Visceral pleural involvement in nonsmall cell lung cancer: prognostic significance

Osaki, Toshihiro; Nagashima, Akira; Yoshimatsu, Takashi; Yamada, Sosuke; Yasumoto, Kosei

doi:10.1016/j.athoracsur.2003.10.058

Cited by 61 publications

(55 citation statements)

References 11 publications

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“…Osaki et al (2) and Shimizu et al (3,4) reported approximately 10-30% worse 5-year survival in tumors with VPI compared to those without VPI (45.6-49.8% in VPI group and 60.7-79.0% in non-VPI group). In the 7 th edition of TNM classification for NSCLC, VPI increases the T staging factor of a tumor from T1 to T2 and upstages the tumor, even when ≤3 cm, from stage IA to stage IB (5).…”

Section: Introductionmentioning

confidence: 94%

Visceral pleural invasion in lung adenocarcinoma ≤3 cm with ground-glass opacity: a clinical, pathological and radiological study

Zhao¹,

Xie²,

Zhang³

et al. 2016

J. Thorac. Dis.

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Background: Visceral pleural invasion (VPI) had been demonstrated as an aggressive sign in non-small cell lung cancers (NSCLC). However, its incidence and clinical relevance in early lung cancer showing ground glass nodules (GGNs) has not been clarified. Results: Out of 156 enrolled patients, 38 had pathologically confirmed VPI. The incidence of VPI was 41.5% (27/65) if the tumor diameter was larger than 2.0 cm and 14.3% (13/91) if diameter was smaller than 2.0 cm (P<0.001). Further, the incidence was 17.4% (12/69) in pure GGNs and 32.2% (28/87) in part-solid GGNs (P=0.040). The tumor size and the nodule nodule-pleural relationship were significant predictors of positive VPI. In cases with pleural indentation, attachment, and closeness, the incidence was 38.1%, 25.5%, and 5.3%, respectively (P=0.001). All cases were PL0 and PL1, with no PL2 cases observed.Conclusions: Although VPI was visible in both pure/mix GGNs, it was more common in larger (>2 cm) GGNs. The radiographic findings of nodule abutment or a pleural tag did not reliably predict or exclude VPI. In patients with GGNs, a low rate of PL2 invasion may be observed.

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Section: Introductionmentioning

confidence: 94%

Visceral pleural invasion in lung adenocarcinoma ≤3 cm with ground-glass opacity: a clinical, pathological and radiological study

Zhao¹,

Xie²,

Zhang³

et al. 2016

J. Thorac. Dis.

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“…2 cm and Յ 3 cm [2-3 cm]). In addition, visceral pleural invasion (VPI) is known to be a factor of poor prognosis, [11][12][13][14][15][16][17] and the presence of VPI upstages the T stage from T1 to T2. [18][19][20] Because most studies focused on overall survival (OS) and the natural history of early stage tumors is better refl ected by the cumulative incidence of recurrence (CIR), the clinical signifi cance of VPI in these small, early stage tumors is poorly defi ned.…”

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confidence: 99%

Visceral Pleural Invasion Does Not Affect Recurrence or Overall Survival Among Patients With Lung Adenocarcinoma ≤ 2 cm

Nitadori

Colovos

Kadota

et al. 2013

Chest

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Lung cancer is the second most common cancer and is the primary cause of cancer-related death in both men and women in the United States. 1 Currently, 80% of patients with lung cancer are given a diagnosis of primary non-small cell lung cancer (NSCLC). The most common form of NSCLC is adenocarcinoma (ADC). 2,3 Advances in imaging technology and recommendations to screen high-risk patients with CT scan have increased the probability of detecting small, early stage lung ADC. 4 The most effective treatment of early stage lung ADC is surgical resection; however, the reported 5-year survival rates for patients with stage I disease range from 60% to 90% after complete resection. [5][6][7][8][9] Prognosis for patients with lung ADC is best characterized by the seventh edition of the Union for International Cancer Control/American Joint Committee on Cancer TNM staging classification. 10 For T stage, tumor size has been found to have prognostic signifi cance, and its analysis has led to recommendations to subclassify small tumors ( Յ 3 cm) into two subsets: T1a ( Յ 2 cm) and T1b ( . 2 cm and Յ 3 cm [2-3 cm]). In addition, visceral pleural invasion (VPI) is known to be a factor of poor prognosis, [11][12][13][14][15][16][17] and the presence of VPI upstages the T stage from T1 to T2. [18][19][20] Because most studies focused on overall survival (OS) and the natural history of early stage tumors is better refl ected by the cumulative incidence of recurrence (CIR), the clinical signifi cance of VPI in these small, early stage tumors is poorly defi ned. The goal of the present study was to reevaluate the

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“…We further analyzed the characteristic features of tumor cells among patients who underwent anatomic resection, in order to identify its effect on disease-free and overall survival rates. Previous studies had reported that several pathological factors were related to survival rate; these factors include visceral pleural invasion, [19][20][21][22] vascular invasion, [23] perineural invasion, [24][25][26] histologic grade, [27] and nuclear atypia. [28] Our multivariate analysis indicated that only perineural invasion had a significant effect on disease-free and overall survival rates among N2 NSCLC patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in resectable pathological N2 disease of non-small cell lung cancer

Hsieh

Liu

et al. 2015

Biomed J

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Visceral pleural involvement in nonsmall cell lung cancer: prognostic significance

Cited by 61 publications

References 11 publications

Visceral pleural invasion in lung adenocarcinoma ≤3 cm with ground-glass opacity: a clinical, pathological and radiological study

Visceral pleural invasion in lung adenocarcinoma ≤3 cm with ground-glass opacity: a clinical, pathological and radiological study

Visceral Pleural Invasion Does Not Affect Recurrence or Overall Survival Among Patients With Lung Adenocarcinoma ≤ 2 cm

Prognostic factors in resectable pathological N2 disease of non-small cell lung cancer

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