describe this process and subsequently reproduced these changes following intraperitoneal silicone injections in mice. 8 However, none of the reports indicate the presence of progressively enlarging masses that created such significant anatomical distortion as that which occurred in our 3 patients. We can speculate as to the mechanism causing this local soft-tissue reaction.…”

Section: Discussioncontrasting

confidence: 53%

Solid noninfectious growing masses over cerebrospinal fluid shunts: report of 3 cases

James

Postlethwait

Sandler

2015

PED

View full text Add to dashboard Cite

The authors describe 3 children who presented with progressively enlarging skin-covered solid masses over the shunt catheter in the neck/clavicular region. The authors reviewed the clinical, laboratory, pathological, radiographic, and follow-up data for all 3 patients and reviewed the literature on the subject. The patients had no clinical evidence of an infectious process. Surgical exploration revealed that masses were surrounding and encasing the shunt tubing to which they were strongly attached. Pathological studies of the tissues demonstrated varying degrees of exuberant chronically inflamed granulation tissues, interstitial fibrosis, and dystrophic calcification. One patient had associated thinning of the skin overlying the mass and subsequently developed ulceration. No infectious organisms were observed. The cerebrospinal fluid aspirates from the shunts did not yield any organisms. There has been no recurrence of the masses. The presence of a growing mass over the shunt tube in the neck or the chest region without clinical evidence of infection does not indicate that the mass should be treated with antibiotics and complete shunt removal. Rather, the mass can be cured by extirpation and with “bypass” new shunt tubing locally.

show abstract

Section: Discussioncontrasting

confidence: 53%

Solid noninfectious growing masses over cerebrospinal fluid shunts: report of 3 cases

James

Postlethwait

Sandler

2015

PED

View full text Add to dashboard Cite

show abstract

“…Silicone oil, after injection in high concentrations in mice, was found in vacuoles in adipose tissue (8,9), lymph nodes (8,9), liver (8,9), kidney ( 8 ) , spleen (8,9), pancreas (8), and ovary (8). Its presence, however, was only implied from the microscopic appearance of vacuoles (8,9).…”

Section: Introductionmentioning

confidence: 99%

Migration and Accumulation of Silicone in the Liver of Women with Silicone Gel‐Filled Breast Implants

Pfleiderer

Garrido

1995

Magnetic Resonance in Med

View full text Add to dashboard Cite

1H NMR localized spectroscopy (STEAM), combined with echocardiography (ECG), respiratory gating, and water and fat suppression, was used to quantify silicone concentrations in the liver of women with silicone gel-filled breast implants. Localized spectroscopy was performed on 15 patients with silicone gel-filled breast prostheses and on eight volunteers with no implants. The 1H spectra in the liver of patients showed silicone resonances from 0.3 to -0.8 ppm, attributable to protons in the methyl groups of silicone. The presence of silicone in the liver could first be detected 3-4 years after breast prostheses implantation. No correlation between silicone concentrations and implantation times was observed. However, our results indicated that silicone concentrations may reflect implant integrity: detectable silicone concentrations in the liver appeared to be higher when the implants were ruptured than when the implants appeared intact. Moreover, new resonances in the range of -2.6 to -4 ppm were observed in most patients after long-term implantation. As these species increase with implantation time, the new resonances may reflect chemically changed silicone (paramagnetically shifted silicon complexes bound to iron) accumulated over time. The sensitivity of 1H NMR localized spectroscopy is sufficient to detect silicon concentrations as low as 0.20 mM. Results from one patient whose implants had been removed 14 months prior to the NMR examination showed no detectable silicone in the liver, indicating that it may have been excreted via bile or degraded to silica and high coordinated silicon complexes. Quantitative 1H localized spectroscopy of the liver in women with silicone gel-filled breast implants may provide valuable information concerning silicone accumulation and degradation in vivo, as well as about the kinetics of its elimination from the body after implant removal.

show abstract

“…It was demonstrated previously [3,13] that the RES is partially infil trated by aggregates of silicone fluid (siliconomata). In our experiment histological examination of the mesenteric lymph nodes, mesentery and liver revealed, in the two groups injected /.…”

Section: Discussionmentioning

confidence: 91%

“…Several experimental studies deal ing with the systemic effect of subcutaneous or intraperitoneal injection of silicone fluid revealed the accumulation of it in wandering macrophages, lymph nodes and the entire reticuloendothelial system (RES) [3,13]. The foamy phagocytes filled with silicone fluid tend to aggregate in granulo ma-like structures in the RES.…”

mentioning

confidence: 99%

Prolonged Allograft Survival by Partial Block of the Reticuloendothelial System with Silicone Fluid

Ben-Hur

1970

Eur Surg Res

View full text Add to dashboard Cite

Visceral Response to Subcutaneous and Intraperitoneal Injections of Silicone in Mice

Cited by 107 publications

References 0 publications

Solid noninfectious growing masses over cerebrospinal fluid shunts: report of 3 cases

Solid noninfectious growing masses over cerebrospinal fluid shunts: report of 3 cases

Migration and Accumulation of Silicone in the Liver of Women with Silicone Gel‐Filled Breast Implants

Prolonged Allograft Survival by Partial Block of the Reticuloendothelial System with Silicone Fluid

Contact Info

Product

Resources

About