Visceral Pain Produced by Balloon Distension of the Jejunum

Bentley, F. H.; Smithwick, ReginaldH.

doi:10.1016/s0140-6736(00)91372-2

Cited by 41 publications

(12 citation statements)

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“…52 The peripheral neurons of this viscerosensory system are located in the posterior root ganglia with a visceral projection along sympathetic-splanchnic pathways and a central projection into the spinal cord. [53][54][55] Different probe stimuli including mechanical, thermal, chemical and electrical stimulation have been used to investigate gut sensitivity, 56 It is noteworthy that the sensations induced by different types of experimental stimuli in healthy subjects are similar to the symptoms reported by patients with functional gut disorders in the clinic including abdominal fullness/bloating, cramps, stinging sensation and nausea. 56 However, recent data indicate that different gut stimuli, specifically gastric balloon distension and intragastric nutrient infusion, induce differential brain responses.…”

Section: Stimulus-related Perceptionmentioning

confidence: 99%

Biogastronomy: Factors that determine the biological response to meal ingestion

Pribić

Azpiroz

2018

Neurogastroenterology Motil

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The aim of this narrative review is to provide a comprehensive overview and to define the framework to investigate the factors that determine the postprandial experience. Based on a series of proof-of-concept studies and related information, we propose that the biological responses to a meal depend on the characteristics of the meal, primarily its palatability and composition, and the responsiveness of the guest, which may be influenced by multiple previous and concurrent conditioning factors. This information provides the scientific backbone to the development of personalized gastronomy.

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Section: Stimulus-related Perceptionmentioning

confidence: 99%

Biogastronomy: Factors that determine the biological response to meal ingestion

Pribić

Azpiroz

2018

Neurogastroenterology Motil

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“…However, under some circumstances, gut stimuli may activate afferents with cortical projection and induce conscious perception of abdominal sensations. The peripheral neurone of this viscerosensory system follows sympathetic–splanchnic pathways up to the spinal cord 1–5 …”

Section: Introductionmentioning

confidence: 99%

“…The peripheral neurone of this viscerosensory system follows sympathetic-splanchnic pathways up to the spinal cord. [1][2][3][4][5] Abdominal symptoms in the absence of organic cause usually reflect a digestive dysfunction. In some cases, the alteration can be clearly demonstrated, and specific syndromes have been identified.…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal perception: pathophysiological implications

Azpiroz

2002

Neurogastroenterology Motil

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Physiological gut stimuli during the digestive process are not normally perceived. However, gut stimuli activate a variety of afferent pathways and in some circumstances may induce conscious sensations. Experimental evidence gathered during the past decade suggests that patients with functional gut disorders and unexplained abdominal symptoms may have a sensory dysfunction of the gut, so that physiological stimuli would induce symptoms. Assessment of visceral sensitivity is still poorly developed, but in analogy to somatosensory testing, differential stimulation of visceral afferents may be achieved by a combination of stimulation techniques, which may help to characterize sensory dysfunctions. Visceral afferent input is modulated by a series of mechanisms at different levels of the brain gut axis, and conceivably, a dysfunction of these regulatory mechanisms could cause hyperalgesia. The sensory dysfunction in functional patients seems associated to altered reflex activity, and both mechanisms may interact to produce the symptoms. Evidence of a gut sensory-reflex dysfunction as a common pathophysiological mechanism in different functional gastrointestinal disorders, would suggest that they are different forms of the same process, and that the clinical manifestations depend on the specific pathways affected.

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“…This mechanism explains the classical shoulder-tip pain of diaphragmatic irritation. Bentley and Smithwick (1940) investigating the effect of sympathectomy on hypertensives found that the visceral pain caused by distending a balloon in the jejunum before sympathectomy was abolished on the side of the sympathectomy. Bingham, Inglefinger and Smithwick (1950) found the pain to be reduced but more widespread on the side of the splanchnicectomy, the pathways of which did not regenerate.…”

Section: Discussionmentioning

confidence: 99%