Visceral Ischemia-Reperfusion Injury Promotes Tumor Necrosis Factor (Tnf) and Interleukin-1 (Il-1) Dependent Organ Injury in the Mouse

Welborn, M. Burress; Douglas, Wade G.; Abouhamze, Zaher; Auffenburg, Troy; Abouhamze, Amer; Baumhofer, Julie; Seeger, James M.; Pruitt, Jeffrey H.; Edwards, Paul D.; Chizzonite, R; Martin, David; Moldawer, Lyle L.; Harward, Timothy R.S.

doi:10.1097/00024382-199609010-00003

Cited by 50 publications

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“…The reaction mixture consisted of the supernatant, 1.6 mM tetramethyl benzidine (Sigma Chemical Co.), 80 mM sodium phosphate buffer (pH 5.4), and 0.3 mM hydrogen peroxide. This mixture was incubated at 37°C for 110 s, and the absorbance was measured at 450 nm [19].…”

Section: Mpo Estimationmentioning

confidence: 99%

Leishmanial lipid suppresses the bacterial endotoxin-induced inflammatory response with attenuation of tissue injury in sepsis

Chatterjee

Das

Bose

et al. 2014

Journal of Leukocyte Biology

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The use of live, attenuated, or genetically modified microbes or their cellular component(s) or metabolites has begun to emerge as a potential new approach in medicinal research to deliver biologically active entities. Thus, advancing our knowledge of such microbe-mediated therapy may suggest new avenues for therapeutic intervention in many diseases. We had earlier reported that the total lipid of attenuated Leishmania donovani suppressed the inflammatory responses in rheumatoid arthritis patients. Our present study reveals that the pLLD, isolated from pathogenic L. donovani, decreases the inflammatory level of bacterial endotoxin in stimulated mouse macrophages, as also in the in vivo murine system. It exerts the activity by reducing the level of different mediators, such as cytokine-chemokine(s). It also suppresses the expression of the ubiquitous transcription factor NF-κBp65 in stimulated macrophage cells, improves the endotoxin-associated liver damage, reduces the vascular permeability factors, such as VEGF, and suppresses the expression of cell adhesion molecules, including ICAM-1, VCAM-1, PECAM-1, P-selectin, and E-selectin, in liver of septic mice. These findings indicate that pLLD may prove to be a potential anti-inflammatory agent and protect from endotoxin-induced sepsis in hepatic impairment.

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Section: Mpo Estimationmentioning

confidence: 99%

Leishmanial lipid suppresses the bacterial endotoxin-induced inflammatory response with attenuation of tissue injury in sepsis

Chatterjee

Das

Bose

et al. 2014

Journal of Leukocyte Biology

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“…56 TNF-a has also been implicated in remote organ injury. 57,58 Inhibition of TNF-a in animal models can reduce injury to local and remote organs following ischaemia and reperfusion. 59,60 Immunotherapy has been used to treat reperfusion injury in many animal models.…”

Section: Acute Pancreatitismentioning

confidence: 99%

Tumour Necrosis Factor: Implications for Surgical Patients

Khalil

Hall

Aziz

et al. 2006

ANZ Journal of Surgery

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Tumour necrosis factor alpha (TNF-alpha) is an inflammatory cytokine primarily produced by macrophages. It is a unique protein with contradictive properties; it has the ability to induce cellular death by apoptosis and oncosis, but can also induce cellular regeneration and growth. Genetic polymorphisms in TNFA have been associated with poor outcome in some surgical patients and this may provide a useful tool to screen for high-risk patients. Manipulating TNF-alpha levels in vivo may influence the progression of several pathological conditions. TNF-alpha has anti-cancer properties and has been used to treat cancer patients. Treatment with anti-TNF-alpha drugs and antibodies has been successful in rheumatoid arthritis and other autoimmune diseases, but disappointing in the management of patients with sepsis. This review article focuses on the biological activities, genetic polymorphism of TNFA and the role of TNF-alpha and anti-TNF-alpha treatments, based on animal experiments and clinical trials.

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Risk Factors for MOF and Pattern of Organ Failure Following Severe Trauma

Offner¹,

Moore²

2000

Multiple Organ Failure

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Visceral Ischemia-Reperfusion Injury Promotes Tumor Necrosis Factor (Tnf) and Interleukin-1 (Il-1) Dependent Organ Injury in the Mouse

Cited by 50 publications

References 0 publications

Leishmanial lipid suppresses the bacterial endotoxin-induced inflammatory response with attenuation of tissue injury in sepsis

Leishmanial lipid suppresses the bacterial endotoxin-induced inflammatory response with attenuation of tissue injury in sepsis

Tumour Necrosis Factor: Implications for Surgical Patients

Risk Factors for MOF and Pattern of Organ Failure Following Severe Trauma

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