Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping

Kazui, M; Andreoni, Kenneth A.; Williams, G. M.; Perler, Bruce A.; Bulkley, Gregory B.; Beattie, Charles; Donham, Robert T.; Sehnert, Shelley S.; Burdick, James F.; Risby, Terence H.

doi:10.1016/s0741-5214(94)70074-5

Cited by 39 publications

(17 citation statements)

References 11 publications

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“…15,23 Cross-clamping above the renal arteries or celiac artery poses technical challenges, including high retroperitoneal access and the performance of renal bypass, which often translate to increased blood loss and operative duration, and greater rates of renal insufficiency, bowel ischemia, and perioperative mortality. 15,[23][24][25][26][27][28] Myers et al 29 demonstrated that clamping above the renal arteries results in decreased creatinine clearance, while more proximal clamping above the superior mesenteric artery induces mesenteric ischemia/reperfusion injury and further deterioration of renal function. Kidney dysfunction has been shown to be an independent risk factor for long-term mortality.…”

Section: Discussionmentioning

confidence: 99%

Predictors of decreased short- and long-term survival following open abdominal aortic aneurysm repair

Nathan

Brinster

Jackson

et al. 2011

Journal of Vascular Surgery

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Open AAA repair can be done with low morbidity and mortality in the era of endovascular aneurysm repair. Careful consideration should be given to preoperative optimization and perioperative care in patients with chronic obstructive pulmonary disease, chronic renal insufficiency, and cerebrovascular disease. Postoperative decrease in renal function and pulmonary complication portend decreased 5-year survival; strategies to ameliorate these factors should be sought.

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Section: Discussionmentioning

confidence: 99%

Predictors of decreased short- and long-term survival following open abdominal aortic aneurysm repair

Nathan

Brinster

Jackson

et al. 2011

Journal of Vascular Surgery

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“…Methylated alkanes have also been proposed as markers of oxidative stress [1, 101]. Increased concentrations of exhaled n-alkanes have been observed following reperfusion of cardiopulmonary bypass [102] and in subjects with abdominal ischemia [103], ischemic liver [104], myocardial infarction [105], and ischemic heart disease [106]. Sepsis, or systemic inflammatory response syndrome, patients exhale significantly more pentane compared to that exhaled by healthy subjects [70].…”

Section: Underlying Principle In Exhaled Breath Analysismentioning

confidence: 99%

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

2016

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Analysis of volatile organic compounds (VOCs) emanating from human exhaled breath can provide deep insight into the status of various biochemical processes in the human body. VOCs can serve as potential biomarkers of physiological and pathophysiological conditions related to several diseases. Breath VOC analysis, a noninvasive and quick biomonitoring approach, also has potential for the early detection and progress monitoring of several diseases. This paper gives an overview of the major VOCs present in human exhaled breath, possible biochemical pathways of breath VOC generation, diagnostic importance of their analysis, and analytical techniques used in the breath test. Breath analysis relating to diabetes mellitus and its characteristic breath biomarkers is focused on. Finally, some challenges and limitations of the breath test are discussed.

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“…Exhaled breath, which may change its chemical signature depending on the physiological or pathophysiological state of disease [12][13][14][15][16][17][18][19][20][21][22][23][24], is considered as one of the most fascinating body fluids/sources. Sampling of breath is non-invasive and can be used for screening, at an intensive care unit (ICU) [25,26], during surgery [27][28][29], or monitoring pre-and post-surgery [30]. Volatile compounds that do not appear normally in exhaled breath can be used for detection of bacterial or fungal infection in the lungs [31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the exhalation kinetics of volatile cancer biomarkers based on their physicochemical properties

et al. 2014

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The current review provides an assessment of the exhalation kinetics of volatile organic compounds (VOCs) that have been linked with cancer. Towards this end, we evaluate various physicochemical properties, such as 'breath:air' and 'blood:fat' partition coefficients, of 112 VOCs that have been suggested over the past decade as potential markers of cancer. With these data, we show that the cancer VOC concentrations in the blood and in the fat span over 12 and 8 orders of magnitude, respectively, in order to provide a specific counterpart concentration in the exhaled breath (e.g., 1 ppb). This finding suggests that these 112 different compounds have different storage compartments in the body and that their exhalation kinetics depends on one or a combination of the following factors: (i) the VOC concentrations in different parts of the body; (ii) the VOC synthesis and metabolism rates; (iii) the partition coefficients between tissue(s), blood and air; and (iv) the VOCs' diffusion constants. Based on this analysis, we discuss how this knowledge allows modeling and simulating the behavior of a specific VOC under different sampling protocols (with and without exertion of effort). We end this review by a brief discussion on the potential role of these scenarios in screening and therapeutic monitoring of cancer.

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Visceral lipid peroxidation occurs at reperfusion after supraceliac aortic cross-clamping

Cited by 39 publications

References 11 publications

Predictors of decreased short- and long-term survival following open abdominal aortic aneurysm repair

Predictors of decreased short- and long-term survival following open abdominal aortic aneurysm repair

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

Assessment of the exhalation kinetics of volatile cancer biomarkers based on their physicochemical properties

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