Visceral leishmaniasis‐associated nephropathy in hospitalised Brazilian patients: new insights based on kidney injury biomarkers

Meneses, Gdayllon Cavalcante; Daher, Elizabeth De Francesco; Silva, Geraldo B. da; Bezerra, Gabriela Freire; Rocha, Thaiany Pereira da; Azevedo, Isabella Evelyn Prado de; Libório, Alexandre Braga; Martins, Alice Maria Costa

doi:10.1111/tmi.13127

Cited by 19 publications

(41 citation statements)

References 37 publications

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“…and Plasmodium spp. In patients with visceral leishmaniasis (VL), Meneses et al [ 49 ] examined urine KIM-1 (uKIM-1). The mean uKIM-1 level was above 3 times higher in patients with VL and acute kidney injury (AKI group) compared to healthy patients, above 2 times higher in patients with VL and without acute kidney injury (non-AKI group) compared to healthy individuals, and almost 1.5 times higher in AKI group compared to the non-AKI group.…”

Section: Discussionmentioning

confidence: 99%

“…The authors reported a higher expression of KIM-1 in the AKI group compared to the non-AKI and control group of patients. Meneses et al [ 49 ], van Wolfswinkel et al [ 50 ], and Punsawad and Viriyavejakul [ 51 ] suggested that KIM-1 is not a promising biomarker for early detection of nephropathy in visceral leishmaniasis and malaria. Contrary to the aforementioned studies, we suggest that KIM-1 can be considered for the early detection of renal acanthamoebiasis.…”

Section: Discussionmentioning

confidence: 99%

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Potential Biomarkers in Diagnosis of Renal Acanthamoebiasis

Kot

Kupnicka

Witulska

et al. 2021

IJMS

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Recent studies indicate that Acanthamoeba spp. may play a significant role in kidney dysfunction. The aim of the study was to examine the levels of kidney injury molecule 1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemotactic protein 1 (MCP-1), as well as an activity of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9, respectively) in the kidneys of immunocompetent and immunosuppressed mice infected with Acanthamoeba spp. The levels of KIM-1, NGAL, and MCP-1 were analyzed by enzyme-linked immunosorbent assay (ELISA), and the activity of MMPs was determined by gelatin zymography. The elevated KIM-1 level was found in the kidneys of immunocompetent mice at the beginning of Acanthamoeba spp. infection. In the immunosuppressed mice, the KIM-1 level was statistically different. The statistically decreased NGAL level was found in the kidneys of immunocompetent mice compared to the uninfected mice. In the immunocompromised mice, we found statistically significant differences in MCP-1 levels between the uninfected and infected groups. There was an increase in the expression of both MMP-2 and MMP-9 in the kidneys of immunocompetent and immunosuppressed mice infected with Acanthamoeba spp. compared to the uninfected mice. The results indicate that KIM-1, NGAL, MCP-1, MMP-2, MMP-9, and MMP-9/NGAL might be promising biomarkers of renal acanthamoebiasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Potential Biomarkers in Diagnosis of Renal Acanthamoebiasis

Kot

Kupnicka

Witulska

et al. 2021

IJMS

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“…However, understandings of kidney involvement are still limited. Clinical observation revealed acute kidney injury [ 3 ] and renal tubular dysfunction [ 4 ]. Pathologically, both glomerulonephritis [ 5 ] and interstitial nephritis [ 6 ] have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…A case series of visceral Leishmaniasis reported clinical presentations of proximal tubular damage with alteration in low-molecule protein, glucose, and uric acid reabsorption [ 4 ]. Another leishmaniasis case series reported elevated kidney injury molecule-1, a proximal tubule injury biomarker [ 3 ]. The apical exposure to protein overload in proximal tubular cells might induce a proinflammatory phenotype, leading to injury [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Continuous hypergammaglobulinemia and proteinuria after the recovery of the visceral Leishmaniasis: a case report

et al. 2021

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Background Kidney involvement of visceral Leishmaniasis is previously reported, but knowledge is limited. Hypergammaglobulinemia is common in visceral leishmaniasis patients. Whether hypergammaglobulinemia after leishmaniasis depletion can cause kidney injury is not well reported yet. Case presentation We reported a patient who recovered from visceral Leishmaniasis but showed persistent hypergammaglobulinemia and elevated urinary protein. Kidney biopsy showed glomerular hypertrophy with mild segmental mesangial proliferation without tubulointerstitial involvement in light microscopy. No immune complex deposit was found in the mesangial area by neither immunofluorescent staining nor electronic microscope. Increased lysosomes were observed in proximal tubules by electronic microscope. Valsartan was administered to decrease urinary protein, and no immune-suppressive therapy was added. The urinary protein and serum IgG level gradually dropped, and serum creatinine level remained stable during three- month follow up. Conclusions Hypergammaglobulinemia is unlikely to cause renal structural or functional damage in the short term. Angiotensin blockade significantly reduced urine protein, with a minor effect on IgG elimination.

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“…In 2014, in a prospective study, we showed high levels of urinary MCP-1 and urinary oxidative stress in patients with visceral leishmaniasis who had normal serum creatinine, suggesting the presence of glomerular inflammation and incipient renal damage 22 . Another biomarker that seems to be reliable for the early detection of subclinical kidney injury in tropical diseases is NGAL, which had a good accuracy in a recent study from our group 68 .…”

Section: Use Of New Biomarkers In Tropical Diseasesmentioning

confidence: 94%

Novel kidney injury biomarkers in tropical infections: a review of the literature

Meneses

Silva

Tôrres

et al. 2020

Rev. Inst. Med. trop. S. Paulo

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Visceral leishmaniasis‐associated nephropathy in hospitalised Brazilian patients: new insights based on kidney injury biomarkers

Abstract: Visceral leishmaniasis-associated nephropathy showed important proximal tubular injury and glomerular inflammation. Serum NGAL showed an early association with VL-associated nephropathy and may be used to improve clinical management strategies and decrease morbimortality in VL patients.

Cited by 19 publications

References 37 publications

Potential Biomarkers in Diagnosis of Renal Acanthamoebiasis

Potential Biomarkers in Diagnosis of Renal Acanthamoebiasis

Continuous hypergammaglobulinemia and proteinuria after the recovery of the visceral Leishmaniasis: a case report

Novel kidney injury biomarkers in tropical infections: a review of the literature

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